<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04060

Description CMGC/CDK/CDK8 protein kinase
SequenceMPLRLRPGYPHSSSSHHLFASSSSSSSSAHRLYTDGRDQSAGYQPKARVTERYRIIGFISSGTYGRVYKAVSRASNGEGIAVVRTSSGLTPTSGSGQAPIEVAIKKFKPDKEGEQVSYTGISQSAIREMSLCSELRHSNVIRLVEIILEDKCIFMVFEYAEHDLLQIIHHHTQQPRHPIPPATVKSIMFQLLNGCQYLHTNWVLHRDLKPANIMVTSGGEVKIGDLGLARRFDKPLHSLFSGDKVVVTIWYRAPELILGSYHYTPAIDMWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMHKIAEIMGMPTKERWPLLPAMPEYIQLNTLSAMQHSTHSHHHHHHQNPPSRGYATTSSLEKWYYSTINNNSGAGSAASGPNGQPALQSLGAEGYKLLAGLLEYDPEKRLTAAQALQSVFFSSGDRVSANCFEGVKVEYPHRRVSQDDNDIRTSSLPGTKRSGLPDDTLLRPAKRMKE
Length483
PositionKinase
OrganismTrichoderma harzianum (Hypocrea lixii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.08
Grand average of hydropathy-0.432
Instability index46.24
Isoelectric point9.26
Molecular weight53769.50
Publications
PubMed=26067977

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04060
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.87|      14|     176|     169|     187|       1
---------------------------------------------------------------------------
  169-  187 (23.28/23.75)	HHHTQQprhpiPP....ATVKSI
  348-  365 (24.58/11.74)	HHHHQN.....PPsrgyATTSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.15|      17|      32|      26|      42|       3
---------------------------------------------------------------------------
   26-   42 (30.17/19.30)	SSSAH.RLYTDGRDQSAG
   60-   77 (24.98/14.81)	SSGTYgRVYKAVSRASNG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04060 with CDK8 domain of Kingdom Fungi
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