<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04146

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSQYGTNIFLIKGISSIAYQLYEPAPEQAQAFASIAPTIEKSLRDAGRVAHFDTSRRALWHFYIPRHDATQPTAHTEEGGALDHSLDVAVFNLVLTDEGSFEPGHLFKSRPIGQRQTAANTPTHPAFNGSVPDATLRNASSFDNTNTATPSSSDPEGKPTPITSSDGKISITVKIAYEQFISAMLSTVSSPICRSLAAIPLNHCTVLLNSKIIRQGESKNASGTETAVLGIFRIYLTTNGTLVISFSLVLSEGLISMHEVPGTGQAALSSQVLAAPFGVLGSYMGLANGALPYADTIGQTPDTRLWRPRPEPDAKSSQWREICTGMLKGWGLSGHTLQNCTWVALQLSPRKPVDLRAEGRGTPVRNSSPPMIFSWPSILCFRKRSVDPQANQSERTDIALASKEAADSLTEAKTWFQSDTEREESIVQRRKAREAVASAKEAQAQAPAAPQPTDQFPMDPRRAANAAAASAMYPTPPDAVQNPLGIFTAPAADAVTSSPGPPSSVAAPVDGDAPMVNAVVMADTEPDSWEQTDTKRDRVDSTFEGDGNLFGDMGPDMFGDTDITDADFSFFDEDDDNNPLDLNMSAPDTTMTSLPTTTPEPVLLQADILPPTIDEISEETKPKMEAPIFTKPELRHARSTLNDETRGRPTSEISKTLSNKREPSPFDPATVFKKVRASLGRLNNQSLGSPSTVTARKGSVFDSIEFDPVLPLASKKYEQGGRFACRWTPTQSDTSLSLKKPPTTDYLRRHSKLHRKPFRTDNTNARIRSITDGLENSSLQASPDKIEELSSDADDMSLESDVDESPDLMEEPTSPFKASTKRLNLEDDMVSHVTSLRDVESVVEDSDPSLALELPRIARSEVPEVAVAKYFDDPEPLLSQLSLQDDDIITVAQILTEQAISGNLCLRDAQSATFNSPVAPETRRQLASLSRTLSLVLQQAIPAALGDSTQCQFRELIEASDVPLLGPPSRAQPRPVPPRDPNAEPPKPNYLFQIPPPHLEIRRLDSKLSVLPSTISFWETLGLGPSQGAKNITAACVFPNLNGLSDFATTFLGRIRNTYEFLKLGGFDIVNGESGHTTGGLVPWEEERLTGTPTVDGAMHGSSLADRMDSLNQSLLSLEAREKNFVVFIVYIPSHPESIVEACTAFQQLFELHKKALADKRLAPSNELVLQLLPVDFLTAVSGMPTALPIDLIKLALETYDRCTIFGGPMPAPAILLEHTLPRNIDFRLNNTGSSSLMHENTCIHIAYAQSVDERWITAAWTDNRGSQQMTASYNLGRKGKSLSSSLNEVTHEIWETTHDLISRWKVHWRIIITKCGCMDQSEIDFWVGLAQTEQQASVSLTLITVDTSPSLQLVPPAVKVPPTASTSFYTTPVSTPQPSTVSPDQIGTPSTPMKDGSQANASTPTGTPGVADVAEPAEGDAILVDVTDQTWGAVLSHRLGNSTAPGELSTSLISGYLVKRGGTKVEDPPVVMEVNIVHTDGNPRALEALLREMLNYFRGLGTLARARGMVDRETDVRPWHIAAAEKGVRALYLLM
Length1538
PositionKinase
OrganismVerticillium longisporum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.06
Grand average of hydropathy-0.327
Instability index50.23
Isoelectric point5.04
Molecular weight167008.82
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04146
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.11|      16|      17|     940|     956|       1
---------------------------------------------------------------------------
  940-  956 (25.06/15.87)	QQAIPaALGDSTQCQFR
  961-  976 (29.05/14.41)	ASDVP.LLGPPSRAQPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.53|      20|      22|     476|     497|       2
---------------------------------------------------------------------------
  459-  474 (27.76/11.94)	PMDPRRAAN.......AAAASAM
  476-  497 (33.66/22.45)	PTPPDAVQNPL.GifTAPAADAV
  501-  521 (33.11/15.76)	PGPPSSVAAPVdG..DAPMVNAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.11|      22|      23|     601|     623|       3
---------------------------------------------------------------------------
  601-  623 (32.27/23.17)	PE...PVLLQADiLPPTIDEISEETK
  624-  648 (32.84/18.68)	PKmeaPIFTKPE.LRHARSTLNDETR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     285.02|      86|     414|     263|     374|       4
---------------------------------------------------------------------------
   82-  167 (148.35/58.35)	GALDHSLDVAVFNLVLTDE.GSFEPGHLFKSRP.IGQRQTAANTPTHPAFNG.SVPDATLRNASSFD.NTNTATPSSSDPEGKPTPITSS
  280-  369 (136.67/94.93)	GVLGSYMGLANGALPYADTiGQTPDTRLWRPRPePDAKSSQWREICTGMLKGwGLSGHTLQNCTWVAlQLSPRKPVDLRAEGRGTPVRNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.74|      17|      21|     776|     793|       5
---------------------------------------------------------------------------
  776-  793 (24.55/17.10)	LEnSSLQASPDKIEELSS
  800-  816 (31.19/17.35)	LE.SDVDESPDLMEEPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.20|      14|      15|    1364|    1378|       6
---------------------------------------------------------------------------
 1364- 1378 (23.12/18.64)	PPTASTSFYTTPvST
 1381- 1394 (27.08/16.76)	PSTVSPDQIGTP.ST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.68|      19|      25|    1172|    1196|       8
---------------------------------------------------------------------------
 1172- 1191 (29.57/26.56)	LQLLPVDFLTaVSGMPTALP
 1197- 1215 (37.12/16.52)	LALETYDRCT.IFGGPMPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.16|      14|     414|      27|      40|       9
---------------------------------------------------------------------------
   27-   40 (26.42/14.46)	APE.QAQAFASIAPT
  441-  455 (22.73/11.33)	AKEaQAQAPAAPQPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.29|      25|     553|     528|     558|      10
---------------------------------------------------------------------------
  532-  558 (39.17/40.54)	EQTDTkRDrVDSTF..EGDGNLFGDM...GPD
  561-  590 (37.12/16.72)	GDTDI.TD.ADFSFfdEDDDNNPLDLnmsAPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.69|      26|     414|     907|     935|      12
---------------------------------------------------------------------------
  907-  935 (32.18/39.30)	CLrDAQSATFNSPVApETRRQlASLSRTL
 1320- 1345 (47.51/35.60)	CM.DQSEIDFWVGLA.QTEQQ.ASVSLTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04146 with Med13 domain of Kingdom Fungi
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