<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04125

Description Glucose-6-phosphate 1-dehydrogenase (Fragment)
SequenceQSEAGDNDLISERSCGKFLLRHILSSPVFSESLPLHPTAIMSELTSAASTLELKDNTVIIVLGASGDLAKKKTYPALFGLYRNQFLPKDIKIVGYARTKMEHDEYIRRIRSYIKTPTKEIEQQLNDFCNLCTYVSGQYDKDESFLALNDHLEKLESGKPETHRLFYMALPPSVFTIVSQHLKKCCYPSKGIARVVVEKPFGKDLASSRELQKSLEPDWKEDELFRIDHYLGKEMVKNILILRFGNSFFGATWNRQNIDNVQITFKEPFGTEGRGGYFDEFGIVRDVMQNHLLQVLTLLAMERPISFSAEDIRDEKVRVLRAIPAIEPKNVIIGQYGKSLDGSKPSYKEDDTVPKDSRCPTFCALVAYIKNERWDGVPFIMKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDCLKGDHSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMEYPYGSRGPAVLDDFTSSYGYKFSDAAGYQWPTTAASAPNKLLTFQMDDPFRTRPGSTIRPQPALGLINMENGVQNGAHSNHDRDVKVNGGAVAVDSPAALDKGKGAAAGTSDAAAQNGHGDKTVPPASAQDAQRGTSTVSLPNRSRMNDLPDEIQHITQGFIPLSTIILRLAQATHDDLEKAIMDAARIKYSPPAINGSATGGGDPPDDSSEANKARKLTLLKFAQDAHTKWVKALVITDWSRKASTVSKLIDLKAHLDKKRSLFDFTLTELIELKRSLGQARLPRPDLKTALQILTTGEAPWIPEPGYIPPPSLTPEEQLKWIEELNTLLSLRLNLDDYDKIPHQFKNYTIKSGRVTFTVKGEFEVDLTIADEDFEKQFWFIDFRFDFTPSSERLSDALVAYLEGQVNDVLSREGLEGCYRFLHEFVLTHKINELKRQAIDLVRNSWTGNLKVEPLNRALAIQYWTSRYGPQAPKSWVMVAVQSGKQKNGLPDPKHPSHLVARWYRDNKEIKDVKLHLNIQEISAEALLKSAIAKHVEHILSSIHDKLAAAPRFVNRQAYMRLDISRSEPLDSSLEMQLGGKKMVKLLIEPITGFAAIQPHTRYGLQGETRINHGGKDPAEDGVACLENIRWGYVVDEFNRRGRSCGWAMTKIPVGNEEVKRLIKTREPFQPVFFQRQGLGQDWFVLMSLSLAGDEWWLIEVTRNGASRTVTTSIQLPFSKGQPELNDKFWNNLTSLAAGMISQAIELGELKKNRIDHTAKDMQSRCLTQQIRIPVIFIRLAHILDSPDSLAQTRAQDRRVQSSAPAWPADTVEVHFRGTKGSSAANSAGNDTAGLGISVDAVLKVKDKHKFKQLQARIDKNVAFDRRTGQFVFHIRGSVGKPVLQALADHIKSIDRLVGFLDAMRCAKGAVQCTEVGLGKVKFSYSDIVLPGETGEPRQWTAVLDMSRNGTRLILEPDNPHLRILDLLTKVVNTEKGLRVMMAYMTDVLPILRVFDTLEKKWEEVEAAGQGHIELLTPAADWFAVRYSLPSTAGPARQLTIDVRSKERQAQPYWFASRKQRGPPSPADDEFKAVLKGVWDSRGENWRGLTTGAVAQMGMGVFEMIQAMDDAVRAYATGNGPADDNASTAGLPTQVSQVFSSQGSGNGTPQTSQAQSQKQASQASQGQQPQRPRPNQTPNQNQMRKPSFGKQGGGAKGPVGGKNAPVVVLD
Length1717
PositionTail
OrganismVerticillium longisporum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.08
Grand average of hydropathy-0.428
Instability index41.39
Isoelectric point8.61
Molecular weight191822.19
Publications









Function






Annotated function

Catalyzes the rate-limiting step of the oxidative pentose-
phosphate pathway, which represents a route for the dissimilation of
carbohydrates besides glycolysis. 

