<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04183

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMADNCSLKELLQESTEDLEATIKMIVAFVLDRDRSCGSLTSLCESFRKKHAELAKLLAKVPAHQEREREIRRLEAEVEARDRILGDLQNQLMAAEKLVTKMVFQADKKVKEMRQSEANRVNSETIIRFANQISRTYAVAAPLGWQLGDTSRPYPTEAELRLSALAAPRVIVQAAPPALSLLRQPAASTSGMLRSGRGASPMTSYSAAMQQQQKSWSPRGTFVQQSSSSPRGRSAGGRGSIISPRIGAAPGAGLLQRRPSMTGSSPHLSSPSSSYQGPIRGGLPPPISNVEQMSSDSSSSSSSDEGSPS
Length308
PositionMiddle
OrganismBrugia malayi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.04
Grand average of hydropathy-0.473
Instability index67.04
Isoelectric point9.70
Molecular weight33179.17
Publications
PubMed=17885136

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04183
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     149.01|      25|      40|     176|     200|       1
---------------------------------------------------------------------------
  176-  200 (43.51/18.50)	PALSLL.RQPAASTSGMLRSGRGA..SP
  217-  243 (38.25/15.46)	PRGTFV.QQSSSSPRGRSAGGRGSiiSP
  249-  270 (31.77/11.71)	PGAGLLqRRP..SMTG..SSPHLS..SP
  285-  307 (35.48/13.86)	P.ISNV.EQMSSDSSSSSSSDEG...SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.54|      37|      39|      55|      91|       2
---------------------------------------------------------------------------
   19-   43 (29.43/15.02)	............E.ATIKMIVAFVLDRDRSCGSLTSLC
   55-   91 (58.89/35.93)	KLLAKVPAHQERE.REIRRLEAEVEARDRILGDLQNQL
   96-  132 (49.22/29.06)	KLVTKMVFQADKKvKEMRQSEANRVNSETII.RFANQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04183 with Med4 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RQPAASTSGMLRSGRGASPMTSYSAAMQQQQKSWSPRGTFVQQSSSSPRGRSAGGRGSIISPRIGAAPGAGLLQRRPSMTGSSPHLSSPSSSYQGPIRGGLPPPISNVEQMSSDSSSSSSSDEGSPS
182
308










Molecular Recognition Features






MoRF SequenceStartStop




1) QGPIRGGLPPPISNV
275
289