<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04091

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLVKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPVDDSLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMIIGTNNTSIGTPSPGTPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKISNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPALSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGLRSPAGENSDEHYSKDHDMKMEEHSVMARLGLGSGATHIFDDVDKSDFKSDPASEFPIFSPMPGESCENINPSLSRRLSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKGTTESGVGDEGQKARKTKQEVFPTPENVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILNDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFFPQGTGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVNTMKNEDFGMRGLRRDGNAEDAWATSQNSKSYGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPSSGSVAEMNNLLDNIAKATIEVFQQSADLNNNASNSGMSLFNPNTIGSVDPSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDTKARQMMHEALQLRLNLVGGMFDTVQRSTQGTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSSASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQQHFLLYHTHTMPKPRSYYLEPLPLPPEEEEEELTSPVSQEPERKSAELSDQGKATADEEKKTKGRKRKTKSSSRIDEYQQTNLYRVPPNYSPMSSQMTHHPQPALWGYNLVSQPQQPSFFLQNPSLNPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMLQPPSLHAVTSQQQLLQMKLLQQQQQQQQQQQQQQQRLLRQAQTRPFQQGQPGDQAALFTAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQAAQQQPGGVVLSPSYNSRAYPAAHSSPALMERLRQLQQQPSGYVQQQASPYLQPVAGSQRLNHQALQQSPLVGGGIDAVLTPAHPNLPSVPLPQDPMRPRQQQVRQQQRLLQMQQPQQAPQPQQPSQTQSQALGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPCAHPSHF
Length2185
PositionKinase
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy-0.434
Instability index57.97
Isoelectric point7.61
Molecular weight244314.30
Publications
PubMed=19468303

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04091
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     263.77|      28|      32|    1995|    2022|       1
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 1890- 1912 (29.36/11.18)	LS.NMLQRRS...GAM..L.......QPPSLH......AVTS
 1926- 1953 (39.12/17.96)	QQ.QQQQQQQ...QQQ..R.......LLRQAQTRPF.QQGQP
 1976- 1994 (26.94/ 9.50)	LQ.Q.AQTMP...QGY..T.......M...YGTQ.M.P....
 1995- 2022 (50.80/26.06)	LQ.QAAQQQP...GGV..V.......LSPSYNSRAY.PAAHS
 2030- 2055 (40.43/18.87)	LR.Q.LQQQP...SGY..V.......QQQA.SPYLQ.PVAGS
 2059- 2086 (25.31/ 8.37)	NH.QALQQSPlvgGGIdaV.......LTP.....AH.PNLPS
 2108- 2126 (27.64/ 9.99)	LQmQQPQQAP.................QPQ.....Q.PSQTQ
 2147- 2181 (24.16/ 7.57)	LQ.QTQQQQQ...TAA..LvrqlqkqLSSNQPQQGVtPCAH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     181.49|      35|      44|     927|     961|       2
---------------------------------------------------------------------------
  927-  959 (51.63/29.50)	......................SCL..ILNPDQTAQVFEGLCGVVKHV..V..NPS....ECSSP
  960- 1006 (35.16/17.66)	ER.........cilaylydlyvSCS..HLRS.KFGDLFSSACSKVKQT..IynNVM....PANSN
 1007- 1062 (31.31/14.89)	LRwdpdfmmdfienpsarsinySMLgkILN.DNAANRYSFVCNTLMNV..C..MGH....QDAGR
 1077- 1109 (35.19/17.68)	.......................CT..VLSSEWLG.VLKALCCSSNHVwgF..NDV....LCTVD
 1110- 1154 (28.20/12.65)	VS...............dlsfhDSLatFIAILIARQCF.SLEDVVQHV..A..LPSllaaACGDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     572.67|     152|     157|    1566|    1720|       3
---------------------------------------------------------------------------
 1421- 1545 (159.84/102.44)	........................TIGSVDPSSTRQngikTFLSSSERRGVWLVAPLIARLPTSVQG..RV...LKAAGEELEK..GQHLGSSS....KKERDRQKQ........KSMSLLSQQPFLS.LVLT...CLKGQD..EQREGLLTSLQNQVnqilSNWR.EERYQDDT
 1566- 1720 (241.53/170.21)	FDTVQ..RSTQGTTDWALLLLQiiTSGTVDMHTNNE....LFTTVLDMLGVLINGTLASDLSSASPGGSEE...NKRAYMNLVKKLKKELGDKR....SESIDKVRQ..LLPLPKQTCDVITCEPMGS.LIDTKGNKIAGFDSIDKKQGLQVSTKQKV....SPWDlFEGQKNPA
 1727- 1860 (171.30/110.77)	FGTVRvdRKVIKYEEQQHFLLY....HTHTMPKPRS....YYLEPLPLPPEEEEEELTSPVSQEPERKSAElsdQGKATADEEKKTK...GRKRktksSSRIDEYQQtnLYRVPPNYS......PMSSqMTHHPQPALWGYNLVSQPQ..QPS......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.23|      33|     202|     469|     501|       4
---------------------------------------------------------------------------
  469-  501 (61.43/34.93)	HCFDRTDSSN..SMETLYHKIFWANQNKDNQEVAP
  672-  706 (56.79/31.75)	HIFDDVDKSDfkSDPASEFPIFSPMPGESCENINP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.59|      16|     542|     789|     828|       9
---------------------------------------------------------------------------
  767-  782 (27.44/20.56)	GVGKERDEARHQLKKI
  799-  814 (27.15/25.96)	GVGDEGQKARKTKQEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.16|      30|     157|     550|     603|      18
---------------------------------------------------------------------------
  554-  584 (46.82/57.21)	ESISS.ASLAGSSLPVFQNVLLRFlDTQAPAL
  846-  876 (50.34/15.05)	EQITSfASGTSYHLPLAHHIQLIF.DLMEPAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04091 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LQMKLLQQQQQQQQQQQQQQQRLLRQAQTRPFQQGQPGDQAALFTAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQAAQQQPGGVVLSPSYNSRAYPAAHSSPALMERLRQLQQQPSGYVQQQASPYLQPVAGSQRLNHQALQQSPLVGGGIDAVLTPAHPNLPSVPLPQDPMRPRQQQVRQQQRLLQMQQPQQAPQPQQPSQTQSQALGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPCAHPSHF
2) QPSFFLQNPSLNPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMLQPPSLHAV
3) RSYYLEPLPLPPEEEEEELTSPVSQEPERKSAELSDQGKATADEEKKTKGRKRKTKSSSRIDEYQQTNLYRVPPNYSPMSSQMTHHPQPALWGYNLV
1917
1858
1757
2185
1910
1853










Molecular Recognition Features






MoRF SequenceStartStop




NANANA