<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04129

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMLDNPMETTTHDGDQVMNHGAISAGDIPMNGPMQVDGLDVDDLFGDGVNLTLPNVRGPSRQLAQRVDEMRTRGCAQGIAWSKSGTIASISPDGRSVQVRYLRADPKTGGWGLSEPTTVDAITASPSTPIVHLAWAATISNELAVIDAAGRVAILAFSVSLNRPFLTRKWDADHVDDLHAIAGCFWLPLASQHKNVRAPSVFGRRLCASTLTISQYHVFHGPAVKDATTYRYESSFIHAFGPWHPNPAKSALLCVTTSGMLRLFWSQSNNKLEETTLELDSFSSSDDLITHASLHSDKSKPFRETLPVYACSQILDHMYVALATASRQLRLVRVSISWGPPQPDNKLPPSGQPLNPTMTAKHLAISSWMPNGQSGNPIDASMTQISHIELLPSQLDNTGQNWVPMNVLVVRSYLPTPNSPFQEMQSVIDRWEVGHEPSPALHPAFEQMGSRRNSNAGGNDKDPNRLKKLDPVFINKVIVGMQTIHFGKAVCIAFSDGSVEYRDRFTMQETYNELSLDRVMTLNQVGFTFAEGSPCLQAAFSPTNCSVAQIQDDGQVKWNGLHYPLGDIGNSNQDAQYAAVIAALTVAASAATFYQVNCDDILAAAKPYADKKCKSIIINHLGFKGEFNPRSSSGKFAFLSLNIRNVVILITIASNTPTNMREKLNPLDEHEVIDALCGCAQWSVDLLAYLADSLFALLDDPKFTELLQPRNYSEISNYLRSRSDPSLQLLLCSATRGFLSAVCRRLTHLDQISHRAIEFYDRRAAMQNATDPSGQSKVATIALNKSYQRMQHIISNSHIKVQDFEHLLTTLTSDIRSTYQTAFAGLAAQAQQKNESNGTANTQQGQKQIDAQIRGAQIISELNLLLAAQPPPPFLTVLKKLFSQDLRAFRAQTDPSKLFFADLGLLEVDDAPRVLGARRAAARYVDVFRRVEMTNKAGPKEETPEEQLQQRGGRGGPLQWRRCVRCAAVMEDVFGSRPGFTFVLTQQRKCSCALVRAIAPDGQEHTPERREALAALKGEGEXDAPSPSPDAEDSTMYMNGGHDFAESSPSADENNASDDADFDMDDDLPNVQSDGAVDALSSSNDSQRPSKRKAGVEVQEDLYIKANPELYGLRRSTRPREQRKIVDSDDSESDVPVNRRNVKRRRVETSQRSSKVNTPIRQASADDSDSDNYGGARAKTLQKKARRQREAQPSSLLAEKRWSSRRAAQTVQQGGYEESDFEDEEDEAAQDAQYYAPEADNSPYIDKVLRHRLKDGLELSFESTRQDFEYYIKWQGKSHLHDTWETAQTLRDVRGYRKLENYFRVVVDHELYIRFGFDIPPETKEQFFLDRERVEEALEDYTKVDRVVAVRDGDEETEYLVKWKGCYYDECTWEVASAISTDFQDKIDQFLDRSSRQWVSDRTETNPDTRTRMTKLEAQPDYIKGGELRTFQLRGLNFLCLNWTRANNVILADEMGLGKTVQSVSFMSWLRNDREQEGPFLIVAPLSVIPAWGDTFDNWSPDMNYVVYLGNEASRQTIRENELMINGNSKKPKFNALITSYEMILHDWSFLQTIKWQALLVDEAHRLKNKESQLYAKLVSFGVPCKILITGTPIQNNLAELSALMDFLNPGKVIIDEELETLTGADTQEKLQDLHTSIAPYILRRTKETVESDLPPKTEKIIRVELSDVQLEYYKNILTRNYAALSDATGQKNSLLNIMMELKKVSNHPYMFGGAEDRVLAGSTRREDQVKGLIASSGKMMLLDQLLTKLKKDGHRVLIFSQMVKMLDILGDYLALRGYKFQRLDGTIAAGPRRMAINHFNAEGSDDFCFLLSTRAGGLGINLMTADTVVIFDSDWNPQADLQAMGRAHRIGQKKPVSIYRLVSKETVEEEVLERARNKLLLEYLTIQAGVTDEGKAFRDEFNKKGLKMDGPSSADDIQWILKMRSQKMFEQTGNQERLEQLDIDSILENAEVTKTKVDDKMNLSSGGIDWDNFMQYTDVKVDDLALDWDQIIPAEELENIKAEEEKRRHEAYLAKVAAESAPRRAAVKNRHNENDRADRVAKKRQREEQQRQEAEEQRALLSDPRRPLNEKETRNLLKAFYRYGAMEDRGDEIVHEARLTERDREFLSSIIDDFTKVCGQALDDNYSKLEEDERKLGKSLTKKDKKAVLIDFGEVRKMNAETAIERPKQLRLLRQVLRKNNDDKSFRLPDASKAAHYSCEWGAREDGMLLVGIDRYGFGAWTQIRDDAGLDLQDKFFLEEHRVEKKEERNKASEKSINSPGAVHLVRRSEYLLSVLQSKHSTDAATLKAVENHHRNNKKHLNGGRRSELGSAAASPAPHLSKKNSSHRDRERERDHHRSRSNVDDRGTPRPESKRKHSGHDEGRIPKHRRTDDSRRSKGHADDRKSPRPEKRRHREEDGDRKHRRPDESRHKDDRRRSHDNSQAHDEDRERRNQALARLADLRLMGDSREEREKDPDAMLWYLLKPVRENFEIILGTTKDKVKSSKERARIFGSELVVIGSFLDREFVRESDKPLKNRFWEFLATLWPVDSTSNPVTADRLSFLYRTIRDREQSDAKKKAQNSNGTAATS
