<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04182

Description "BMA-DPY-22, isoform a"
SequenceMKSLNVISWHYQTPERRALKRNRLGPPDVYPQDVKQEEDNLGADRLKKGYQVAVTSYEHESIVYNVKMPRLDRLDDTMLRGAQLVMQIMAKKMELNANLDKERRRAGSVITKDSTGSGGNGVGGGPQIYFQQFSHNAEKAKKSKERNDWFTDLAHGKPLAVLARKPPFFRKKEDALEYLCDYKVPVNRALWFLKLIAVSGQGCNSNVNKQKKSTADQLASEFASLFTKYIKLMLNQMSDSAKLESNIVYTDRWPHFVYICKHAYEDGMVEKQEFLMDLLDIFNDRFVQPIENRKNDKTLIHPFLHHGSGFASASSTNHSHYVTLLRLFLLFICQYTDQITQNIVLSKRCAFLVCHRLELYRDEAEEREGRSVDCVELFDDMQQCIHQRAIILTLCGMLYAILIDCPAALIWNKYEVSPGRPPTMLHQLCGSPLDHLPCPFESLPLPPGHGTERLQEFIQLRLAEVRRRSRACENKWSLNYAQKKGFAALVLQCLEIVGVLDAARLDQPNCVEKIYAVIFNGPSKESFEHEHAIRVKMLLQWAVTVEREGTHRAILVAQLLAFRINHRKTFKFGSLTLQEILLEFLVTEGPDPENTDKNRFSQEFANLMLLFIELQRAGVFSHDLYMKELIRTGEMLEYIPLMQKIRKRKEDKQKQHQQLSNTVAFPSTFVSQPNETTAALLTGAVTTPPPLVTMPSELPDEHPFLFKDLSVHERLLIHLPIPQSAEYRSECNQRSLLLYGIGAERDAVKLELRRLARELAKLWQKRIVVEFSFNKPLEIRFKKRTTREQVQESMAKFRSCTYYDQLVLCGWCCESFIQMVQDFVDGHSCLLPTAEGLDIILEMCELAQNIAGIMELAEELLPLLVLIERVLLERRVDCVPSNLSAQLGYVLTAYISHNYYYFLYSQNAPNIVQGLYRVIESQLKSSDFCLTGWGRTIAVFVLDAKKQLIETGLCSRKIEAKRELLKRVIPPWKPAHNIGDRNPCGGQRYAYNASTFKELLEEPKRIFSFNEYRRLHAVIDGTDDARYSFVVSALLAAVHGIGNAGGNDNTGIGSGSAAVERLTGDRLVELANICGHVSAQAAQVEKYLDWCGALQALCCSSLQGGTSTFPDLLMEINVEDSTCHYNIATFYMLLAGRSCFSINALVHQLLHTALKSLLNCGIGKVLDADAEAGVCLALLVLANIVCQSDQPIILSPQYTGERISSNICKADRWILTEGHLHDIGDEVCALLVAICMIADYTKHKLRDRCSDDKPIDQRVFRREYIAELSKGVLMAMCEQEWVTQRIYRRCEDGALDCFSSHQLRKNCLGQQLLRMALRRRSEREIVRELTICNGNSKKSLIDKLLNVLNIWNTRATYFDFKLMIREISPEGCTSKHAQQGAIAADALLGEIGKCCRDLFTQSHKSDKKLPPAAVGKAFRLKDITAYWLISPLVHACPRPGNLPASFPAITVQGKFLKEAAAMLDTSSDNNKERIQQSTWLLSQEPFLNLVLTCLNGEEQQRDGLVGSMLKQLQELALKAKDNPLLPYLRIFSLEREGVLLRISLVGGMFDSVCHTSICDTWALTLFQLMLYGVISKERDGYLFDSCYDMLSTLLVWSITDPMNAAAMNTQDPDTKFRFPTYSLIVKKLRKELNERALIPELRSLIQFLPIPKPQFELITCEPYGTLPTSPQKLGKSQSQGQIIQTTVKANRHGLQFAEKVKLSAYDIIQYLNIDSTLLKRPWNWSMLQAVKLDRLPVPVQRYIQRLVHHSHYNEFVRPTICGMDRPPNLDIYLSPPMMDVSETPATLHHVSSSAATSTTTSASSTNVPVSSGGAAMDVGATLGPVVQGRAMSYQSSSTPTCTSIPDGSTPSSTPGAPSTAATAMIFPGQSGPMPALPDLTGRGQNNASPRGARGGRRKAAGLSTRSQGTTRKQRQQRQQTVDQLAVAAAAAAAAAQQQQQQMGSAVGCGGGPPQQPTYPSTWATGPQQTGVPQQFASGPSAPPSGTGQAGTAMGTQTTEDSKMKIHSMILQKRQAQAASSATATQQGVTGGPQPSMQDVNAYQISAGPPQYGGNMIMKVETGANSMQMVDHTQQQQQQRQQQQYAQQQQLIQMQQDVQGGSQYVVHQQQRGGIAYGQSVQQATYDSRFNQQQLQYGQQPQQQQQQQYHPTQQY
Length2153
PositionKinase
OrganismBrugia malayi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.08
Grand average of hydropathy-0.305
Instability index48.62
Isoelectric point8.51
Molecular weight241309.03
Publications
PubMed=17885136

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04182
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     342.77|     110|     131|    1813|    1941|       1
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 1813- 1939 (170.49/121.84)	GAAmdVGATLGPVVQGramSYQSS..STPTCTSIPD..GSTPSSTPGAPSTAATAMIFPGqsGPMPALPDLTGRgQNNASPrGARGG....RRKAAGLSTRSQGTTRKQ................RQQRQQtvdqlavaAAAAAAA...AQQQQ
 1943- 2026 (98.21/45.86)	GSA..VGCGGGPPQQP...TYPSTwaTGPQQTGVPQqfASGPSAPPSGTGQAGTAM.....................................................gtqttedskmkihsmiLQKRQA........QAASSAT...ATQQ.
