<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04169

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNVNIEGSVRRPGLSEARNGVPNAFDNADKAGQLSGMNGSVYVNGTSSGITASNQHPRTPADKAVEIVPSSPFKLPHITQGFFPFGTLVNRSVQECWNELSELITELATIQVPASGGSISTNGKPAGNQSSENVHKKLRLLDFAHAKRAEFIKLLVLSQWSRQAADVSRLIDIQGFIRTRHQSYDAALQYVGEVKRDLVRAQVANPDLKTAVEVLSKGRVASLPDLGYKPPTPLTARATLKKLLKLNRIISVRLALHDSVPPPLRNYRVHDGRVTFTISGEFELDLSVAEETKTSQFFFVDIRFLFSPSSPIPKGRIFNELDGKINDLLRDDGLTGCFQFLHGLVLTNKINILFKQAVDLSRGLWADALRIELLHRTLVVQYWPQRSGPKSWLEIGVKSGHRGGSSSDPNPGISHLGFRWMRDGQQVSSDAIRFNPGDLSMELILRSVIALHTSHLLSTAFTTLKKHVLFSNHTLSLQAQLSPTEPGDCRLDVQLTASRSLRVSIEPMSGSITMCGTPHVLERLDGDRGLYKSSIEEILSRVARLRCITAVDEIDSGTKALGLEPVNQRVLGLDPRKLFPPGVMRTAFFTHRLWNRHWIAAATSSMDGDRWWLVQLRPTEATKMGSFYSIGDHSVGAPQAHVVSETLVPPQRRLNYTTCAELVHGLTGILAIHANARYLADLPAMNFWPTFKELKLETDLTVPDLLFNYSSSTLPPAFRVTLPFGAKKQSQFKEMIRLVFHGIDSQTRSVIMMAHGSLKTRIKSLVPLVSNTDPSLIIEDRGSGFALRLLVPAGHSVVACLFELLQRLECVLSILQSLIRKGMEPRSLSLSRIDFAYGPENKFSAFFDMNAKGPSLSDYVDVADAISKTTPLFELKLGIKFESSSPHRRIQEPLTVALNQRFTEAGVESTLQLLATTLPLLRSLDQITAQSNQTDLSIVQVIARKPTVYLIHYPRLRSRFHLSAVMHQDHLVWMLRDSNGMDQSGRGQVDAFIQEKLYQSKGDGWNGLGDGAVASISKVGNLILEMHECLNAPHLQLDREVEVKPEQIPKQLHIKGSTSAALQTLGNTDVITID
Length1080
PositionTail
OrganismPenicillium camemberti FM 013
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.144
Instability index46.06
Isoelectric point9.14
Molecular weight119493.72
Publications
PubMed=24407037

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04169
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.80|      96|     236|      75|     222|       1
---------------------------------------------------------------------------
   75-  214 (136.70/192.94)	PSSPfkLPHiTQGFFPFGTLVNRSVQE.....CWNELSELItelatiqvpasggsistngkpagnqssenvhkklrlldFAHAKRAEFI.KLLVLSQWSRQAADVSRL.IDIQGFIRTRHQS.YDAALQYVG........EVKRDLVRAqvaNP.DL
  314-  445 (133.10/89.05)	PSSP..IPK.GRIFNELDGKINDLLRDdgltgCFQFLHGLV...................ltnkinilfkqavdlsrglWADALRIELLhRTLVVQYWPQRSGPKSWLeIGVKSGHRGGSSSdPNPGISHLGfrwmrdgqQVSSDAIRF...NPgDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.31|      31|     235|     241|     271|       2
---------------------------------------------------------------------------
  241-  271 (52.82/32.36)	TARATLKK.LLKLNRIISVRLALHDSVPPPLR
  465-  496 (49.49/29.85)	TAFTTLKKhVLFSNHTLSLQAQLSPTEPGDCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.93|      36|     964|      19|      59|       9
---------------------------------------------------------------------------
   19-   59 (48.66/45.45)	GLSEARNGVPNAFdNADKAGQLSGmNGsvyVNGTSSGITAS
  986- 1021 (66.27/40.81)	GMDQSGRGQVDAF.IQEKLYQSKG.DG...WNGLGDGAVAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04169 with Med14 domain of Kingdom Fungi
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