<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04136

Description Uncharacterized protein (Fragment)
SequenceSCNHHDPFRNVALLDYHPSQNPHRYRYVAATCLITPPTQPTPSTTIAQHVVAAIPVLAMTSRTPMGVQPRPPQQRTLSSSGLTVQRPPHQRTLSAQYLPPSPVRKEPSNLIDLTGDSNDVAVAQNRYGTVPRRGGSRLKLELSNDSTLFQPATESPQNLTPSRLVPKNDASSLADTNSPASTRAGPLDNDNPPMPMPKRRPRFALPTPPKDTKPAVIATKKDGRPKPYSAEIPPDAPRYAPLNRPKADATKVGYGTSATAKESHDMGNADFFSWTGNHPEDRLSDAVIKNGYFDKAPVTQAETTSAKPAIFPALKHKNGLNLLSSIFVGVLNQRKHNGQVVAPSAFKPPPRVTLTDTKREVWMRDLANPAISLPIPVLAMTSRTPMGVQPRPPQQRTLSSSGLTVQRPPHQRTLSAQYLPPSPVRKEPSNLIDLTGDSNDAAVAQNRYGTRRPRFALPTPPKDTTPAVIATKKDGRPKPYSAEIPPDAPRYAPLNRPKADATKVGYGTSATAKESHDMGNADFFSWTGNHPEDRLSDAVIKNGYFDKAPVTQAETTSAKPAIFPALKHKNGLNLLSSIFVGVLNQRKHNGQVVAPSAFKPPPRVTLTDTKREVWMRDLANPAISLRRLSRTIPHGIRGKGLLDHCLNKNVPTERAVWLVRCVGANDLRTVKRKGVNGTVVMGGEAKWLKDWTLYVEQFVESVASAFGEVDWKARVQYAIRLATHLYAEHLVDRDHYMDWLVGGLENSTQSKLPMWILISQIYWKDLLRLRRHGRRLANALLSHLTTIQNDPDRDILAQLSTKLTSLLLPLLSSYPDNFLSPTTWLRCRETLLASIPIDNDAVLSAYKALNSRNEILIASSGKSQPANRQILIKQLDTTFQTLYTNELASSCWNVSEDKGMIVRTVLEWSTSFYRPGQARIYVAASLLRAWASTGVDITTAILESIGAAPPQGTTPKRLFYQLISELVRTGQFNVREYAVWLMGRGGMTSSLDTEPDAPCSTRLLIDLPLSALSSSFIATRANLLRRAAFDVAEEARDIDAAWNFIRHALGLSSNAEVSPVQRRPMPLAKICRAVSNSSRALQTEVGARLLQIFQTDEYESSSDMHLSPTAFNHARSILEAAKDFTTMAEMIKLTSRFPDADILASCADTVNVHLATFAAMNVARNLCDLLLERMKIVNDEQGVRVRPLLVALGALTARLPGLANTIRLATHLYAEHLVDRDHYMDWLVGGLENSTQSKLPMWILISQIYWKDLLRLRRHGRRLANALLSHLTTIQNDPDRDILAQLSTKLTSLLLPLLSSYPDNFLSPTTWLRCRETLLASIPIDNDAVLSAYKALNSRNEVLIASSGKSQPANRQILIKQLDTTFQTLYTNELASSCWNVSEDKRMIVRTVLEWSTSFYRPGQARIYVAASLLRAWASTGVDITTAILESIGTAPPQGTTPKRLFYQLISELVRTGQFNVREYVVWLMGRGGMTSSLDTEPDAPCSTRLLIDLPLSALSSSFIATRANLLRRAAFDVAEEARDIDAAWDFIRHALGLSSDAEISPAQRRPMPLAKICRAVSNSSRALQTEVGARLLQIFQTDDYESSSDVHLSPTAFNHARSILEAAKDFTTMAEMIKLTSRFPDADILASCADTVNVHLPTFAAMNVARNLCDLLLERMKIVNDEQGVRVRPLLVALGALTARLPGLANTSAHLRKELQQIDQSTAIDACSPVSDNMAARLQDAEGELNDEIERLLTGGTSLDRPTMDRLFHTVVTRLEGSWVKDSEKQHAYSALLARLRIFDTQHFDVRMTDWVHHVSIMKTRPTLFDIYPFLISLGCLGLSTIMTTTTIDPSKVVGGQVGCASTYMQEVLQLVVSPLPPKNPLSQEEAYRFYVQQRVAPQQHHRELAVLIRNSLIEYSKLQNSEMSTSAPLARQDLQDDVLDLLRLLVLNDSPTTVQVLGTKLADSPLSEGSWVKDSEKQHAYSALLARLRIFDTQHFDVRMTDWVHHVSIMKTRPTLFDIYPFLISLGCLGLSTIMTTTTIDPSKVVGGQVGCTSTYMQEVLQLVVSPLPPKNALSQEEAYRFYVQQRVAPQQYHRELAVLIRNSLIEYSKLQNSEVSTSAPLARQDLRDDVLDLLRLLVLNDSPTTVQVLGTKLADSPLSEVLASITTRLLAPTRDPNDPMTFETVLELANDFTLPFCQLKLSIGLAASKAGGSSGDEQPASHVDMLSKALDQAVETKNMMWTSVLPYLSEEITDHLKRQAQTRLFSLVPSLKTMSTAGDSSEDTIRLSESLLSVVEAIIRGRPALKATQLNMSMVDKLTELWELLAATELIGKDLRMAIIEHWLPLLLKFITLHTTASEPVLSPTQPASMKPPTTAAANDVRARMLVVLSGIMLELDNISCEEARSGRQLRQTTFDLALFLVDHLPEESRLQCVRAILIGGSLQAPITSDAGIRYLFSYAAPWMEQFMLAHRQTPTPPSNGPPRPKIPISVQGSARLTPYIFRRWELLSEPSPIVGENDTALSLSLFEAIKIQ
