Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MADESQQRAVNTAFAPPPPLWKHFTRENIDKVEQIKAEASKKEDGRPNKNKQWSAAELRALELPSELRYLVPPDIPEGQYSVFGELQTMSTTLPSLQEQGIEQLYPEPPAAGTEQNSQPSPPLNHAYYLLKISKSLLLNFLEFTGILSVSPEQFESKVEDLRNLFINAHHLLNLYRPHQARESLIMMMEEQLNHSREEMRQMDKVKAEVESVLEQLQAEGSRVSATGPEDDTDQAKALKEKADEHSRLIWDLLDKEN |
Length | 257 |
Position | Middle |
Organism | Penicillium camemberti FM 013 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.745 |
Instability index | 56.63 |
Isoelectric point | 4.96 |
Molecular weight | 29340.63 |
Publications | PubMed=24407037 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060 ECO:0000256 ARBA:ARBA00003669 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04168 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 94.92| 30| 179| 26| 62| 1 --------------------------------------------------------------------------- 33- 62 (50.23/39.30) EQIKAEASK.KEDGRPNKNKQWSAAELRALE 214- 244 (44.69/21.44) EQLQAEGSRvSATGPEDDTDQAKALKEKADE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DQAKALKEKADEHSRLIWDLLDKE 2) PLWKHFTRENIDKVEQIKAEA 3) YYLLK | 233 19 127 | 256 39 131 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab