<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04089

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTSSKMPMMLDDHMGPLGAAMPNMDDDLFGDEVLPMATRPPSKQLQQRVDEMRSRGCCRSISCSKLGTIASISPDGTHINLQCSRANPSDVSWELSEPTPCSIFSPTLPGGPIVHLAWAPAMHPELAVIDAYGRTGKLFIPPEITPLRVPNQVQFNVTYGPAVRENGKYQYNNNIIQASGPWHPNPSKSALVCVTANGLLKLFYPQNSNLVQETQLEMESITSSDDLITHAAMCSDRGKLVVILATAARQLKVLHAEINWGTSQPQDKQIPPGSLPLKPSLKAEHITGTSWLQQGLVESHLDASMDQISCLEVYAPVLDMKTKSSLPATILVVRSHVPPAQTPYNVEYQSIIDRWDILTDQPQHLHPAFEQRGSKTGSASALHPMTRLRKRESIVINKIIISIETTQLGRVICIGFSDGTIQLRDRSTMAEMANEDHHNLIMVPQQAGFQFDDEKPCVQMAISPNNCSFTQVCENGKLRWNSLKYPVDQIGSTRQDPQYDAVLAGLTLAAANAAHQASNYDDVLAVARPFVEKHPRFLHDLVSTLVFMLNINVDYSEDLHHDALIRNLQIQTVFGLLNHLGFRGEFKPRSFISKFAMLGLNIRHIVILITLASNSSMNPAKEKWTPLDEPEVVDALTGCAKWALDLLCWLTDSLFVLRDDPKFMELLNPGRFSEMTAYLKSKNDISLHFLLCSSTRGFLLAACKRLSHLQAVSAQATQYWDKNAATHNSTDSHANQGIIAVQQAYLKMQRCITTALIKVKEIERLLNILGAEIKQAYQASLAILAQKQQQQSGKPNQPPPDTAIKKAQAHCELNMLLAENPPPQFLAVIKKLFEVDLKNLMASTDRSGLFFTDFELLEVEEDPRRLAARKAQGKYVDTFKRVELTAYNPPKASEGDKAY
Length899
PositionTail
OrganismDiaporthe ampelina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Diaporthaceae> Diaporthe.
Aromaticity0.07
Grand average of hydropathy-0.231
Instability index42.07
Isoelectric point6.54
Molecular weight99869.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04089
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.16|      22|      22|     797|     818|       1
---------------------------------------------------------------------------
  797-  818 (40.23/24.16)	QPPPD.TAIKKAQAHCELNMLLA
  820-  842 (33.94/19.28)	NPPPQfLAVIKKLFEVDLKNLMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.54|      11|      18|     494|     504|       2
---------------------------------------------------------------------------
  494-  504 (20.91/12.11)	RQDPQYDAVLA
  515-  525 (20.63/11.86)	HQASNYDDVLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.86|      10|     128|     140|     150|       4
---------------------------------------------------------------------------
  140-  149 (19.39/10.95)	IPPEITPLRV
  337-  346 (20.47/ 6.22)	VPPAQTPYNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.63|      17|      24|     251|     267|       5
---------------------------------------------------------------------------
  251-  267 (32.76/19.59)	LK.VLHAEINWGTSQPQD
  277-  294 (26.87/14.91)	LKpSLKAEHITGTSWLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.41|      10|      17|      56|      65|       7
---------------------------------------------------------------------------
   56-   65 (20.38/14.21)	GCCRSISCSK
   76-   85 (19.03/12.72)	GTHINLQCSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04089 with Med16 domain of Kingdom Fungi
Unable to open file!