Length2520
PositionKinase
OrganismVerticillium longisporum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.06
Grand average of hydropathy-0.215
Instability index44.80
Isoelectric point8.91
Molecular weight278984.26
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04136
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    3012.79|     484|     484|     722|    1205|       1
---------------------------------------------------------------------------
   54-  366 (350.91/231.75)	........IPVLAmtSRTPMGVQPRPPQQRTLSSSGLTVQRPPHQRTlsaqYLPPSPVRKEPSNLIDLTG...DSNDVAVAQnryGTvprrggsrlklelsndstlfqpatespqnlTPsrlvpkndassladtnspastragpldndnppmpmpkRRPRFALPTPPKDTKPAVI...ATKKDGRPKPYSA.EIPPDAP...RY.......APLNRPKAD..ATKVGYGTSATAKESHDMGNADfFSWT.GNHPEDRLSDAVIKNgyFDKAPVTQAETT.................................................................................................................................................................................................................................................................................................................SAKPAIF..PALKHKN..GLNLLSSIFV...GVLNQRK...HN..GQVVAP...........SAFKPPPrvtltdTKR.EVWMRDL
  367-  875 (777.14/525.77)	ANPAISLPIPVLAmtSRTPMGVQPRPPQQRTLSSSGLTVQRPPHQRTlsaqYLPPSPVRKEPSNLIDLTG...DSNDAAVAQnryGT.....................................................................RRPRFALPTPPKDTTPAVI...ATKKDGRPKPYSA.EIPPDAP...RY.......APLNRPKAD..ATKVGYGTSATAKESHDMGNADfFSWT.GNHPEDRLSDAVIKNgyFDKAPVTQAETTSAKPAIFPALKHKNGLNLLsSIFvgVLNQRKHNGQV..VAPS.AFKpPP...RVTLTDTKrevwmrDLANPAISLRRLSRtIPHGirgkGLLDHC...LNKNVPTERAVWLVRCVgaNDLrtvkrkgvngtvvmggeakwLKDWTLYV..EQ..FVESVASAFGEVDWK.ARVQYA............................irlATHLYAEHLVDRDHYMDWLVGG..LENSTQSKLPMWILISQI..YW.KDLLRLRRHGRRLANALLSHLTTIQNDPDRDILAQLSTKLTSLL..LP.LLSSYPDNFLSPTTWLRC..RETLLASIPIDNDAVLSAYKALNSR..NEILIA...........SSGKSQP......ANR.QILIKQL
  876- 1362 (944.38/641.14)	DTTFQTLYTNELA..SSCWNVSEDKGMIVRTVLEWSTSFYRPGQARI....YVAASLLRAWASTGVDITTAILESIGAAPPQ...GT..............................TP.....................................KRLFYQLISELVRTGQFNVREYAVWLMGRGGMTSSLDTEPDAPCSTRLL....IDLPLSALSSSFIATRANLLRRAAFDVAEEARDID.AAWNFIRHALGLSSNAEVSP..VQRRPMPLAKICRAVSNSSRALQTEVGARLL.QIF..QTDEYESSSDMH.LSPT.AFN.HA...RSILEAAK......DFTTMAEMIKLTSR.FPDA....DILASCADTVNVHLATFAAMNVARNL..CDL....................LLERMKIVNDEQGVRVRPLLVALGALTARLPGLANT............................irlATHLYAEHLVDRDHYMDWLVGG..LENSTQSKLPMWILISQI..YW.KDLLRLRRHGRRLANALLSHLTTIQNDPDRDILAQLSTKLTSLL..LP.LLSSYPDNFLSPTTWLRC..RETLLASIPIDNDAVLSAYKALNSR..NEVLIA...........SSGKSQP......ANR.QILIKQL
