Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MADGGDSGNPVKVFTSADRIRQLNEVDKDVTKLIHSAGLAIQALTNAKSADSSTAENSLESHKARFKEATSQYFALLSSIDVRLRRQVYALEEASILAPDPSSSRSADIPASGAGAVGAAANPLDVSWLNSRKDTVGKEKEAELWAAAREFVEEINQSSSRDRSGKLEDGVEEKMEVD |
Length | 178 |
Position | Head |
Organism | Aspergillus rambellii |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.504 |
Instability index | 42.76 |
Isoelectric point | 4.91 |
Molecular weight | 19094.82 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04049 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 57.77| 19| 25| 119| 138| 1 --------------------------------------------------------------------------- 119- 138 (29.89/27.14) AAANPLdVSWLN..SRKDTVGK 146- 166 (27.89/19.24) AAAREF.VEEINqsSSRDRSGK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EDGVEEKMEVD 2) KEKEAELWAAAREFVEEINQS 3) VKVFTSADRIR | 168 138 11 | 178 158 21 |
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