<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04042

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDGINVDDLFGESASLELALPTTTAPPTTKGLAQRLDEMRLVGCCQKIAWSKLGCIAYISQDSSRVNVRHLQCRPSDGKWVLSDETPLPQVAEAHNGHTIVHLSWNEPGSEIAVVDSSGRVSIYSIPFALNGVNGIRQAAFDPDDDGAQIVGMMWLNQHRSVHSFYQAAKVQGRWAYSPFRRRPIGPFHPANKAALLCVTRSGIMKLLYQNPDARWAEITVELNNTNHSDRLLTHAALVATQAGILIATHSSCQKISLYRVNIQWNPAQWDPAQQKQAPQQFPVPSFRLVHSKVEVPYNIPSANRTAGENQDDQLPFTNSLYCLTSLQIILPASDNSAGSAPNPWIVAVFSIPPHAVLPHQQPQVPSSVIVRWQLDSAALILHPKFDEVTSRKGSLQMKPKTVLRRLDDIISDRHVVSIDQMEYGNVLAICYDDGSVAFYDPKTMTVFNGVDDANTVTSLAQAGFHYPLESSGLHISFSPSACVAVSLDSEGHTHLRVMEHSYGAESGLYDENAQTAFINEVYRALSINCNFTMEQEKLMNHPYIPRALSIQAALGFKSKYKPRNFASVAPWAILQLRQAAILYPFFFQYNKGVQTAEPHDPDVLRMVLGNTKWALDFASYILNELFDLADEFEGLSSDQEAFTQKLKSTTSLPLIILLSSMSRAFLRFICRGLRGIHAGYASAPLTGDARIYYAEICQTLDTCPVRIDVYEKFLASVDSAVRHAYHGAGFGDNERPGPEKELLISSRIPPVLITAVSAILRQTMPALKSDVDRMAIYMGDYSWLGLGSDPRTELYKRSRDVDIIKKIPLRAVSGPSVAEMNQSSKHGNNQGYLRRRCVRCCEISDGTYPPRTVLAFRMIYKLGHLRACICGGMWTLESVSDQ
Length884
PositionTail
OrganismAspergillus rambellii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.09
Grand average of hydropathy-0.179
Instability index42.07
Isoelectric point6.72
Molecular weight98138.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04042
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     478.01|      95|     198|     311|     406|       1
---------------------------------------------------------------------------
  266-  345 (129.18/79.40)	W.......NPAQWDPAQ...QKQAPQ....QF...PVPSFRLV.HSKV.EVPY...NIPSANR..TAGE.............NQD................................DQLP..FTNSLYCLTSLQIILPASDNSAGSAPNP
  346-  443 (144.50/93.80)	WIVAVFSIPPHAVLPHQ...QPQVPSSViVRW...QLDSAALILHPKFDEVTSRKGSLQMKPK..TVLR.............RLD................................DIISdrHVVSIDQMEYGNVLAICYDDGSVAFYDP
  444-  544 (121.36/74.12)	KTMTVFNGVDDANTVTS...LAQAG....FHY...PLESSG..LHISFSPSACVAVSLDSEGH..THLRvmehsygaesglyDEN................................AQTA..FINEVY..RALSINCNFTMEQEKLMNHP
  545-  664 (82.97/48.23)	YIPRALSI..QAALGFKskyKPRNFASV.APWailQLRQAA.ILYPFFFQYN..KGVQTAEPHdpDVLR................mvlgntkwaldfasyilnelfdladefeglssDQEA..FTQKLKSTTSLPLIILLSSMS.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.79|      78|     626|      74|     157|       2
---------------------------------------------------------------------------
   74-  157 (132.28/127.04)	CRPSDGKWVLSD..ETPLPQVAEA..HNGHTiVHLSWNE.PGSEIAVVDSSgRVSiysiPFALNGVNGI.RQA..AFDPD.DDGAQIVG.MMWL
  699-  786 (110.51/86.07)	CQTLDTCPVRIDvyEKFLASVDSAvrHAYHG.AGFGDNErPGPEKELLISS.RIP....PVLITAVSAIlRQTmpALKSDvDRMAIYMGdYSWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.30|      10|      40|     166|     177|       3
---------------------------------------------------------------------------
  166-  177 (16.11/15.23)	FYQAAkvQGRWA
  209-  218 (21.19/12.58)	LYQNP..DARWA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04042 with Med16 domain of Kingdom Fungi
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