Catalyzes the rate-limiting step of the oxidative pentose-
phosphate pathway, which represents a route for the dissimilation of
carbohydrates besides glycolysis. The main function of this enzyme is
to provide reducing power (NADPH) and pentose phosphates for fatty acid
and nucleic acid synthesis. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
glucose-6-phosphate dehydrogenase activity	GO:0004345	IEA:UniProtKB-EC
NADP binding	GO:0050661	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
glucose metabolic process	GO:0006006	IEA:UniProtKB-KW
pentose-phosphate shunt	GO:0006098	IEA:UniProtKB-UniPathway
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP04125
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.74|      22|      24|    1643|    1666|       1
---------------------------------------------------------------------------
 1643- 1666 (34.74/23.29)	SQvfSSQGSGNGTPQTSQAQSQKQ
 1668- 1689 (40.00/20.89)	SQ..ASQGQQPQRPRPNQTPNQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.94|      27|      29|    1448|    1475|       2
---------------------------------------------------------------------------
 1448- 1475 (42.06/30.48)	TAVLDmSRNGTRLILE..PDN.PHLRILDLL
 1476- 1505 (36.88/21.29)	TKVVN.TEKGLRVMMAymTDVlPILRVFDTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.43|      25|      25|     622|     646|       3
---------------------------------------------------------------------------
  593-  620 (31.39/19.74)	NGGAVAVDSPAAldkGKGAAAG...TSDAAA
  622-  646 (42.09/29.59)	NGHGDKTVPPAS...AQDAQRG...TSTVSL
  648-  674 (31.96/20.26)	NRSRMNDLPD.E...IQHITQGfipLSTIIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.35|      16|      18|     752|     769|       4
---------------------------------------------------------------------------
  752-  767 (26.27/18.78)	TVSKLIDLKAHLDKKR
  773-  788 (24.08/ 9.75)	TLTELIELKRSLGQAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.77|      12|      24|     789|     800|       5
---------------------------------------------------------------------------
  789-  800 (20.27/ 9.37)	LPRPDLKTALQI
  815-  826 (22.50/11.27)	IPPPSLTPEEQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.91|      51|    1034|     304|     397|       6
---------------------------------------------------------------------------
  333-  397 (76.35/125.24)	GQYGKSLDGSkpsykeddtVPKdsrcPTFCALVAYIKN.ERWDGVPFIMKAGKAlNEQKTEI...RIQF
 1376- 1430 (81.55/42.39)	GQFVFHIRGS.........VGK....PVLQALADHIKSiDRLVGFLDAMRCAKG.AVQCTEVglgKVKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.55|      10|      31|    1529|    1542|       8
---------------------------------------------------------------------------
 1529- 1542 (15.59/22.37)	WFAVRyslpSTAGP
 1561- 1570 (21.96/14.22)	WFASR....KQRGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.03|      10|      33|    1145|    1154|       9
---------------------------------------------------------------------------
 1145- 1154 (22.06/13.06)	FNRRGRSCGW
 1181- 1190 (20.96/12.01)	FQRQGLGQDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.51|      26|      32|     840|     869|      10
---------------------------------------------------------------------------
  840-  869 (34.34/38.77)	LNLDDYDkIPHQFknYTIkSGRVTFTVKGE
  874-  899 (49.17/34.07)	LTIADED.FEKQF..WFI.DFRFDFTPSSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.48|      41|    1034|     190|     239|      11
---------------------------------------------------------------------------
  190-  239 (55.92/55.31)	GIARVV...VEKPFGK...........DLAS........SRELQkSLEPDwkedelfRIDHyLGKEMVKNIL
 1212- 1274 (51.56/28.51)	GASRTVttsIQLPFSKgqpelndkfwnNLTSlaagmisqAIELG.ELKKN.......RIDH.TAKDMQSRCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.33|      17|      32|     682|     700|      13
---------------------------------------------------------------------------
  682-  700 (25.22/21.27)	DDLEKAimDAAR....IKYSPPA
  713-  733 (23.11/12.21)	DDSSEA..NKARkltlLKFAQDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.49|      14|    1021|      22|      37|      15
---------------------------------------------------------------------------
   22-   37 (22.62/20.82)	HILSSpvFSESLPLHP
 1045- 1058 (25.88/15.38)	HILSS..IHDKLAAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.76|      20|     208|    1111|    1130|      17
---------------------------------------------------------------------------
 1111- 1130 (36.75/24.63)	GLQGETRINHGGKDPAEDGV
 1325- 1344 (34.02/22.17)	GTKGSSAANSAGNDTAGLGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.14|      14|      25|     909|     923|      23
---------------------------------------------------------------------------
  909-  923 (18.28/15.95)	LEGQVNDvLSREGLE
  934-  947 (22.86/14.65)	LTHKINE.LKRQAID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04125 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DAVRAYATGNGPADDNASTAGLPTQVSQVFSSQGSGNGTPQTSQAQSQKQASQASQGQQPQRPRPNQTPNQNQMRKPSFGKQGGGAKGPVGGKNAPVVVLD
2) LLTFQMDDPFRTRPGSTIRPQPALGLINMENGVQNGAHSNHDRDVKVNGGAVAV
3) SPAALDKGKGAAAGTSDAAAQNGHGDKTVPPASAQDAQRGTSTVSLPNRSRMNDLPDEIQ
1617
546
601
1717
599
660










Molecular Recognition Features






MoRF SequenceStartStop




1) MRKPSFGKQGG
1690
1700