<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04069

Description Uncharacterized protein
SequenceMTSRTPIGVHPRPPQRTLSSTTLPPVQRPPPQRALSQQLFPSSPVRKDSALSDASSDSFDPVQAHGQGQVQGANLAQGHGRLVTTPRRVGSRLRLELSNIDAPGSVASASMSASASASVSAASSPQSHTTSRGPSMADAVDVDGSSPAPSRASAADFDNDNHPLPMPRRRPPTSQTYPELSRRLAAPPRATPALKKDGRPRPWTVEVPKNAPRYPSADKKPNPAGGDPFSRGLFSGHADFFPWHGGNGKHHEDDWSPEAIQKGTWDRGNQNETSTARMTISPAIKQKTGLSALSTIFMGVLNQRRHRGHVTAPSTFKPPPRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGAFAIAGEFKWIRDWTVFVEQFVESVASAFGEPDWKAKLTYAIRLATNLYAEQLLDRDHYLDWITSGLEHSPQSKIPMWILIAQICWADILRSRKYGRRLVYSLLAHLNTIHISPDKDILMQLSSQLSSLLSSLLRNNPDSFIDPALWPKYRDALDAFLPRDDKVGREAYHYINIRNGQLSFTSTASPLAGRPQLVRLLDATLLSQIHRDLPQKCWATGDDKVDIVRTTVDWATSFYRPGLARVYIAANLIRFWSTLRVNVTGAILEHMDTIPAGDGGRKQTVYQLVTELVRTGQFSVPQYLKWLMARGACSHPSEVDSDDAPCTTRLLVHLPLRYLTEEQKDDRANLLRRAANYSTAEEASDIGNALMCVNHTLGLPVQGDAMAGRNPIPLRKLLPRIISSSKALQTAVGLHLRETVLRLVKAVQPVSLRLFSAIRTILEGTQDFYALCDVLKLCSRTTNIEVLASCVDTVNLNLQVFYAQGGAERLFNIFFERLKAINQEQGLVSRPLLASLCFLSRRMPSRQEISKYLAHELVQSDRNNATDACSPISDNMVNPPSGADGEVSEQIEKLLASGNSIDHPTMNRLFGYIIRRLEAGWAKMDDNRRIHASLLTRLRLFDSQHFDKLMSDWVGRVRLLKSRKRLDAVFPLLIITDALPVSFLVGPASLTRAAAPGEADAAALPDLATPGAVTYLQELLHLILSKLPADTDLSQEEAYRFGIYQRAIQFNHYKGLLSLIRHAVVEYADLRARDGNANLLLDDGTYRERVLDALRLLIVVHTADVTEVFSAKTIPPAGFRLVHEIIGSLFQQEGDQGTSSAAPYDQILLLANELTMPFCQIKLNMDLSIPAPRQTDGEDGQQQHASQFDLFAKAMDRAIEAQNIMWTTMLPCLSEDISRHLQSQARSRFLDLVPTSSSSSKDPSVLHDTLANSNNLYLAEKLLGVIEAIVVGQQPPNTAQLTSVLADRLSDLVEVVVAPKDQEGKMKGLLIPIIEHWLPMLLKFVLLHSVSLEPLSASVMTTTAQGKLVLPPHHEARAHTVLTLCRLFLALEALPSQIAGPSLLQQVFDVTTVLADGLPDDLRLHCAKSILLLPGMMPNLHSSSDARLFYIFSVPQLTATDGLMLAHREKTTMPHSTAARGMGAMYGIGPTTQERLSPFVLRRWELLSEPTPNVGVNDTSLSLGLFEAIRIH
Length1585
PositionKinase
OrganismTrichoderma harzianum (Hypocrea lixii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.204
Instability index47.18
Isoelectric point8.97
Molecular weight174970.24
Publications
PubMed=26067977

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04069
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     432.31|     129|     144|      24|     167|       1
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   10-   88 (87.28/47.64)	............................................................HPRP.PqrtlssttlPPVQRPPPQRALSQQLfPSSPVRKDSAL.SD..........................ASSDSFDPVQAHGQGQVQG.AN.LAQGHGRLVTTPRR
  102-  245 (152.13/106.71)	APGSVASASMSASASASVSAASSPQSHTTSRGPSMADAVDVDGSSPAPSRASAADFDNDNHPLPmP......rrrPPTSQTYPE..LSRRL..AAPPRATPALkKDgrprpwtvevpknaprypsadkkpnpAGGDPF......SRGLFSGhAD.FFPWHG........
  246-  373 (192.89/108.07)	GNGKHHEDDWSPEAIQKGTWDRGNQNETSTARMTISPAIKQKTGLSALSTIFMGVLNQRRH........rghvtaPSTFKPPPRVTLTDT..KREVWMKDLAN.PA..........................ISLRRLSRTIPHG...IRG.RTlLDQCLNKSVPTERA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     181.03|      65|     203|    1229|    1307|       2
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  884-  931 (53.98/25.94)	..........................FNIFFERLKAINQEQGLVSRPLLASLCF.LSRRMPSrQEISKYLahELV
 1093- 1122 (27.05/ 9.48)	LHLILSkLPA....D.TDLSQEEAYRFGIYQRAIQ........................................
 1236- 1306 (100.00/85.93)	LNMDLS.IPAprqtDgEDGQQQHASQFDLFAKAMDRAIEAQNIMWTTMLPCLSEdISRHLQS.QARSRFL..DLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.88|      35|     138|    1042|    1090|       3
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 1045- 1080 (54.15/59.80)	LLIITDALPvSFLVGPASLTRAAAPGEADAAALP.DL
 1440- 1475 (54.73/24.48)	LFLALEALP.SQIAGPSLLQQVFDVTTVLADGLPdDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.77|      55|     127|     573|     629|       4
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  445-  487 (46.99/20.75)	.......YAEQLLDR..............DHYLDWITSGLEHSPQSKIP.mwiliaQICWA......DILR.......
  573-  629 (93.02/52.87)	GQLSFTSTASPLAGR..............PQLVRLLDATLLSQIHRDLP.......QKCWAtgDDKVDIVRTTVDWAT
  689-  752 (61.77/29.43)	GQFSVPQYLKWLMARgacshpsevdsddaPCTTRLL.......VH..LPlrylteeQK.....DDRANLLRRAANYST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.53|      22|     204|     201|     222|       7
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  201-  222 (42.65/26.71)	RPWTVEVPKNAPRYPSADKKPN
  408-  429 (39.88/24.48)	RDWTVFVEQFVESVASAFGEPD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04069 with Med12 domain of Kingdom Fungi
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