<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04162

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEEAGITSNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLKPLYVRGSDAESNRIVVGTTTLKVSALGSVSSLDLVKGLSSDNQSQHGTQPAGQPRPHQGQPSPRRQDGYSSSAAIYASFISAVTGSIGLQLIRRHAALPLGSRTLFTAVEKSGYESPHINNDNILSTSCLTTLNIQLTMSGTITVSAQTISQAGITRLCTPHEDISERIDVQPGIDLWLCPNGTIAKLVTANIDSSTVPSPSYPAPGNLSAKRIQWKLDVVQWLRNFGLHVGSIDEEPWVEVEVWEPFFARLAGEAWRQSDDSQSALPLKRMLWPARFCFRRATSSNFSSGAQTSLLDEPLDFAERWSTMASSLKLDDISHTAQNTPITQDPQPKDQEMPSPLKPEPLESIESLSRIAQYPDLQSTNLVYPTPPDGTATVGLNNPNPCEAFADDSDFGLPHTTQRSSRRNAPGSDISPVQNSGVGVGTGRYDASDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMEGNSLVEDADEAPEALHPPSEPEAEAMVDAEPSPNPPQAIQIHVETHEAHDSPIYDEAPRLSEEPMAPEEPAHSPMDRAGQTISPPLSPVEVKKILFPGPDADDHQQSTDNRGQGHYHPVEFKKKLGDWVQKYGAAGKFWFSSGGSSDTLNQTSAIPTIGMPHRGRSSGNAPGSSKERNKLSLSLAQSENGLRSGSVSSDSSYDSIEIMSEHVPTPAALPSITSLKRKRAPSESDIISIASQEKPLPVAEASPTYAAENSTFLGNFLANFSDWTLTGYFSAFPPQQLPVLFRREGQLEIAQLLVDQITQSSLKHPLDGQIGLFDLESESSSLQALDDTTLLGESSKMDFKRYTSLQDEFVANQPQQQPPQHPPPPKETPKSFISKLSAPHIRVRRGKEYLEALPPAVSFWETFGLEPAHGPKNISAYCIHPQAASKAADVFLTRFGLLYQGCSLGTHTRGDDSVAFEDGLRPWKSETSSYESMMQVLKRTCEQLGSELSQSPATADNNVVYIINPFTHAAALADICSAFWHLFQQLVAGSERRQTRISNELVLQIIPLEFVMSSETMVIPPETDYLNLALEVYSRCRPNDADMSPLLCAPPMLLADALPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWSDMSGSIQRTMSYCLRYRQSSGARPVSEVRNEIWATTKHIMDKFQARWKVQLVTTEPIETDEVEAWASLADQHNKLRPGSLELTILAVNTVPDLILEPPVPPISMAMLNILSSSTPVSTPNPSASVASPEQSGNAATPTSAGPAAYNAPTPTEMSLETDSEAILTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGTTDGDGVFAISVNLIYSPRPPPSHDNVLKDTLSMYRDLGCLARAKGICSVQNNTLPWHVATALRGQELLSYVF
Length1479
PositionKinase
OrganismPenicillium camemberti FM 013
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.398
Instability index60.63
Isoelectric point5.06
Molecular weight161725.04
Publications
PubMed=24407037

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04162
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     786.12|     201|     550|     592|     851|       1
---------------------------------------------------------------------------
   47-  244 (222.69/127.04)	KHLSRL................KDLEARLRGLNCLASCPRRLGLWV....FSPTPEFeslkpLYVRG..SDAESNRIVV....GTTTL....KVSALGSVSSLDLVKGLSSDNQSQHGTQpagqprphQGQPSprrQDGYSSSAAIYASFISAVTGSIGLQLIRR.HAA...............LPLGSRTLFTAVEKSGYESPHINN.DNILS..TSCLttlniqltmsgtitvSA...QTISQA.GI..TR..
  328-  509 (242.97/114.46)	....EVEVWEPFFARLAGEAWRQSDDSQS.....ALPLKRML..WPARfcFRRATSS.....NFSSGAQTSLLDEPLDFaerwSTMAS....................SLKLDDISHTAQ........NTPIT...QDPQPKDQEMPSPLKPEP..LESIESLSRiAQYP...DLQS.TNLVYPTP.PDGTATVGLNNPNPCEAF.ADDSDFGLphTTQR...............SSrrnAPGSDIsPV...QNS
  641-  851 (320.46/180.17)	PPLSPVEVKKILFPGPDADDHQQSTDNRGQGHYHPVEFKKKLGDWVQK..YGAAGKF.....WFSSGGSSDTLNQTSAI....PTIGMphrgRSSGNAPGSSKERNKLSLSLAQSENGLR........SGSVS...SDSSYDSIEIMSEHVPTPAALPSITSLKR.KRAPsesDIISiASQEKPLPVAEASPTYAAENSTFLGNFLANFSDWTL..TGYF...............SA...FPPQQL.PVlfRREG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.01|      23|      25|     569|     593|       2
---------------------------------------------------------------------------
  569-  592 (39.37/25.03)	PEALHPPSEPEaEAMVDAEPSPNP
  609-  631 (43.64/18.99)	PIYDEAPRLSE.EPMAPEEPAHSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.65|      43|     433|     937|    1033|       3
---------------------------------------------------------------------------
  942-  995 (60.87/96.66)	LSAPHIRVrrgkeyLEALPPAVSfwetFGLEPAHGPKNISAYCIHpQAASKAAD
 1153- 1195 (76.78/21.88)	LCAPPMLL......ADALPRAIS....FRLAPERSSPLQDGRSLH.IAYSKSLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04162 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DISHTAQNTPITQDPQPKDQEMPSPLKPEPLESIESLSRI
2) DLQSTNLVYPTPPDGTATVGLNNPNPCEAFADDSDFGLPHTTQRSSRRNAPGSDISPVQNSGVGVGTGRYDASDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMEGNSLVEDADEAPEALHPPSEPEAEAMVDAEPSPNPPQAIQIHVETHEAHDSPIYDEAPRLSEEPMAPEEPAHSPMDRAGQTISPPLSPVEVKKILFPGPDADDHQQSTDNRGQGHYHPVE
3) GLSSDNQSQHGTQPAGQPRPHQGQPSPRRQD
4) LNQTSAIPTIGMPHRGRSSGNAPGSSKERNKLSLSLAQSENG
5) VSTPNPSASVASPEQSGNAATPTSAGPAAYNAPTPTEMSLETDS
405
449
124
706
1320
444
677
154
747
1363










Molecular Recognition Features






MoRF SequenceStartStop




1) EVKKILFPG
2) IYDEA
647
610
655
614