<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04126

Description Glucose-6-phosphate 1-dehydrogenase
SequenceMPTQVAQHTPLADALTEAIQAKVIEVGLAQSNDASALAEYITLTLVNGKNQEDIVTELSTELLGLPANDPIVITLVAWMFEQVEVLNVQLNGAAQPSQVAEEPNLNAQDASANVEMDTDMNAGDASELNAPTGPRSMRNGNNLRGGREKRMLGKALDRTGDSVLHRTRGNDRINSHARGPPTGPRGNMRGGGRGMNARAANIQAGMNAMGGMNMRANGPPGMGGMNAGWGMPQGGEMDLMAMMQQQSQMMAQLQQQIMNGPGGGQQRHGKSLFDRTQRPQRNNKQHHNSNNHNSNKPEGEGEAGAEGEDVDMAKREPPNPEDTVCKFNLRCTNRDCKFGHQSPAAPPNTHVDMNDVCTFGAACKNRKCVGRHPSPAAKLAHQGEQDCKFFPNCHNPQCPFKHPDMPLCRNGSGCTTPGCKFTHVKVKCRFNPCKNPHCAYSHDEGQQGGFKDKVWTPEGGAAHVSERKFVLEGEGDESMVPEDSAMGQEDDAVVKQELITTLELKDNTVIIVLGASGDLAKKKTYPALFGLYRNQFLPKDIKIVGYARTKMEHDEYIRRIRSYMKTPTKEIEQQLNDFCNLCTYVSGQYDKDESFLALNDHLEKLESGKPETHRLFYMALPPSVFTIVSQHLKKCCYPSKGIARVVVEKPFGKDLASSRELQKSLEPDWKEDELFRIDHYLGKEMVKNILILRFGNSFFGATWNRQNIDNVQITFKEPFGTEGRGGYFDEFGIVRDVMQNHLLQVLTLLAMERPISFSAEDIRDEKVRVLRAIPAIEPKNVIIGQYGKSLDGSKPSYKEDDTVPKDSRCPTFCALVAYIKNERWDGVPFIMKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDCLKGDHSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMEYPYGSRGPAVLDDFTSSYGYKFSDAAGYQWPTTAASAPNKLDVKVNGGAMAVDSPAALDKGKGAAAGTSDAAAQNGHGDKTVPPPNAQDAQRGTSTVSLPNRSRMNDLPDEIQHITQGFIPLSTIILRLAQATHDDLEKAIMDAARIKYSPPAINGSATGGGDPPDDSSEANKTRKLTLLKFAQDAHTKWVKALVITDWSRKASTVSKLIDLKAHLDKKRSLFDFTLTELIELKRSLGQARLPRPDLKTALQILTTGEAPWIPEPGYIPPPSLTPEEQLKWIEELNTLLSLRLNLDDYDKIPHQFKNYTIESGRVTFKVKGEFEVDLTIADEDFEKQFWFIDFRFDFTPSSERLSDALVAYLEGQVNDVLSREGLEGCYRFLHEFVLTHKINELKRQAIDLVRNSWTGNLKVEPLNRALAIQYWTSRYGPQAPKSWVMVAVQSGKQKNGLPDPKHPSHLVARWYRDNKEIKDVKLHLNIQEISAEALLKSAIAKHVEHILSSIHDELAAAPRFVNRQAFMRLDISRSEPLDSSLKMQLGGKKMVKLLIEPITGFAAIQPHTRYGLQGETRINHGGKDPAEDGVACLENIRWGYVVDEFNRRGRSCGWAMTKIPVGNEEVKRLIKTREPFQPVFFQRQGLGQDWFVLMSLSLAGDEWWLIEVTRNGASRAVTTSIQLPFSKGQPELNDKFWNNLTSLAAGMISQAIELGELKKNRIDHTAKDMQSRCLTQQIRIPVIFIRLAHILDSPDSLAQTRAQDRRVQSSAPAWAADTVEVHFRGTKGSSAANSAGNDTTGLGICVDAVLKVKDKHKFKQLQARIDKNVAFDRRTGQFVFHIRGSVGKPVLQALADHIKSIDRLVGFLDAMRCAKGAVQCTEVGLGKVKFSYSDIVLPGETSEPRQWTAVLDMSRSGTRLILEPDNPHLRILDLLTKVVNTEKGLRVMMAYMTDVLPILRVFDTLEKKWEEVEAAGQGHIELLTPAADWFAIRYSLPSTAGPARQVTIDVRSKERQAQPYWFASRKQRGPPSPADDEFKAVLKSVWESRGENWRGLTTGAVAQMGMGVFEMIQAMDDAVRAYATGNGPADDNASTAGLPTQVSQVFSSQGSGNGTPQTSQAQSQKQASQASQGQQPQRPRPNQTPNQNQMRKPSFGKQGGGAKGPVGGKNAPVVVLD
Length2126
PositionTail
OrganismVerticillium longisporum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.07
Grand average of hydropathy-0.510
Instability index40.99
Isoelectric point8.02
Molecular weight236054.38
Publications









