Description | Mediator-RNA polymerase II transcription subunit 21 |
Sequence | MGDRLTQLQDAVDQFAQQLVASLHFVHMRHDLEPLGPKDKIREPKEQVPKEVDALPPQDFRAGLVELARDLIVKEQQIEVLISTLPGLDNSEQDQERHIKDLEEDLKTAEAQRVEALKERDHILKQLDSTIRMIRRP |
Length | 137 |
Position | Middle |
Organism | Trichoderma harzianum (Hypocrea lixii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma. |
Aromaticity | 0.02 |
Grand average of hydropathy | -0.697 |
Instability index | 51.75 |
Isoelectric point | 5.12 |
Molecular weight | 15840.85 |
Publications | PubMed=26067977 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi transcription corepressor activity GO:0003714 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP04056 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 83.15| 28| 33| 47| 79| 1 --------------------------------------------------------------------------- 52- 79 (46.67/29.52) VDALP.....PQDFRAGLVELARDLIVKE.QQIE 82- 115 (36.47/13.57) ISTLPgldnsEQDQERHIKDLEEDLKTAEaQRVE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DQERHIKDLEE 2) GPKDKIREPKEQVPKEVDAL 3) LVELARDLIVKEQ 4) STLPGL | 94 36 64 83 | 104 55 76 88 |
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