<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04085

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGDSGGTNAASRHEQAATSRREWQRFLQRCLFQRLDFDKFAEYAPLLHARHPLGHGPVADLVLRPTSWNKYTLDPRVPHYMQTLLDLGLVDTPAILAALYRYSTCHVLLAADPHLKREDGEADGGGDKPAQAPGKNEVTRWQSSFSSEEVIFYRLTKAVAQGLAIKNSRDALDVSVVMARWMTLFTAASAVFQADDDDVIMGGAGSKASQQRRDDMDNSRAAFVMLLLGVCENPVLLQALGKPFAKGARKALSQSLASFIPSIMQNASQIAARLELFRTETLAGFEPIDKKKEAANAEMDELLDETLGLQNLSIPDLHVDRSRAGLYIYLNAALVGRPLIDDAAFYNYLHNRYQGDIQLTAIDLILASFDVLANAIFKNEGQKTANLIRSYLINKVPLILASFATPEPMYPFNSELCITNALIRVDTNTFPTLTSLFENNLSSNPFTESVRSDFVTACCLHGLVPETSIDKLIGDYTYQTLPAGGRYNKDKLVQECLADPLQERIQKLVTELESMDGNVGACCQALTEMLGKLCSNKETMSLKTLCCKLVGKPLNLDVLLLFDKPTTILSPLCELLDNWRYEDDQGEYQPVYEEFGSVLLLLLAFVYRYNLSASDLGIRSADSFVAKLLANGQLSRPLDELNDQEKNQLNGWIHGLFDTDGGGLADDLLSSCPPQDLYLLIPTLFHNIVLAFSTGNLTEETLKTGIEYLVEPFLGPSLVTGIMYLSNCLWTDRPEENRATVKILQLIIRPSQKMSPESSDMLNTVKNIVAKPLESGLRTYQRQNPRSQDVEPLLQVLKGNVELSRRTGAAGDKELEQWTSSGSGGLTSSIRNTFQNLTMWSLNPGVMPTAYAHRQILVGLKLMGARRLLQAILQELKQLTETGNGSIAYDVAIALVCAPDASSVATDALAPTPQQRRLSLREALKWEAEEWKKIQKKDPAMAETVVRLYQKVEAQMTPTATMATLPHGAEAAMANALVDDAAAVTAAASQLGMDDPMALDAGAAAGLSLDLGGGGGDLNLGGSGADSAGGLDLTGGDDMFSALGPLDGWDSMDLT
Length1055
PositionTail
OrganismDiaporthe ampelina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Diaporthaceae> Diaporthe.
Aromaticity0.07
Grand average of hydropathy-0.126
Instability index42.24
Isoelectric point4.94
Molecular weight115162.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04085
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.47|      18|      19|     997|    1014|       1
---------------------------------------------------------------------------
  997- 1014 (32.18/15.29)	MAL.DAGAAAGLSLDLGGG
 1018- 1036 (27.29/11.89)	LNLgGSGADSAGGLDLTGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.66|      23|      25|     522|     546|       2
---------------------------------------------------------------------------
  522-  544 (41.01/23.61)	CCQALTEMLG...KLCSNKETMSLKT
  546-  571 (32.65/24.61)	CCKLVGKPLNldvLLLFDKPTTILSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.53|      19|      26|     639|     657|       4
---------------------------------------------------------------------------
  639-  657 (35.14/20.10)	DELNDQEKNQLNGWIHGLF
  667-  685 (34.39/19.52)	DLLSSCPPQDLYLLIPTLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.62|      25|      33|     365|     397|       6
---------------------------------------------------------------------------
  365-  389 (42.21/40.16)	ILASFDVLANAI.FKNEGQKTANLIR
  399-  424 (41.41/21.01)	ILASFATPEPMYpFNSELCITNALIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.29|      15|      15|     942|     956|      10
---------------------------------------------------------------------------
  942-  956 (24.50/22.63)	AETVVRLYQKVEAQM
  959-  973 (25.79/24.35)	TATMATLPHGAEAAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.33|      19|      26|     742|     760|      11
---------------------------------------------------------------------------
  742-  760 (32.56/21.10)	KILQLIIRPSQKMSPESSD
  771-  789 (33.77/22.16)	KPLESGLRTYQRQNPRSQD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04085 with Med5 domain of Kingdom Fungi
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