<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04130

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMLDNPMETTTHDGDQVMNHGAISAGDIPMNGPMQVDGLDVDDLFGDGVNLTLPNVRGPTRQLAQRVDEMRTRGCAQGIAWSKSGTIASISPDGRSVQVRYLRADPKTGGWGLSEPTTVDAITASPSTPIVHLAWAATSSNELAVIDAAGRVAILAFSVSLNRPFLTRKWDADHVDDLHAIAGCFWLPLASQHKNYHVFHGPAVKDATAYRYESSFIHAFGPWHPNPAKSALLCVTTSGMLRLFWSQSNNKLEETTLELDSFSSSDDLITHASLHSDKSKPFRETLPVYACSQILDHMYVALATASRQLRLVRVSISWGPPQPDNKLPPSGQPLNPTMTAKHLAISSWMPNGQSGNPIDASMTQISHIELLPSQLDNTGHSWVPMNVLVVRSYLPTTNSPFQEMQSVIDRWEVGHEPSPALHPAFEQMGSRRNSSAGGNDKDPNRLKRLDPVFINKVIVGMQTIHFGKAVGFTFSEGTPCLQVAFSPTNCSVAQIQDDGQVKWNGLHYPLGDIGNSNQDVRCSHRGSHSSGFCCDILPAFTRDWVNELVRMLKVPVDYSEEAHHEALVRNSSLQLCFSILNHLGFNGEFNPRSSSGKFAFLSLNIRNVVILITIASNTPTNMREKLNPLDEHEVIDALCGCAQWSVDLLAYLADSLFALLDDPKFTELLQPRNYSEISNYLRSRSDPSLQLLLCSATRGFLSAVCRRLTHLDQISHRAIEFYDRRAAMQNATDPSGQSKVATIALNKSYQRMQHIISNSHIKVQHFDHLLTTLTSDIRSTYQTAFAGLAAQAQQKNESNGTANTQQGQKQIDAQIRGAQIISELNLLLAAQPPAPFLTVLKKLFGQDLRAFRAQTDPSKLFFADLGLLEVDDAPRVLGARRAAARYVDVFRRVEMTNRAGPREETPEEQLQQRGGRGGPLQWRRCVRCAAVMEDVFGSRPGFTFVLTQQRKCSCGGYWALLPKASIA
Length969
PositionTail
OrganismVerticillium longisporum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.07
Grand average of hydropathy-0.275
Instability index42.42
Isoelectric point6.90
Molecular weight106939.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP04130
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.29|      22|      23|     332|     353|       1
---------------------------------------------------------------------------
  332-  353 (42.48/25.45)	SGQPLNPTMT.AKHLA.ISSWMPN
  356-  379 (30.81/16.55)	SGNPIDASMTqISHIElLPSQLDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.58|      15|      15|     845|     859|       2
---------------------------------------------------------------------------
  845-  859 (26.95/13.90)	LFGQDLRAFRAQTDP
  862-  876 (25.62/12.91)	LFFADLGLLEVDDAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.04|      17|      53|      81|      97|       3
---------------------------------------------------------------------------
   81-   97 (31.25/20.01)	IAW..SKSGTIASISPDGR
  135-  153 (24.79/14.36)	LAWaaTSSNELAVIDAAGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.95|      59|     117|     270|     329|       4
---------------------------------------------------------------------------
  270-  329 (99.90/70.99)	LITHASLHSDKSkPFRETLPVYACSQILDHMYVALATASRQLRLVRVSISWGPPQPDNKL
  390-  448 (105.05/70.36)	LVVRSYLPTTNS.PFQEMQSVIDRWEVGHEPSPALHPAFEQMGSRRNSSAGGNDKDPNRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.40|      33|     133|      24|      56|       5
---------------------------------------------------------------------------
   24-   56 (60.38/36.63)	AISAGDIPMNGPM...QVDGLDVDDLFGDGVNLTLP
  155-  190 (58.02/34.91)	AILAFSVSLNRPFltrKWDADHVDDLHAIAGCFWLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.23|      19|     469|     463|     482|       6
---------------------------------------------------------------------------
  463-  482 (32.91/24.43)	MQTIhFGKAVGFTF..SEGTPC
  934-  954 (33.32/19.30)	MEDV.FGSRPGFTFvlTQQRKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.30|      45|     458|     198|     243|       8
---------------------------------------------------------------------------
  198-  243 (78.51/64.62)	YHVFHGPAVKDATAYRYESSfIHAFGPWHPNPAKSALLCVTTSGML
  659-  703 (76.79/57.32)	FALLDDPKFTELLQPRNYSE.ISNYLRSRSDPSLQLLLCSATRGFL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04130 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPLMLDNPMETTTHDGDQVMNHGAISAGDIPMNGPMQVD
1
39










Molecular Recognition Features






MoRF SequenceStartStop




NANANA