<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04160

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTHPASFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSATNSFPTPASSVSGHPANATSEDVDQGRKSFNMGIQDSAENSGAAPAQQPTQQPTQHRPTDHDRQSSQTESTNDFATGQGQHSTDPDAMDVDTEPTRRADTLSLDLDSLQKELTSAFHLCKSSPIVTGPDPSVDLVSLYGLGSIAHSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPHKQEIGAPGSLRYMTLWPEEEWQNQKVHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETGKKVAPALTAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSTSYGVGMFGIGAR
Length458
PositionHead
OrganismPenicillium camemberti FM 013
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.947
Instability index57.14
Isoelectric point6.44
Molecular weight49378.68
Publications
PubMed=24407037

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04160
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.92|      21|      27|      14|      39|       1
---------------------------------------------------------------------------
   14-   39 (35.15/28.88)	PP....SPSSPAGSLkenhrLPISSEHI.P.Q
   44-   67 (19.89/ 6.50)	PPlmsvNEQSHAANF........TSSHTsPnQ
   72-   90 (35.88/18.14)	PP....NISSPPSS......APMSTQ.V.S.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.94|      25|      27|     198|     223|       2
---------------------------------------------------------------------------
  198-  223 (39.40/33.63)	SLDLDSLQKELTSAFHLCKSSPiVTG
  227-  251 (43.54/31.93)	SVDLVSLYGLGSIAHSVARMDP.VTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.06|      26|      27|     133|     158|       3
---------------------------------------------------------------------------
   95-  120 (43.81/22.04)	SATNSFPTPASSVSGHPANATSEDVD
  133-  158 (46.35/23.77)	SAENSGAAPAQQPTQQPTQHRPTDHD
  162-  187 (43.90/22.10)	SQTESTNDFATGQGQHSTDPDAMDVD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04160 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDRTHPASFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSATNSFPTPASSVSGHPANATSEDVDQGRKSFNMGIQDSAENSGAAPAQQPTQQPTQHRPTDHDRQSSQTESTNDFATGQGQHSTDPDAMDVDTEPTRRADTLSLDLD
2) VHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETGKKVAPALTAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSTSYGVGMF
1
303
202
453










Molecular Recognition Features






MoRF SequenceStartStop




1) DWWEDILGHE
2) KKKRKKDHVAKVST
336
426
345
439