Function






Annotated function

Catalyzes the rate-limiting step of the oxidative pentose-
phosphate pathway, which represents a route for the dissimilation of
carbohydrates besides glycolysis. 

Catalyzes the rate-limiting step of the oxidative pentose-
phosphate pathway, which represents a route for the dissimilation of
carbohydrates besides glycolysis. The main function of this enzyme is
to provide reducing power (NADPH) and pentose phosphates for fatty acid
and nucleic acid synthesis. 


ECO:0000256	RuleBase:RU362120
ECO:0000256	ARBA:ARBA00002437

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
glucose-6-phosphate dehydrogenase activity	GO:0004345	IEA:UniProtKB-EC
NADP binding	GO:0050661	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
glucose metabolic process	GO:0006006	IEA:UniProtKB-KW
pentose-phosphate shunt	GO:0006098	IEA:UniProtKB-UniPathway
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04126
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.23|      17|      18|     194|     211|       1
---------------------------------------------------------------------------
  194-  209 (25.51/ 9.45)	GMNARAANIQAG..MNAM..
  211-  227 (27.93/11.55)	GMNMRANG.PPG..MGGMnA
  245-  262 (21.79/ 7.47)	QQSQMMAQLQQ.qiMNGP.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     116.44|      17|      18|     393|     409|       2
---------------------------------------------------------------------------
  340-  358 (18.70/ 6.40)	HQSPAAPPNtHVDMnDVCT
  363-  378 (28.56/13.99)	CKNRKCVGR.HPS..PAAK
  393-  409 (39.23/22.19)	CHNPQCPFK.HPDM.PLCR
  414-  429 (29.94/15.05)	CTTPGCKFT.HVKV.K.CR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.92|      20|      20|    2065|    2084|       5
---------------------------------------------------------------------------
 2037- 2061 (23.00/11.13)	PADDNASTaglPTQVSQvfSSQGSG
 2065- 2084 (34.45/21.05)	PQTSQAQS...QKQASQ..ASQGQQ
 2088- 2107 (36.47/22.80)	PRPNQTPN...QNQMRK..PSFGKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     504.61|     168|     715|     682|     884|       6
---------------------------------------------------------------------------
  682-  884 (256.22/266.04)	GKEmvKNILILRFGNSFFGATWNRQN..IDNVQItfkepfgtegrggyfdefgivrdvmqnHL.LQVLT...LL..AMERPISFSAEDIRDEkvrvLRAIPAIEPKNVIIG...QYGKSLDGS............................KPSYKEDDTVPKDSRCPTfCALVAYIKNERWdG..VPFIMKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVMRIQP.NESVYIKMNSKLPG
 1400- 1609 (248.39/181.11)	GKQ..KNGLPDPKHPSHLVARWYRDNkeIKDVKL...........................HLnIQEISaeaLLksAIAKHVEHILSSIHDE....LAAAPRFVNRQAFMRldiSRSEPLDSSlkmqlggkkmvklliepitgfaaiqphtRYGLQGETRINHGGKDPA.EDGVACLENIRW.GyvVDEFNRRGRSCGWAMTKIPVGNEEVKRLIKTREPFQPVFFQRQGlGQDWFVLMSLSLAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.09|      12|      20|    1161|    1172|       7
---------------------------------------------------------------------------
 1161- 1172 (19.87/14.95)	TVSKLIDLKAHL