 2027- 2089 (74.08/29.35)	........................................................GVTG..GPQPSMQDVNAY.QISAGP.PQYGGnmimKVETGANSMQMVDHTQQQ................QQQRQQ...............qqyAQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.74|      38|      39|    1197|    1235|       2
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 1197- 1235 (63.61/50.02)	QYTGERISSNiCKADRWILTEGHLHD.IGDEVCALLVAIC
 1239- 1277 (61.13/42.73)	DYTKHKLRDR.CSDDKPIDQRVFRREyIAELSKGVLMAMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.38|      77|     132|     570|     655|       3
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  570-  655 (116.61/99.25)	FKFGSLTLQEILLEFLvtegPDPENTD.KNRFSQEfaNLMLLFIELQRAGVfshDLYMKELIRTGEML.......EYI...PLMQKIRKRKEDKQKQ
  704-  791 (112.77/72.84)	FLFKDLSVHERLLIHL....PIPQSAEyRSECNQR..SLLLYGIGAERDAV...KLELRRLARELAKLwqkrivvEFSfnkPLEIRFKKRTTREQVQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.61|      25|     132|     991|    1016|       4
---------------------------------------------------------------------------
  991- 1016 (42.04/32.46)	YNASTFKELLeEPKRIFSFNE..YRRLH
 1125- 1151 (42.58/27.85)	YNIATFYMLL.AGRSCFSINAlvHQLLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.68|      23|      29|    2098|    2120|       5
---------------------------------------------------------------------------
 2098- 2120 (40.89/22.36)	QGGSQYVVHQQQRGGIAYGQSVQ
 2130- 2152 (43.79/24.51)	QQQLQYGQQPQQQQQQQYHPTQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.63|      41|    1210|     188|     228|       6
---------------------------------------------------------------------------
  188-  228 (72.31/40.33)	RALWF.LKLI..AVSGQGCNSNVNKQKKSTADQLASEFA....SLFTK
 1354- 1401 (59.32/31.88)	RATYFdFKLMirEISPEGCTSKHAQQGAIAADALLGEIGkccrDLFTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.57|      28|      33|    1530|    1561|       7
---------------------------------------------------------------------------
 1500- 1523 (24.84/12.32)	............QRDG......LVGSMLKQLQEL..ALKakDNP
 1530- 1561 (48.99/42.37)	IFSL........EREGVLlrisLVGGMFDSVCHT..SIC..DTW
 1565- 1596 (29.74/16.36)	LFQLmlygviskERDGYL.........FDS.CYDmlSTL..LVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.27|      10|      29|    1732|    1743|       8
---------------------------------------------------------------------------
  980-  989 (22.67/ 6.61)	DRNPCGGQRY
 1733- 1742 (20.60/ 6.58)	DRLPVPVQRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.79|      59|    1214|     422|     508|      14
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  439-  508 (83.75/91.62)	PFESLPLPPgHGTERLQEFIQLrlaeVRRRSRAceNKWSLNYAQKKGFAAL.VLQCLEIvgvlDAARLDQP
 1662- 1721 (97.05/45.20)	PYGTLPTSP.QKLGKSQSQGQI....IQTTVKA..NRHGLQFAEKVKLSAYdIIQYLNI....DSTLLKRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.95|      16|      35|    1409|    1425|      15
---------------------------------------------------------------------------
 1409- 1425 (22.85/21.96)	LPPAAVGKAFrLKDITA
 1446- 1461 (27.10/19.79)	FPAITVQGKF.LKEAAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04182 with Med12 domain of Kingdom Metazoa
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