<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04066

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLCMDSPDRAPASQSPPRAGSSTLRTPWRRLSPHSSPAQPSVPPFARDKRRRGFVSTTANCAVTGCHEPIILQAVDMDTGEYETNTLLINNVSSIAYRLYEPSSNLSQNFASVALEIENSLREKGHIVLYDATKKALWHFQFLPKDENSDDLGDSLELPPDVTGHGLALREHGVIEPPIIQKPRPQGLQSSGTPTSLLSTASALEQAHRPTLSSPLQTTAPITQDPDPKAEKSKTTSTAQRALYEKFIASVLLTISTTFCRRVGAVPLNYRTVILSPTAYDAQPHGVAIGRPQILGTFRAYLTTTGALMISLALTKCRGILSLDDTVPSSLAPSGYSVLAAPFGIMTATQNFVPGDGGLTSLAQTPMTQFFNFRGGLDGQESLWKQACLRFLNFRGIAASTLGGCLWVNLLVPKPKNPDTRGDQRSSSASSSFTLPWPRRLCFRKKNVDASSTSRVVDTVLSGHEESHDPLGNAKGWHASITEREEKAKRALERAANLPKDPQPQSAESKTTPKPSGLSPVALQRPNTATAGIMYPTPPDGVHQPNGVTPSIDGTLSSPGNPLSAPVIAEADAVVQNEPTGGDSVDQSPEFADSKRHRSDSNVLGDGETVFGGEIGGDMFDDNDITEADFNFFDEKPDDMDADLPMADLSSSEMALPPPPQALEETVIPAETTSLPLAPTPTSLPLHPPAAPSAPTPAQAATPAPAPAPIPSLPPPTSTPLLPPPLPPPQSERVVFAKPELKHARSQNEDPARRSRGEIRVTPAKRESSPFDPHAVFKRVKASLKMPKYDSTSASQPTLRKAKIFESLDFDPALPMINKKYEQGGLFDLSALSKVEKMERPSIDLRAVPETDYLKRHGKLSKRQKDRPITRNTMAKQYSALEPQMSTTSPMKLDGSISGEDSSAESDQDDSSYTSDEPGSPHKASIRILNADDDILSQITSLRDCDIEEPDHQLAMELPRLSKSDMTGVPLSALFSDPEPLLLDMALNDDDLIQIAQIVTEQAATGGLDIFRASDFEAPTLSASQKRQELLTHSRDAFHTLEDIIAQFFGDTMPMRLKGLLDIQDIPLLSQFQPRQMPGREGNPEAMRPSNLYQIPSPHLEVQRADTKLSVLPSAVSFWESLGLSPSSGSKNINAICVYPGWPGMGDNVQTFLDRIKSVYEFLKLGTFEVMPLGADMEPGLLPYEIDRITTSPDATVTGHGSAMIESMEVLRGIFTNLAITETNFVIYFVYSPDNPGTIIESCTAFQRFFETYQKILATRKEPPQNELVLQLVSADLLSSPSALVVTPTSDLVRLCIETYDRCTLFGGPMPAPAIRLEQLLPRIIDFKLTTNPSASLIRENSCIHVAYAQSVDERWITAAWTDDRGNQQATASYCMGRKGKQPSRNMNEIANEIWETTLELISAWKVLWRVIITKCGPMPQHEMDFWVDLARTEINAKVTVALLTVDTNPSLQLLPPVVKLAPPSAALHTPASTPLPSAFSPEPPTPATPAREGMAVATPSGDGGASNAGAADADLDAILTDVTDQTWGAIAGHRLSNSTSILEVHPALISGYLIKRTGIKVEDAPIVMEVNLVYTEAMPRVHEPLFREMLGYFRGLGTLARARGVVDREADVRPWHIAAAEKAARALYLLM
Length1632
PositionKinase
OrganismTrichoderma harzianum (Hypocrea lixii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.316
Instability index51.82
Isoelectric point5.31
Molecular weight177222.73
Publications
PubMed=26067977

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04066
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.23|      18|      20|     358|     375|       1
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  335-  354 (23.05/12.69)	GYSVLA.APfgiMTATQNFVP
  358-  375 (35.63/24.28)	GLTSLAQTP...MTQFFNFRG
  379-  396 (32.55/21.44)	GQESLWKQA...CLRFLNFRG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     713.66|     207|     765|     486|     739|       2
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  211-  483 (195.95/76.55)	TLSSPLQTTAPITQDPDPKA.EKSKTTStaqralyekfiasvlltisttfcRRVG..AVPL...NYRTV.ILSPTAYDA..QPHGVAigrPQILGTfrayLTTT...GALMISLALTKCRGILSLDDTVPSSLAPS.....................gysvlaapfgimtatqnfvpGDG.................gltslaqtpmtqffnfrggldgqeslwkqaclrflnfrgIAASTLggclwvNLLVPKPKNPDtrGDQRSS..SASSS.FTLPW.....PRRlCFRKKNVDASSTS.RVVDTVLSghEESHDPLG.NAKGWHASITE
  487-  703 (336.61/179.56)	KAKRALERAANLPKDPQPQS.AESKTTP.......................KPSGLSPVALqrpNTATAgIMYPTPPDGvHQPNGVT...PSIDGT....LSSP...GNPLSAPVIAEADAVVQNEPTGGDSVDQSPEF.ADSKRHRS....DSNVL....................GDGETVFGGEIggdmfDDND.......................................ITEADF......NFFDEKPDDMD..ADLPMA..DLSSSEMALPP.....PPQ.ALEETVIPAETTSLPLAPTPTS..LPLHPPAAPSAPTPAQAATP
  752-  921 (181.11/105.51)	................ARRSrGEIRVTP.......................AKRESSP......................FDPHAVF...KRVKAS....LKMPkydSTSASQPTLRKAKIF........ESLDFDPALpMINKKYEQgglfDLSAL....................SKVEKMERPSI.....DLRA.......................................VPETDY......LKRHGKLSKRQ..KDRPITrnTMAKQYSALEPqmsttSPM.KLDGS.ISGEDSSAESDQDDSS..YTSDEPGSP...........
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.33|      71|     106|    1005|    1109|       3
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 1012- 1086 (111.42/98.32)	RASDF.EAPTLSASQKRQEL.LTHSRDAFHTLEDIIaQFFGDTMP.....MRLkGLLDIqdIPLLSQFQPRQMP...GR.EGNPEA
 1114- 1195 (101.91/38.30)	SAVSFwESLGLSPSSGSKNInAICVYPGWPGMGDNV.QTFLDRIKsvyefLKL.GTFEV..MPLGADMEPGLLPyeiDRiTTSPDA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.78|      23|     107|    1308|    1330|       4
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 1308- 1330 (41.87/30.08)	GPMPAPAIRLEQLLPRI.IDFKLT
 1417- 1440 (39.90/28.22)	GPMPQHEMDFWVDLARTeINAKVT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.01|      44|    1291|     158|     205|       5
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  161-  204 (75.76/41.67)	DVTGHGLALREHGVIEPP...IIQKPRPQGLQSSGTPTS.LLSTASAL
  934-  981 (67.25/26.25)	DILSQITSLRDCDIEEPDhqlAMELPRLSKSDMTGVPLSaLFSDPEPL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.47|      29|     764|     705|     739|       7
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  705-  739 (54.26/30.12)	PAPAPIPSLPPPtstpllPPPLP.PPQSERVVFAKP
 1471- 1500 (52.20/19.80)	PASTPLPSAFSP......EPPTPaTPAREGMAVATP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04066 with Med13 domain of Kingdom Fungi
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