 1363- 1854 (804.88/544.90)	DTTFQTLYTNELA..SSCWNVSEDKRMIVRTVLEWSTSFYRPGQARI....YVAASLLRAWASTGVDITTAILESIGTAPPQ...GT..............................TP.....................................KRLFYQLISELVRTGQFNVREYVVWLMGRGGMTSSLDTEPDAPCSTRLL....IDLPLSALSSSFIATRANLLRRAAFDVAEEARDID.AAWDFIRHALGLSSDAEISP..AQRRPMPLAKICRAVSNSSRALQTEVGARLL.QIF..QTDDYESSSDVH.LSPT.AFN.HA...RSILEAAK......DFTTMAEMIKLTSR.FPDA....DILASCADTVNVHLPTFAAMNVARNL..CDL....................LLERMKIVNDEQGVRVRPLLVALGALTARLPGLANTsahlrkelqqidqstaidacspvsdnmaarlQD...AEGELN.DEIERLLTGGtsLDRPTMDRL.FHTVVTRLegSWvKD..SEKQHAY...SALLARL.RIFDTQHFDVRMTDWVHHVSIMktRPtLFDIYP..FLIS...LGClgLSTIMTTTTIDPSKVVGGQVGCASTymQEVL.....................................
 1935- 2047 (100.08/58.72)	....................................................................................................................................................................................................DSPTTVQVLgtklADSPLSE.........................................................................................................................................................................................................................................................................................................................gSWvKD..SEKQHAY...SALLARL.RIFDTQHFDVRMTDWVHHVSIMktRPtLFDIYP..FLIS...LGClgLSTIMTTTTIDPSKVVGGQVGCTSTymQEVL.....................................
 2128- 2217 (35.39/14.10)	....................................................................................................................................................................................................DSPTTVQVLgtklADSPLSEVLAS.ITTR...........................................................................................lLAPTrDPN.DPmtfETVLELAN......DFTLPFCQLKL.......................................................................................................................................................................................................................................................................................siglaaskaggSSGDEQP......ASHvDMLSKAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     329.10|      80|     190|    1855|    1934|       2
---------------------------------------------------------------------------
 1855- 1934 (165.58/115.08)	QLVVSPLPPKNPLSQEEAYRFYVQQRVAPQQHHRELAVLIRNSLIEYSKLQNSEMSTSAPLARQDLQDDVLDLLRLLVLN
 2048- 2127 (163.52/113.54)	QLVVSPLPPKNALSQEEAYRFYVQQRVAPQQYHRELAVLIRNSLIEYSKLQNSEVSTSAPLARQDLRDDVLDLLRLLVLN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04136 with Med12 domain of Kingdom Fungi
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