<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04178

Description "BMA-DPY-22, isoform b"
SequenceMQQCIHQRAIILTLCGMLYAILIDCPAALIWNKYEVSPGRPPTMLHQLCGSPLDHLPCPFESLPLPPGHGTERLQEFIQLRLAEVRRRSRACENKWSLNYAQKKGFAALVLQCLEIVGVLDAARLDQPNCVEKIYAVIFNGPSKESFEHEHAIRVKMLLQWAVTVEREGTHRAILVAQLLAFRINHRKTFKFGSLTLQEILLEFLVTEGPDPENTDKNRFSQEFANLMLLFIELQRAGVFSHDLYMKELIRTGEMLEYIPLMQKIRKRKEDKQKQHQQLSNTVAFPSTFVSQPNETTAALLTGAVTTPPPLVTMPSELPDEHPFLFKDLSVHERLLIHLPIPQSAEYRSECNQRSLLLYGIGAERDAVKLELRRLARELAKLWQKRIVVEFSFNKPLEIRFKKRTTREQVQESMAKFRSCTYYDQLVLCGWCCESFIQMVQDFVDGHSCLLPTAEGLDIILEMCELAQNIAGIMELAEELLPLLVLIERVLLERRVDCVPSNLSAQLGYVLTAYISHNYYYFLYSQNAPNIVQGLYRVIESQLKSSDFCLTGWGRTIAVFVLDAKKQLIETGLCSRKIEAKRELLKRVIPPWKPAHNIGDRNPCGGQRYAYNASTFKELLEEPKRIFSFNEYRRLHAVIDGTDDARYSFVVSALLAAVHGIGNAGGNDNTGIGSGSAAVERLTGDRLVELANICGHVSAQAAQVEKYLDWCGALQALCCSSLQGGTSTFPDLLMEINVEDSTCHYNIATFYMLLAGRSCFSINALVHQLLHTALKSLLNCGIGKVLDADAEAGVCLALLVLANIVCQSDQPIILSPQYTGERISSNICKADRWILTEGHLHDIGDEVCALLVAICMIADYTKHKLRDRCSDDKPIDQRVFRREYIAELSKGVLMAMCEQEWVTQRIYRRCEDGALDCFSSHQLRKNCLGQQLLRMALRRRSEREIVRELTICNGNSKKSLIDKLLNVLNIWNTRATYFDFKLMIREISPEGCTSKHAQQGAIAADALLGEIGKCCRDLFTQSHKSDKKLPPAAVGKAFRLKDITAYWLISPLVHACPRPGNLPASFPAITVQGKFLKEAAAMLDTSSDNNKERIQQSTWLLSQEPFLNLVLTCLNGEEQQRDGLVGSMLKQLQELALKAKDNPLLPYLRIFSLEREGVLLRISLVGGMFDSVCHTSICDTWALTLFQLMLYGVISKERDGYLFDSCYDMLSTLLVWSITDPMNAAAMNTQDPDTKFRFPTYSLIVKKLRKELNERALIPELRSLIQFLPIPKPQFELITCEPYGTLPTSPQKLGKSQSQGQIIQTTVKANRHGLQFAEKVKLSAYDIIQYLNIDSTLLKRPWNWSMLQAVKLDRLPVPVQRYIQRLVHHSHYNEFVRPTICGMDRPPNLDIYLSPPMMDVSETPATLHHVSSSAATSTTTSASSTNVPVSSGGAAMDVGATLGPVVQGRAMSYQSSSTPTCTSIPDGSTPSSTPGAPSTAATAMIFPGQSGPMPALPDLTGRGQNNASPRGARGGRRKAAGLSTRSQGTTRKQRQQRQQTVDQLAVAAAAAAAAAQQQQQQMGSAVGCGGGPPQQPTYPSTWATGPQQTGVPQQFASGPSAPPSGTGQAGTAMGTQTTEDSKMKIHSMILQKRQAQAASSATATQQGVTGGPQPSMQDVNAYQISAGPPQYGGNMIMKVETGANSMQMVDHTQQQQQQRQQQQYAQQQQLIQMQQDVQGGSQYVVHQQQRGGIAYGQSVQQATYDSRFNQQQLQYGQQPQQQQQQQYHPTQQY
Length1773
PositionKinase
OrganismBrugia malayi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.07
Grand average of hydropathy-0.254
Instability index50.98
Isoelectric point8.41
Molecular weight197468.45
Publications
PubMed=17885136

