<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04048

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDPFSLPLRPVIEKHDRPDSLPREIAQINAQWGSFRDVSEASLRAHIEEDEDKDPWAGDRDSENAAAEVDTSERRDQLYKRRAEITQFALQAHMEALFALDFVSLLLSKYTPRQAETSMSAFLKSAAPLGTLNSELVNPPPRPEALITDVKSVSRGWRLQNFDAAANKLLKCAARLETEVQAETRYWNGVLAVKEKGWKVCRLPREGQALGVQYGFLEATPIFRDRGLAALRRTDDGNLVLDKGLMPQKAQAVRVRVKSRGRVTGCSKAYRPTKQAESIERRILQARDTLFEEELFHELVREARILGSQGVTTRQNLVQLPVSEEQEILLDLVDGEDMTSNEDASDSSEHDVLADVLAHSIRILLSYSHRQNHRRRTQPPPPISKNRRPAPEYHILRPIIAYLQHDSHVRWLESFMKDIHGVLNSAGLKCEFHATPFASIGTLQPNKSVPTVEALVRVFLTPFESTFSGNLVTPQSFFKVQVRTNPAVPPFGTHYDISINLPQNPDVQPPTRIGLQDEVAAVITHFIMLDITSAIALQSPQIGQDILNSHQESASKVSWEVAYPHHGELLAVTSTGQSKKMKVSLSRQELALQIYSSGRADGINQPIAAKSPTLQSQTWKPNLGGSHPSVMDFVARVSQI
Length641
PositionHead
OrganismAspergillus rambellii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.414
Instability index54.82
Isoelectric point6.70
Molecular weight71633.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04048
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.19|      24|      27|     172|     198|       2
---------------------------------------------------------------------------
  125-  152 (32.23/12.50)	KSAAPLGTlnsElVNPPPRPEALITDVK
  172-  195 (43.96/21.60)	KCAARLET...E.VQAETRYWNGVLAVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.51|      22|      28|     494|     518|       3
---------------------------------------------------------------------------
  494-  518 (29.88/33.18)	THYdISINLPQNPDVQPPtRIGlQD
  525-  546 (39.63/25.89)	THF.IMLDITSAIALQSP.QIG.QD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.09|      15|      27|     244|     258|       4
---------------------------------------------------------------------------
  244-  258 (25.25/18.77)	KGLMPQK.AQAVRVRV
  269-  284 (20.84/14.08)	KAYRPTKqAESIERRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.02|      17|      38|     360|     376|       5
---------------------------------------------------------------------------
  360-  376 (30.47/19.32)	HSIRILLSYSHRQNHRR
  395-  411 (30.54/19.38)	HILRPIIAYLQHDSHVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.30|      12|      38|       9|      20|       6
---------------------------------------------------------------------------
    9-   20 (22.47/15.88)	LRPVIEKHDRPD
   44-   55 (20.83/14.18)	LRAHIEEDEDKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04048 with Med17 domain of Kingdom Fungi
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