Length2573
PositionTail
OrganismVerticillium longisporum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.07
Grand average of hydropathy-0.667
Instability index44.88
Isoelectric point6.33
Molecular weight290920.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
DNA binding	GO:0003677	IEA:UniProtKB-KW
hydrolase activity	GO:0016787	IEA:UniProtKB-KW
nucleosome-dependent ATPase activity	GO:0070615	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04129
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.77|      33|      35|    2341|    2375|       1
---------------------------------------------------------------------------
 2341- 2375 (60.30/39.60)	RSRSNVDDRGTPRPESKRKHSGHDEGRipKHRRTD
 2379- 2410 (61.03/33.77)	RSKGHADDRKSPRPE.KRRHREEDGDR..KHRRPD
 2412- 2432 (26.44/ 9.29)	.SRHK.DDR...R.RSHDNSQAHDEDR........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.81|      21|     134|      57|      85|       4
---------------------------------------------------------------------------
   57-   85 (29.97/37.35)	NVRGPSrQLAQRVdemrtrgCAQGIAWSK
  197-  217 (37.84/22.08)	NVRAPS.VFGRRL.......CASTLTISQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.05|      32|      34|    1103|    1136|       6
---------------------------------------------------------------------------
 1105- 1127 (30.66/17.60)	..........YIKANPELYGLRRSTRPREQRKI
 1128- 1158 (47.65/27.76)	VDSDDSESD..VPVNRRNVKRRRVETSQRSSKV
 1165- 1192 (34.74/18.01)	ASADDSDSDnYGGARAKT..LQK..KARRQRE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.73|      29|      40|    2004|    2042|       7
---------------------------------------------------------------------------
 2004- 2038 (38.36/43.00)	KAEEEKRRHEAYLAKvAAESAPRRAAvknrhNEND
 2047- 2075 (50.37/25.99)	RQREEQQRQEAEEQR.ALLSDPRRPL.....NEKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.97|      32|     312|     453|     486|       8
---------------------------------------------------------------------------
  453-  486 (51.85/43.17)	RRnsNAGGNDKDPNRLKKLDPVFINKVIVGMQTI
  764-  795 (56.12/39.61)	RR..AAMQNATDPSGQSKVATIALNKSYQRMQHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     367.76|     118|     312|     288|     422|       9
---------------------------------------------------------------------------
  288-  422 (183.42/142.97)	DDLITHASLHSDKS.KP.......FRETLPVYACSQildhmyvALATASRQLRLVRVSISWGPPQPDNklppSGQPLNPtmTAKHLAISSWMPNGQSGNPIDASMTQiSHIELLPS.QLDNTGQnwvPMNVLVVRSYLPTPNSP
  601-  727 (184.33/105.37)	DDILAAAKPYADKKcKSiiinhlgFKGEFNPRSSSG.......KFAFLSLNIRNVVILITIASNTPTN....MREKLNP..LDEHEVIDALCGCAQWSVDLLAYLAD.SLFALLDDpKFTELLQ...PRNYSEISNYLRSRSDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     191.45|      40|      40|    1271|    1310|      10
