<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04179

Description "BMA-DPY-22, isoform b"
SequenceMLHQLCGSPLDHLPCPFESLPLPPGHGTERLQEFIQLRLAEVRRRSRACENKWSLNYAQKKGFAALVLQCLEIVGVLDAARLDQPNCVEKIYAVIFNGPSKESFEHEHAIRVKMLLQWAVTVEREGTHRAILVAQLLAFRINHRKTFKFGSLTLQEILLEFLVTEGPDPENTDKNRFSQEFANLMLLFIELQRAGVFSHDLYMKELIRTGEMLEYIPLMQKIRKRKEDKQKQHQQLSNTVAFPSTFVSQPNETTAALLTGAVTTPPPLVTMPSELPDEHPFLFKDLSVHERLLIHLPIPQSAEYRSECNQRSLLLYGIGAERDAVKLELRRLARELAKLWQKRIVVEFSFNKPLEIRFKKRTTREQVQESMAKFRSCTYYDQLVLCGWCCESFIQMVQDFVDGHSCLLPTAEGLDIILEMCELAQNIAGIMELAEELLPLLVLIERVLLERRVDCVPSNLSAQLGYVLTAYISHNYYYFLYSQNAPNIVQGLYRVIESQLKSSDFCLTGWGRTIAVFVLDAKKQLIETGLCSRKIEAKRELLKRVIPPWKPAHNIGDRNPCGGQRYAYNASTFKELLEEPKRIFSFNEYRRLHAVIDGTDDARYSFVVSALLAAVHGIGNAGGNDNTGIGSGSAAVERLTGDRLVELANICGHVSAQAAQVEKYLDWCGALQALCCSSLQGGTSTFPDLLMEINVEDSTCHYNIATFYMLLAGRSCFSINALVHQLLHTALKSLLNCGIGKVLDADAEAGVCLALLVLANIVCQSDQPIILSPQYTGERISSNICKADRWILTEGHLHDIGDEVCALLVAICMIADYTKHKLRDRCSDDKPIDQRVFRREYIAELSKGVLMAMCEQEWVTQRIYRRCEDGALDCFSSHQLRKNCLGQQLLRMALRRRSEREIVRELTICNGNSKKSLIDKLLNVLNIWNTRATYFDFKLMIREISPEGCTSKHAQQGAIAADALLGEIGKCCRDLFTQSHKSDKKLPPAAVGKAFRLKDITAYWLISPLVHACPRPGNLPASFPAITVQGKFLKEAAAMLDTSSDNNKERIQQSTWLLSQEPFLNLVLTCLNGEEQQRDGLVGSMLKQLQELALKAKDNPLLPYLRIFSLEREGVLLRISLVGGMFDSVCHTSICDTWALTLFQLMLYGVISKERDGYLFDSCYDMLSTLLVWSITDPMNAAAMNTQDPDTKFRFPTYSLIVKKLRKELNERALIPELRSLIQFLPIPKPQFELITCEPYGTLPTSPQKLGKSQSQGQIIQTTVKANRHGLQFAEKVKLSAYDIIQYLNIDSTLLKRPWNWSMLQAVKLDRLPVPVQRYIQRLVHHSHYNEFVRPTICGMDRPPNLDIYLSPPMMDVSETPATLHHVSSSAATSTTTSASSTNVPVSSGGAAMDVGATLGPVVQGRAMSYQSSSTPTCTSIPDGSTPSSTPGAPSTAATAMIFPGQSGPMPALPDLTGRGQNNASPRGARGGRRKAAGLSTRSQGTTRKQRQQRQQTVDQLAVAAAAAAAAAQQQQQQMGSAVGCGGGPPQQPTYPSTWATGPQQTGVPQQFASGPSAPPSGTGQAGTAMGTQTTEDSKMKIHSMILQKRQAQAASSATATQQGVTGGPQPSMQDVNAYQISAGPPQYGGNMIMKVETGANSMQMVDHTQQQQQQRQQQQYAQQQQLIQMQQDVQGGSQYVVHQQQRGGIAYGQSVQQATYDSRFNQQQLQYGQQPQQQQQQQYHPTQQY
Length1730
PositionKinase
OrganismBrugia malayi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.07
Grand average of hydropathy-0.271
Instability index50.68
Isoelectric point8.39
Molecular weight192643.68
Publications
PubMed=17885136

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04179
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     152.35|      34|      39|    1355|    1391|       1
---------------------------------------------------------------------------
 1355- 1385 (36.59/31.34)	....................MDVSetpATLHHV.........S...........SSAATSTTTSASSTNVP
 1386- 1427 (48.39/31.90)	VSSGGA.............aMDVG...ATLGPVvqgramsyqS...........SS..TPTCTSIPDGSTP
 1428- 1451 (37.41/22.56)	SSTPGA...............................................pSTAATAMIFPGQSGPMP
 1560- 1611 (29.97/16.23)	PSGTGQagtamgtqttedskMKIH..................SmilqkrqaqaaSSA.TATQQGVTGGPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     199.26|      46|      49|    1624|    1672|       2
---------------------------------------------------------------------------
 1528- 1595 (38.15/14.49)	GPPQ.QPTYPSTWATGP...QQTGVPQQFASgpsappsgtgqagtamgtqttedskmkihsmilQKRQAQAA...............