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04178
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     152.35|      34|      39|    1398|    1434|       1
---------------------------------------------------------------------------
 1398- 1428 (36.59/27.62)	....................MDVSetpATLHHV.........S...........SSAATSTTTSASSTNVP
 1429- 1470 (48.39/28.11)	VSSGGA.............aMDVG...ATLGPVvqgramsyqS...........SS..TPTCTSIPDGSTP
 1471- 1494 (37.41/19.85)	SSTPGA...............................................pSTAATAMIFPGQSGPMP
 1603- 1654 (29.97/14.25)	PSGTGQagtamgtqttedskMKIH..................SmilqkrqaqaaSSA.TATQQGVTGGPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     199.26|      46|      49|    1667|    1715|       2
---------------------------------------------------------------------------
 1571- 1638 (38.15/15.99)	GPPQ.QPTYPSTWATGP...QQTGVPQQFASgpsappsgtgqagtamgtqttedskmkihsmilQKRQAQAA...............
 1667- 1715 (88.01/53.72)	GPPQYGGNMIMKVETGAnsmQMVDHTQQQQQ.................................QRQQQQYAQ..QQQLIQ...MQQ
 1719- 1751 (40.21/17.27)	GGSQY.................VVH....QQ.................................QRGGIAYGQsvQQATYDsrfNQQ
 1752- 1772 (32.89/12.73)	.QLQYG....................QQPQQ.................................Q.QQQQYHP..TQQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.25|      38|      40|     817|     855|       3
---------------------------------------------------------------------------
  817-  855 (63.13/48.08)	QYTGERISSNiCKADRWILTEGHLHD.IGDEVCALLVAIC
  859-  897 (62.12/42.37)	DYTKHKLRDR.CSDDKPIDQRVFRREyIAELSKGVLMAMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.17|      58|     132|     190|     275|       4
---------------------------------------------------------------------------
  190-  256 (82.29/56.12)	FKFGSLTLQEILLEFLvtegPDPENTD.KNRFSQEfaNLMLLFIELQRAGVfshDLYMKELIRTGEML
  324-  382 (90.87/54.75)	FLFKDLSVHERLLIHL....PIPQSAEyRSECNQR..SLLLYGIGAERDAV...KLELRRLARELAKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.83|      25|     132|     611|     636|       5
---------------------------------------------------------------------------
  611-  636 (41.97/35.81)	YNASTFKELLeEPKRIFSFNE..YRRLH
  745-  771 (41.86/29.90)	YNIATFYMLL.AGRSCFSINAlvHQLLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.09|      39|      40|    1121|    1159|       6
---------------------------------------------------------------------------
 1073- 1118 (26.66/11.55)	.....GKFLKEAAAMLDTSSDNnkeriqqstwllsqePFLN.LV.....LTCLNGEE..
 1121- 1159 (63.56/37.36)	RDGLVGSMLKQLQELALKAKDN...............PLLPYLR.....IFSLEREGVL
 1161- 1202 (55.87/31.98)	RISLVGGMFDSVCHTSIC..DT...............WALTLFQlmlygVISKERDGYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.27|      10|      29|    1352|    1363|       7
---------------------------------------------------------------------------
  600-  609 (22.67/ 8.14)	DRNPCGGQRY
 1353- 1362 (20.60/ 8.11)	DRLPVPVQRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.39|      72|     851|      80|     159|       8
---------------------------------------------------------------------------
   80-  159 (109.19/100.93)	LRLAeVRRRS.RACENKWSL.NYAQKKGFAALVLQCLEIVGVlDAARLDQPNCVEKIyavifnGPSKESFEH..EHAIRVKMLL
  933- 1008 (108.20/76.68)	LRMA.LRRRSeREIVRELTIcNGNSKKSLIDKLLNVLNIWNT.RATYFDFKLMIREI......SPEGCTSKHaqQGAIAADALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.93|      17|      19|    1522|    1539|      10
---------------------------------------------------------------------------
 1522- 1538 (28.11/12.94)	LSTRSQGTTRKQRQQRQ
 1544- 1560 (22.83/ 8.98)	LAVAAAAAAAAAQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.95|      34|      47|    1229|    1267|      15
---------------------------------------------------------------------------
 1229- 1267 (48.42/45.12)	TQDPDTKFrfPTYSlivKKLRKELNERALIPEL....RSLIQF
 1279- 1316 (56.53/36.57)	TCEPYGTL..PTSP...QKLGKSQSQGQIIQTTvkanRHGLQF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04178 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ETPATLHHVSSSAATSTTTSASSTNVPVSSGGAAMDVGATLGPVVQGRAMSYQSSSTPTCTSIPDGSTPSSTPGAPSTAATAMIFPGQSGPMPALPDLTGRGQNNASPRGARGGRRKAAGLSTRSQGTTRKQRQQRQQTVDQLAVAAAAAAAAAQQQQQQMGSAVGCGGGPPQQPTYPSTWATGPQQTGVPQQFASGPSAPPSGTGQAGTAMGTQTTEDSKMKIHSMILQKRQAQAASSATATQQGVTGGPQPSMQDVNAYQISAGPPQYGGNMIMKVETGANSMQMVDHTQQQQQQRQQQQYAQQQQLI
1402
1711










Molecular Recognition Features






MoRF SequenceStartStop




1) QYHPTQQY
1766
1773