<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04074

Description Putative transcription mediator subunit med12
SequenceMGVPQRQPPSRSLSGSSTLSQRPAHQRTLSSQYIPSSPIRNNNNNSTNSNSSISADFAADASSQNSNATQTQYGTPRRGGSRLRLELSNQGIAHSGFIESPTSAGPLDPFKSFASSRPAAPSMSGDVSDLGDMSSPQTSRGAPTVDNDNNPLPMPRRRTRFVVPDARKDVAAPAPAPVKKDIRPKPYTVEVPSAAPRYLVLNSSGKADSSSRIGATNAPPTAHADFNPWTGDGPEDHFTQTFIQTGFFDKAPVAQVETSSAKGLIFPSLKHKSGLYALSTVFTGILGSRRHNGQINSASTFKPPPRVTVTDTKREGWLRDLANPTTSLRRLSRTIPHGIRGKGLLEQCLNKNIPTDRAVWLAKCVGANEVRAFKRKGVNGAVVMGGEAKWVRDWTMFVEQFVDGVVSAFEDAEWKTKVNYA
Length421
PositionKinase
OrganismDiaporthe ampelina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Diaporthaceae> Diaporthe.
Aromaticity0.07
Grand average of hydropathy-0.586
Instability index48.29
Isoelectric point10.12
Molecular weight45411.24
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04074
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     191.15|      42|      74|     109|     151|       1
---------------------------------------------------------------------------
   46-   71 (24.59/ 7.07)	.......STN.SNSS.ISADFA..ADASS.QNSNAT.QT.......
   73-  106 (41.65/16.62)	....YGTPRR.GGSR.LRLELSNQGIAHSGFIE..S.PTSAGP...
  109-  151 (68.93/35.87)	PfKSFASSRP.AAPS.MSGDVSDLGDMSSPQTSRGA.PTVDNDNNP
  184-  228 (55.99/24.86)	P.KPYTVEVPsAAPRyLVLNSSGKADSSSRIGATNApPTAHADFNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.52|      17|     148|     153|     173|       2
---------------------------------------------------------------------------
  153-  173 (27.59/22.76)	PMPrrrtRFVVPDAR.....KDVAAP
  303-  324 (26.92/12.90)	PPP....RVTVTDTKregwlRDLANP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.89|      10|      14|       5|      14|       3
---------------------------------------------------------------------------
    5-   14 (18.97/ 9.72)	QRQPPSRSLS
   21-   30 (18.91/ 9.66)	QRPAHQRTLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04074 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GKADSSSRIGATNAPPTAHADFNPWTGDGPE
2) MGVPQRQPPSRSLSGSSTLSQRPAHQRTLSSQYIPSSPIRNNNNNSTNSNSSISADFAADASSQNSNATQTQYGTPRRGGSRLRLELSNQGIAHSGFIESPTSAGPLDPFKSFASSRPAAPSMSGDVSDLGDMSSPQTSRGAPTVDNDNNPLPMPRRRTRFVVPDARKDVAAPAPAPVKKDIRPKPY
205
1
235
187










Molecular Recognition Features






MoRF SequenceStartStop




1) KKDIRPKPYTV
2) RRRTRFVVPDARKDVAAP
179
156
189
173