 1182- 1193 (19.22/14.18)	TLTELIELKRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.66|      13|      16|     454|     466|       9
---------------------------------------------------------------------------
  454-  466 (24.68/13.55)	VWTPEGGAAHVSE
  470-  482 (22.98/12.08)	VLEGEGDESMVPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.10|      11|      48|     131|     146|      10
---------------------------------------------------------------------------
  131-  146 (19.09/20.76)	PTGPRsmrngNNLRGG
  181-  191 (26.01/13.28)	PTGPR.....GNMRGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.36|      16|      16|     265|     280|      12
---------------------------------------------------------------------------
  265-  280 (28.20/17.84)	QQRHGKSLFDRTQRPQ
  283-  298 (29.16/18.72)	NKQHHNSNNHNSNKPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.98|      16|      16|    1707|    1722|      13
---------------------------------------------------------------------------
 1707- 1722 (26.57/17.30)	AQT.RAQDRRVQSSAPA
 1725- 1741 (22.42/13.25)	ADTvEVHFRGTKGSSAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.96|      31|     647|     563|     609|      14
---------------------------------------------------------------------------
  563-  593 (56.92/58.23)	YMKTPTKEIEQQLNDFCNLCTYVSGQYDKDE
 1223- 1253 (54.04/25.80)	YIPPPSLTPEEQLKWIEELNTLLSLRLNLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.17|      11|      22|    1278|    1288|      15
---------------------------------------------------------------------------
 1278- 1288 (18.31/ 9.48)	EFEVDLTIADE
 1298- 1308 (20.86/11.80)	DFRFDFTPSSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.14|      14|      22|    1318|    1332|      16
---------------------------------------------------------------------------
 1318- 1332 (18.28/15.67)	LEGQVNDvLSREGLE
 1343- 1356 (22.86/14.38)	LTHKINE.LKRQAID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.89|      13|      25|    1970|    1983|      18
---------------------------------------------------------------------------
 1970- 1983 (22.60/16.30)	WfASRKQ..RGPPSPA
 1995- 2009 (20.29/ 8.83)	W.ESRGEnwRGLTTGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.21|      18|      20|    1842|    1861|      19
---------------------------------------------------------------------------
 1842- 1861 (25.52/20.69)	SDIVLPGETSEPRqwTAVLD
 1865- 1882 (31.69/17.38)	SGTRLILEPDNPH..LRILD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04126 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AALDKGKGAAAGTSDAAAQNGHGDKTVPPPNAQDAQRGTSTVSLPNRSRMNDLPDEIQ
2) DAVRAYATGNGPADDNASTAGLPTQVSQVFSSQGSGNGTPQTSQAQSQKQASQASQGQQPQRPRPNQTPNQNQMRKPSFGKQGGGAKGPVGGKNAPVVVLD
3) NGAAQPSQVAEEPNLNAQDASANVEMDTDMNAGDASELNAPTGPRSMRNGNNLRGGREKRMLGKALDRTGDSVLHRTRGNDRINSHARGPPTGPRGNMRGGGRGMNARAANIQAGMNAMGGMNMRANGPPGMGGMNAGWGMPQGGEMDLMAMMQQQSQMMAQLQQQIMNGPGGGQQRHGKSLFDRTQRPQRNNKQHHNSNNHNSNKPEGEGEAGAEGEDVDMAKREPPN
1012
2026
91
1069
2126
319










Molecular Recognition Features






MoRF SequenceStartStop




1) MRKPSFGKQGG
2099
2109