 1624- 1672 (88.01/48.61)	GPPQYGGNMIMKVETGAnsmQMVDHTQQQQQ.................................QRQQQQYAQ..QQQLIQ...MQQ
 1676- 1708 (40.21/15.65)	GGSQY.................VVH....QQ.................................QRGGIAYGQsvQQATYDsrfNQQ
 1709- 1729 (32.89/11.55)	.QLQYG....................QQPQQ.................................Q.QQQQYHP..TQQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.25|      38|      40|     774|     812|       3
---------------------------------------------------------------------------
  774-  812 (63.13/52.26)	QYTGERISSNiCKADRWILTEGHLHD.IGDEVCALLVAIC
  816-  854 (62.12/46.07)	DYTKHKLRDR.CSDDKPIDQRVFRREyIAELSKGVLMAMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.17|      58|     132|     147|     232|       4
---------------------------------------------------------------------------
  147-  213 (82.29/75.46)	FKFGSLTLQEILLEFLvtegPDPENTD.KNRFSQEfaNLMLLFIELQRAGVfshDLYMKELIRTGEML
  281-  339 (90.87/73.62)	FLFKDLSVHERLLIHL....PIPQSAEyRSECNQR..SLLLYGIGAERDAV...KLELRRLARELAKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.83|      25|     132|     568|     593|       5
---------------------------------------------------------------------------
  568-  593 (41.97/28.43)	YNASTFKELLeEPKRIFSFNE..YRRLH
  702-  728 (41.86/23.73)	YNIATFYMLL.AGRSCFSINAlvHQLLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.09|      39|      40|    1078|    1116|       6
---------------------------------------------------------------------------
 1030- 1075 (26.66/13.04)	.....GKFLKEAAAMLDTSSDNnkeriqqstwllsqePFLN.LV.....LTCLNGEE..
 1078- 1116 (63.56/42.00)	RDGLVGSMLKQLQELALKAKDN...............PLLPYLR.....IFSLEREGVL
 1118- 1159 (55.87/35.97)	RISLVGGMFDSVCHTSIC..DT...............WALTLFQlmlygVISKERDGYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.27|      10|      29|    1309|    1320|       7
---------------------------------------------------------------------------
  557-  566 (22.67/ 9.32)	DRNPCGGQRY
 1310- 1319 (20.60/ 9.28)	DRLPVPVQRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.39|      72|     851|      37|     116|       8
---------------------------------------------------------------------------
   37-  116 (109.19/81.49)	LRLAeVRRRS.RACENKWSL.NYAQKKGFAALVLQCLEIVGVlDAARLDQPNCVEKIyavifnGPSKESFEH..EHAIRVKMLL
  890-  965 (108.20/61.92)	LRMA.LRRRSeREIVRELTIcNGNSKKSLIDKLLNVLNIWNT.RATYFDFKLMIREI......SPEGCTSKHaqQGAIAADALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.93|      17|      19|    1479|    1496|      11
---------------------------------------------------------------------------
 1479- 1495 (28.11/10.48)	LSTRSQGTTRKQRQQRQ
 1501- 1517 (22.83/ 7.22)	LAVAAAAAAAAAQQQQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04179 with Med12 domain of Kingdom Metazoa
Unable to open file!