---------------------------------------------------------------------------
 1235- 1264 (38.60/20.37)	................QYYAPEADNSPYID.....KVLR.H.RLKDGLELSFE
 1265- 1306 (66.05/40.52)	STRQ..........dfEYYIKWQGKSHLHDTWETAQTLR.DVRGYRKLENYFR
 1307- 1345 (52.52/30.59)	VVVD...........hELYIRF.GFDIPPETKE.QFFLD.RERVEEALEDYTK
 1346- 1393 (34.28/17.20)	..VDrvvavrdgdeetEYLVKWKGCYYDECTWEVASAIStDFQD..KIDQFL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.50|      20|     305|    2123|    2148|      11
---------------------------------------------------------------------------
 2088- 2107 (33.91/13.17)	AMEDRGDEIVHEAR.....LTERDR
 2124- 2148 (26.59/22.43)	ALDDNYSKLEEDERklgksLTKKDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.76|      14|      21|    1956|    1975|      12
---------------------------------------------------------------------------
 1956- 1975 (17.31/24.42)	TKTKVDDkmnLSsggIDWDN
 1980- 1993 (27.45/14.52)	TDVKVDD...LA...LDWDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.41|      26|      32|    2277|    2302|      16
---------------------------------------------------------------------------
 1074- 1094 (29.87/16.61)	...QSDGAVDA..LSSSNDSQRPSKR
 2277- 2302 (41.39/26.46)	SVLQSKHSTDAATLKAVENHHRNNKK
 2310- 2335 (43.15/27.97)	SELGSAAASPAPHLSKKNSSHRDRER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.73|      32|      33|    1644|    1676|      17
---------------------------------------------------------------------------
 1644- 1663 (15.93/11.55)	...............ILRRTKETVeSDLPPKTEKI
 1664- 1697 (45.54/34.56)	IRVELSDVQLEYYknILTRNYAAL.SDATGQKNSL
 1700- 1721 (29.25/18.29)	IMMELKKVSNHPY..MFGGAEDRV...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.43|      18|      35|    1518|    1535|      18
---------------------------------------------------------------------------
 1518- 1535 (29.72/16.93)	QTIRENELMINGNSK.KPK
 1538- 1551 (16.39/ 6.01)	ALITSYEMILHDWS.....
 1554- 1572 (24.32/12.50)	QTIKWQALLVDEAHRlKNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.17|      16|      65|     940|     957|      20
---------------------------------------------------------------------------
  940-  956 (25.44/21.43)	GpKEETPE..EQLQQRGGR
 1004- 1021 (23.73/ 8.47)	G.QEHTPErrEALAALKGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.08|      12|      20|    2159|    2170|      23
---------------------------------------------------------------------------
 2159- 2170 (20.63/12.65)	RKMNAETAIERP
 2181- 2192 (21.45/13.49)	RKNNDDKSFRLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04129 with Med16 domain of Kingdom Fungi
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