<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04096

Description Mediator complex subunit 26
SequenceMISLHGISGHPMSEIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLIEPVHQNEVALRALAGAAGSANGGAHNCRPELGVAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLELSENEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQPLDRADEPPGPPYPRGSPRCSISPRNSRHEGSFARHRSSYIPKGPVSSPSPRPQPLDTTQVPSPLPLAQPPTPPVRRLDLLPNAESPVHWPEQPEGHPRLTGPACRAGLSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQLPRTELEQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWPGVNGCEDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length578
PositionUnknown
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.03
Grand average of hydropathy-0.844
Instability index62.09
Isoelectric point9.29
Molecular weight63326.56
Publications
PubMed=15057822

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISO:RGD

GO - Biological Function
transcription coregulator activity	GO:0003712	ISO:RGD

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04096
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     400.21|      78|      84|     222|     302|       1
---------------------------------------------------------------------------
  103-  175 (89.04/32.90)	.P.ELGVAGAP...KSIHDLK..NRNDiqRL.PGQRLDRlGSRK.....R..RGDQRDLGHPG..........PPHKVSKGSPDPlvpnaSPLPTNGI
  181-  221 (62.56/20.86)	S...LP..............SPLD.GS..GH.LGP...D.GS.R.....L..ELS.ENEKH........STKI...PVNAVRPRP.....S.......
  222-  302 (147.54/64.70)	SP.GLGKPPVPCLQTKAAQLQPLDRAD..EP.PGPPYPR.GSPR.....C..SISPRNSRHEGSFArhrSSYIPKGPVSSPSPRP.....QPLDTTQV
  304-  382 (101.06/38.37)	SPlPLAQPPTPPVR....RLDLLPNAE..SPvHWPEQPE.GHPRltgpaCraGLSPDSSKADSDAA...SS...GGSDSKKKKRY.....RPRDYT.V
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.55|      36|      59|     408|     443|       2
---------------------------------------------------------------------------
  408-  443 (58.95/27.90)	MTRQIRPLTQKEPVRADSP....VPTEQLPRTELEQQEAK
  468-  501 (34.32/13.31)	LSRQSSLLSSSG...AQTPgahhFMAEYLKQEESSRQ...
  503-  536 (48.28/21.58)	.ARQPHVLLP.LPTPTDLP....GLTREVTQDDLDRIQAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04096 with Med26 domain of Kingdom Metazoa
Unable to open file!