<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04047

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGSAEQWGIFLHRCLIDRVDAGEFRDLTKLLSQRFPITEWALIDTLLETRLFTRIKWDPLVPLYVDCLCKMGKVQISTALTSLLKFSSIHDKPQSPGADANQLKKNSKCYTLMTDIRVIQDAMLSVSTGSATKTLTEAIHTFSAAVDWIQAVVSWHNNHIDPSQQTGGLMSSTDAVLLFESLGILLAALSGTAKGLEVLSADSHEALKIQLGQALSAYLPLCVEVSLPLRNRLDSLQKEFSLYGQPQSKSLEVSMMDNVHVNALQFEASVIDGPVISSRAGLYVYINSMLFGRPLVDDSILLSYLTNRYGGHYEVLIEEVITASFDVLSNAMYRNESGRTMFLFRSFLVNKLPTFFAAMLTVSMVSLPMEVCISHALSRLDPNAFPSFSQMFSMQGNTVLSDVRQEFLFSCASHKLIPESSIERLLGENPMQTLPVGGPYIKDDLVSQITSNPERAEQLISDIESTEGNASAIVGAITEVMHNLCNQRETMTLKNICNSLSRRPQSLDVILLFRSPKQVLQPLCALLDSWHWDEDQGESQPVYDEFGSILLLVLTFKYRYDLRPFDLGITSENSFVLRLIERGSCCQKLDELNEKQNKNLGEWIAALFIAEGISEETMSACSPQEFYMLVSTLFNQSLGACEAGKLEFDTLKGGFEYLLEPFLLPSLVFALTWLGNHIWESEQDPTIPLKTLQSLVNPSSISGEAREIHLTVLNITARSLEEQLKDVRARHPSRMDIKPILDALEPCLSFQRTGSCRRSELESWTTHSPGGLLGSIRSTFQSLVLWSTSPDVSMAPLSYTHRQVVAGIRMLGAPRVFNSLLEELKLQSEAGSGDLALDVAATIVCAPLAESFAVEQNNHHPVDPTKEPVPRTPILTLRDALNLQHENVPKMSEKDPLRAEVIVRLYRRVNSLMTPPAQVTNLDMSNIIQNMQLGVDTPAPMGLHTSGADGTGAQHATANINQIMDNAAAAVGMDSGQGMAGMAGMEGMGLDTSDEGLDPSIDDVLNAADMNPEFLDLDMEGMFQ
Length1024
PositionTail
OrganismAspergillus rambellii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.032
Instability index47.84
Isoelectric point4.89
Molecular weight113015.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04047
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     249.35|      72|     233|     453|     551|       2
---------------------------------------------------------------------------
  453-  530 (107.88/86.53)	PERAEQLISDIES.TEGNASAIVGAITEVMhNLCNQRETMTLKNIcnsLSRRPQSLDVILLFRSPKQVLQPLcaLLDSW
  688-  744 (89.67/50.72)	PLKTLQSLVNPSS.ISGEAREI..HLT.VL.NITARSLEEQLKDV...RARHPSRMDI...........KP...ILDAL
  757-  797 (51.79/41.04)	.RR.....SELESwTTHSPGGLLGSIRSTF.......................QSL..VLWSTSPDVSMAPL.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.58|      27|      52|     909|     936|       3
---------------------------------------------------------------------------
  909-  936 (42.15/29.62)	VNSLMTPPAQVTNLDMSNIIQNMQlGVD
  960-  986 (46.43/28.36)	INQIMDNAAAAVGMDSGQGMAGMA.GME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     155.35|      44|      46|     287|     332|       6
---------------------------------------------------------------------------
  242-  284 (36.02/18.55)	...LYGQPQ.SKSLEVSMMDNVHvnALQFEasVIDG.PVISsrAGLYV......
  287-  332 (66.52/48.16)	NsmLFGRPLVDDSILLSYLTNRY..GGHYE..VLIE.EVIT..ASFDV.LSNAM
  337-  377 (52.81/31.57)	S....GRTMF...LFRSFLVNKL..PTFFA..AMLTvSMVS..LPMEVcISHAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04047 with Med5 domain of Kingdom Fungi
Unable to open file!