<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04037

Description Uncharacterized protein
SequenceMIPHSSAGVQPWGHPLRAVENVSGRIDASQTLGLADLASDKQSMPVLPPQPRHPAVINLTASAGDAQEREPPAKRLRLDASAGSDAKEASPASGSGGEARNNPGSIANPKPASLSWRGRPVWSFQALISEPPNGADPNEEDATLTPQGVRLASPPPFPLMPWRYTPPELSSCNATTSQDLVQVKQVQTTPYRIEVPSAAPVLKGDKVADFSPWTGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLHMLSSVFMAALEKRQTHNMVTAPSSFKPPPRVTLTDNKRELWLRDLANPSVPLRRLSRTIPHGIRGKALLDQCLSKWIPISRAVWLAKCVGANEIRAFKRKGTSGALAMGLEAKWVRDWTTGVQQFLEAVVGTCGSGDWKSKMTYAATLTARLFFERLLDHDQYITWFLASLESASLNVLPVWLLMLGIYWGCVLRYRKRGRRLAEILLEKLRQITQPRKPTSLQPLADRLSSYIKRLVLEHTSSVILPTSWERYKDLIYSCLNMKEQTDRAVFATLAERNSRVQVPKDRPETTQSAQHRVINLFDSIRSSHDISSTATACLTALEDKAALVFKLLEWSASPFRFGLGRVYTAARLLRKWKTFGVDIDSHIISFLGTVQDANQLSMENVYHVISELVRSQNFSISRYLQWLMAKGVANTSGSNNAHILSGDACLLSHLPMSRLPEHVRSLRHTLLFRAGISGSDEEITIEALKNSISRRLPKIFGAEMSNGGLIDASRPNLSWAVKSEVGIWIRSGVAKHYRDSSRKLLGDPLPIRVSALTPEEFYNIRDILESFGDLSILADVIKQATRCDDNVVLASAADTINYHFDAFGVIGATGDLFRGLLESYARLKRMGTLHLDFVFSLIELGLRIPHEMNMVTLLRQDLARMESKSALAAPSPLSDHIPMTLGEVDSSFQDKLDQLLSSGNGMDESTMSTVFGSLTRLLDHGSDASKLSANDICRYLAYVRPFNPKYFDALLLRWVCGLLKSPSQSMMARILPPLIGVGCVTIHGFVNLVNKLLAPEKATPAVFNPTSLRLDLLELLIPRESKYADMVTYRFCLAQQEFLAKHPKTTLDIIRDAIPLIDSQYLETEPVTSRPDLAGCTTALLHTLLSQASDVVAQYCMQKFTVHPAFTSVLEKAVDVLLGFDSSSASHPVSEAEKVILMNNDFSLPFCQLKLQLLFNAGAGDDVKNSIVDVMFKAAVADSRSKNSHWIGLVNLMNQDAARQIRERAESSFFAIPLFDERADDASISTVADYSNSIENAKLYLGIIEKLAYSVPESGVQSVVPILVEKMDHLLQRLIIMQTNFTSFAENRHGISPDQIAQYRLNFERGLAFWFSALLRVTVLHRTAFTAPASLAAKTNNLHEQTRLLVSMFCISLARLPDNILRFFPTANYFPHPVPPEKLRPCPGILLQTHALDVAASLIDSFPDETRQQCARFLREKCPPFLQFQNDPRFLYLLGPMPDATAPNLPIPASLPSPAAGGSTPTPSGSLPSGASNNQAPPMAACSGIPYGTSDGVNCASDRLRLQHRGRIIGPYPVRPWELLEDAAPILGVNDTAVSLKLFDTRSVRA
Length1593
PositionKinase
OrganismAspergillus rambellii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.147
Instability index45.33
Isoelectric point8.71
Molecular weight175994.73
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.06|      12|      15|    1497|    1508|       1
---------------------------------------------------------------------------
 1497- 1508 (23.25/11.66)	SLPSPAAGGSTP
 1513- 1524 (22.81/11.30)	SLPSGASNNQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.33|      13|      75|    1469|    1485|       2
---------------------------------------------------------------------------
 1455- 1467 (27.32/12.95)	QQCARFLREKCP.P
 1472- 1485 (22.01/ 9.48)	QNDPRFLYLLGPmP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.83|      17|      21|      48|      68|       3
---------------------------------------------------------------------------
   48-   68 (27.19/28.10)	PPQPRhpavINLTASAG.DAQE
   71-   88 (26.64/15.21)	PPAKR....LRLDASAGsDAKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.37|      15|      20|     939|     955|       5
---------------------------------------------------------------------------
  939-  955 (20.39/18.01)	LDQLLSSGNgmDESTMS
  961-  975 (26.99/15.65)	LTRLLDHGS..DASKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.01|      19|      20|    1072|    1090|       7
---------------------------------------------------------------------------
 1072- 1090 (34.32/27.77)	DMVTYRFCLAQQEFLAKHP
 1095- 1113 (31.69/24.94)	DIIRDAIPLIDSQYLETEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.84|      19|      21|      91|     109|       8
---------------------------------------------------------------------------
   91-  109 (35.23/18.58)	PASGS..GGEARNNPGSIANP
  111-  131 (30.61/15.18)	PASLSwrGRPVWSFQALISEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.87|      11|      21|     629|     641|       9
---------------------------------------------------------------------------
  629-  641 (15.28/16.98)	HIISFLgtVQDAN
  650-  660 (19.58/12.43)	HVISEL..VRSQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.79|      20|      23|    1137|    1159|      11
---------------------------------------------------------------------------
 1137- 1159 (27.35/28.67)	DVVAQYCMQKFTvHPafTSVLEK
 1162- 1181 (33.44/21.30)	DVLLGFDSSSAS.HP..VSEAEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.12|      17|      19|     248|     266|      12
---------------------------------------------------------------------------
  250-  266 (31.86/27.04)	YAQLKHRSGLHMLS..SVF
  268-  285 (17.02/ 7.82)	.AALEKRQTHNMVTapSSF
  867-  882 (29.24/16.22)	YARLKRMGTLH.LD..FVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.68|      16|      19|     315|     332|      13
---------------------------------------------------------------------------
  315-  332 (24.21/19.98)	LSRTIPhgIRGKALLDQC
  333-  348 (31.47/18.16)	LSKWIP..ISRAVWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.37|      14|      23|     500|     513|      15
---------------------------------------------------------------------------
  500-  513 (25.58/16.24)	EHTSSVILPTSWER
  526-  539 (22.79/13.62)	EQTDRAVFATLAER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.27|      34|      50|     161|     197|      18
---------------------------------------------------------------------------
  161-  197 (59.74/53.63)	PWRYTPPELSSCNATTSQ...DLVQVKQVQTTPYRievPS
  212-  248 (56.53/42.40)	PWTGNHPEDVLNEQTAKQghyDRTQVSQNESNTAR...PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.31|      20|      21|     704|     723|      20
---------------------------------------------------------------------------
  685-  704 (32.18/19.72)	HILSGDACLLSHLPMSRLPE
  705-  724 (32.13/19.68)	HVRSLRHTLLFRAGISGSDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.78|      11|      21|    1038|    1048|      22
---------------------------------------------------------------------------
 1038- 1048 (18.23/10.34)	KLLAPEKATPA
 1061- 1071 (18.55/10.67)	ELLIPRESKYA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04037 with Med12 domain of Kingdom Fungi
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