Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MTRLRLVQLCNGLERFKADIYRSNPLPNPQNLQNSARILKQNMTHLLEIIQQHSSTFQRVVVYPSTNYPGRTQEGVVMQLLRKKLEPDVETLVEAAREAALAAGIDPKTSFNSTEDSQERKESKKRAKLEAEMQGFGGNDDEDDEDDEDEDDSEEGDPEPHGIGDVWFDSRAWCKTRLAEFVRDDYQDAYTAEERAMGIENVRTGLRQNLEDEYEDDDEDEDEEETEGDLTMTDASSTFPGSDPSSAQLGGMGPGQQVNTAAPSLGEDPERMLWFAARGDRDLPPGIELESQRVEKHGQKRRFGDR |
Length | 306 |
Position | Head |
Organism | Diaporthe ampelina |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Diaporthaceae> Diaporthe. |
Aromaticity | 0.06 |
Grand average of hydropathy | -1.046 |
Instability index | 48.82 |
Isoelectric point | 4.41 |
Molecular weight | 34560.21 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04082 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 141.18| 43| 69| 115| 157| 1 --------------------------------------------------------------------------- 115- 157 (76.81/32.60) EDSQERKESKKRA.KLEAEMQGFGGN.DDEDDEDDEDEDDSE.EGD 184- 229 (64.37/26.39) DDYQDAYTAEERAmGIENVRTGLRQNlEDEYEDDDEDEDEEEtEGD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KLEAEM 2) PSLGEDPERMLWFAARGDRDLPPGIELESQRVEKHGQKRRFGDR | 128 263 | 133 306 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab