<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04104

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGVCGSAIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVNSHSSHVISAQSTSSLPTTPAPQPPTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGTPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKDVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFVFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDSEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKAKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGTAPPSTEERKKKSTKGKKRSQPATKSEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQSSQGYTSYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQPQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2165
PositionKinase
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.07
Grand average of hydropathy-0.515
Instability index57.92
Isoelectric point6.77
Molecular weight241876.44
Publications
PubMed=15057822
PubMed=22673903

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	ISO:RGD
nucleus	GO:0005634	ISO:RGD
ubiquitin ligase complex	GO:0000151	IDA:RGD

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	ISO:RGD
protein C-terminus binding	GO:0008022	ISO:RGD
protein domain specific binding	GO:0019904	ISO:RGD
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	ISO:RGD
thyroid hormone receptor binding	GO:0046966	ISO:RGD
transcription coactivator activity	GO:0003713	ISO:RGD
transcription coregulator activity	GO:0003712	ISO:RGD
transcription factor binding	GO:0008134	ISO:RGD

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	ISO:RGD
canonical Wnt signaling pathway	GO:0060070	ISO:RGD
embryonic brain development	GO:1990403	ISO:RGD
embryonic neurocranium morphogenesis	GO:0048702	ISO:RGD
embryonic organ development	GO:0048568	ISO:RGD
endoderm development	GO:0007492	ISO:RGD
heart development	GO:0007507	ISO:RGD
neural tube closure	GO:0001843	ISO:RGD
neural tube development	GO:0021915	ISO:RGD
oligodendrocyte development	GO:0014003	ISO:RGD
positive regulation of transcription by RNA polymerase II	GO:0045944	ISO:RGD
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:RGD
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
post-anal tail morphogenesis	GO:0036342	ISO:RGD
protein ubiquitination	GO:0016567	IDA:RGD
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
Schwann cell development	GO:0014044	ISO:RGD
somitogenesis	GO:0001756	ISO:RGD
spinal cord development	GO:0021510	ISO:RGD
stem cell population maintenance	GO:0019827	ISO:RGD
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04104
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     168.04|      15|      15|    2031|    2045|       1
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 2031- 2045 (35.88/15.86)	QQQQQQQ..QQQQQQ...QQ
 2048- 2062 (35.88/15.86)	QQQQQQQ..QQQQQQ...QQ
 2067- 2083 (30.12/11.97)	QQQQQQQilRQQQQQ...QQ
 2084- 2098 (35.88/15.86)	QQQQQQQ..QQQQQQ...QQ
 2099- 2116 (30.26/12.06)	QPQQQQP..HQQQQQaapPQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     825.13|     219|     230|     350|     578|       2
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  176-  407 (298.81/154.91)	KKKNTAdpFTEWTQI....ITKYLWEQLQKMAEYYR..PGPAGSGVCGSAIGPLPHDVEM....AIRQWDYNEKLalfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVNSHSShvISAQSTSSlPTTPAPQPPTSNTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH.......YSLT.DSR..IKTGSPLDHlPIAPSNLPM
  408-  642 (335.51/160.28)	PEGNSA..FTQQVRAKLReIEQQIKERGQAVEVRWS..FDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..VASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCE..LIRHdvfshnmYTCTlISRgdLAFGTPGPR.PPSPFDDPA
  645-  814 (190.81/84.66)	PERKEA...EGSSSSKLE..DPGLSE.SMDIDPSSSvlFEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKDV.....kPPPKEKIEGtLG........ILYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ..........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     290.99|     100|     148|     876|    1023|       3
---------------------------------------------------------------------------
  879-  991 (147.37/121.46)	DLME....YSLSISGL.IDFAIQLLNELSVVEAELL.....LKSSDLVGSYTtslCLCivAVLRHYhaCLILNQDQMAQ.VFEGLCGVVKHGmNRSDG..SSAERCILAYLYdlytsC.SH..LKSKFG
 1025- 1107 (102.05/103.74)	DTLEnpaaHTFTYTGLgKSLSENPANRYSFVCNALMhvcvgHHDPDRVNDIA...ILC..AELTGY..CKSLSAEWLG..VLKALCCSSNNG.....................................
 1287- 1337 (41.57/ 8.81)	......................................................................ICQQEWVGErCLKSLCEDSN...DLQDPvlSSAQAQRLMQLI.....CyPHrlLDSEDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     422.65|     123|     127|    1688|    1814|       4
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 1640- 1743 (99.12/42.43)	LPLPKQNR..D...............................................................................vitcepqgslidtkgnkiagfdsifkkeglqvstkqkisPWELFEGL..KP.STAPLSWAWFGTVRVDRRVAR.GEEQQRLLLYHT.HLRPRPRAYYLEP
 1744- 1847 (152.28/79.91)	LPLPPEDE..EPPAPALLePEKKAPEPPKTdkPGTAPPSTEE..............RKKKST..KGKK.RSQPATKSEDYGMgPGRSGPY...................................gvtvPPDLLHHA..NPgSISHLSY.........RQSSM.G....................LYTQN
 1848- 1982 (171.26/78.87)	QPLPAGGPrvDPYRPVRL.PMQKLPTRPTY..PGVLPTTMTTvmglepssyktsvyRQQQPTvpQGQRlRQQLQAKIQSQGM.LGQSSVH...............................................qmTP.SS...SYGLQSSQGYTSYVSHvGLQQHTGPADPTrHLQQRPSGYVHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.41|      34|     200|    1234|    1267|       5
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 1234- 1267 (61.64/33.74)	AELKGS..GFTVPGGT.EELPEEEGGG.G..SSGRRQGGR
 1398- 1427 (28.85/11.66)	....GS..S...SGSTaSNMPSSSKAK.PvlSSLERSGVW
 1434- 1468 (42.92/21.13)	AKLPTSvqGHVLKAAG.EEL..EKGQHlG..SSSRKERDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.95|      34|     127|    1995|    2029|       6
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 1995- 2029 (55.57/32.84)	RFSHQTLQQTPMMGTMTPLSAQgVQAGVRSTSILP
 2124- 2157 (59.38/31.00)	QFQRQGLQQTQQQQQTAALVRQ.LQQQLSNTQPQP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04104 with Med12 domain of Kingdom Metazoa
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