<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04036

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNHKIGGERRASNIHDQMNGVLSGPGNTDQTANSVDLQNGSLHVNGVGKFSDSRQNNKPASMKMVPATSREPPQLLHITQGFFPFSKLVNRSVQQCWNDLSDLIAELAEIQVSSQDSGTPSLSANGKLPGNQSPENLRKKIRAMEFAQAKRAEFIKLLVLSQWSRQAADVSKLIDIQNYIRTQHQAYSSALQWMGDMKRDLVQAQVANPDLKTALEVLSKGEVVSMPDLGYKPPKSLTPKSTLKKLQKINRIISARLALHETIPIPFQTYRVHDGRVTFVVPDEFELDLSVGEESDTSQFFFVDIRFLFNPSSSIPKGRVFSELDLKVNEILRTGGLTGCFDWLHSLVLTNKINILTKQAGELAKGLWSNVLRIELLHRTLVLQYWASTKHGTKSWLEIGIQRGGQAKKPWDQPFPTLGLRWMRDGQEVDPADVEFDTENLSVESLLRSVIALHISHILSSAYMGISAKLLFSSGALSLRAHLTKTEPGDCQLDVQLTASRKLRVAIEPMSGAIILSATPSALDRTDMDRNVDRPTVDDIIARVSRLRCGAAIEEVESKVKMFGFEPVSPRKLRFDARRVFPTGVLRISFFWNHLWERNWMLAATSSMDGDSWWVVQTRPAESANSYPILDANLHPDQAFCSAQIICNTLFPLQETGYSSLADLGHCLSGVLVMHANARFLEDLQFLKFFPPLHKLKIDSTLQVPDIMIRYEASILPQALQIALPAGFKKKTLIKDTIRLAFGGIDRQKKVAIMVAYGNLCIPSRAFSALIPKEDRSLVFQKTGTGFALRLLAPVGYPVLIALLENLQRLECVLSICETLQRKKIEPLSLSLSHICFAYGPNKDLSARLDIGVSQPMSHMEMDPVKLASRVDRLLHLHLGIRFENCNPHRRIQETLASNLNRPSADVGLDNIAELLSFTLPLMRALDRRMANPSYNEGLKMQVIVRSAKSFHIHYPNDKLRFQLVASQHLSRSVWVLKDIGSTQNGTGEDEIRRQLQESLYKSRGEGWRGLGNGVVAEPEFVGHLLDELDKHLTSIGTSLPPNPLGIQVNSGLPETVTQLLVKGQGRPPDRADNNKGMQQQPGAAATQNADIITID
Length1102
PositionTail
OrganismAspergillus rambellii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.211
Instability index43.59
Isoelectric point8.92
Molecular weight122685.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04036
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1206.80|     400|     494|      22|     461|       1
---------------------------------------------------------------------------
   22-  461 (605.88/518.14)	DQMNG..VLSG.PGNTDQTANSVDLQNGSLHvNGVGKFSDSRQ....NNKPASMKMVPATSREPPQLLHITQGFFPFSKLvnrSVQQCWNDLSDLIAELAeiQVSSQDSGT.......PSLSANGK..LPGNQSPEnlrkkiraMEFAQAkRAEFIKLLVLsqwsrQAADVSKLIDIQNY...IRTQHQA..YSSALQWM...GDMKRDLVQAQVANPDLKTALE..VLSKGEVVSMPDlGYKpPKSLTpKSTLK.KLQKINRiiSARLA...LHETIPIPFQTYrvhdgrvTFVVPDEfelDLSVGEESDTSQF.........FFVDIRFLFNPSSSIPKGRVFSELDLKVNEILRTGGLTGCFDWLHSLVLTNKINI.LTKQAGELAKGLWSNVLRIE.LLHRTLVLQYWASTKH.GTKSWLEIGIQRgGQAKKPWDQ..PFPTLGLRWMR..DGQEVDPAdveFDtENLSVESLLRSVIALHI
  514-  959 (600.91/410.01)	EPMSGaiILSAtPSALDRTDMDRNVDRPTVD.DIIARVSRLRCgaaiEEVESKVKMFGFEPVSPRKLRFDARRVFPTGVL...RISFFWNHLWERNWMLA..ATSSMDGDSwwvvqtrPAESANSYpiLDANLHPD........QAFCSA.QIICNTLFPL.....QETGYSSLADLGHClsgVLVMHANarFLEDLQFLkffPPLHKLKIDSTLQVPDIMIRYEasILPQALQIALPA.GFK.KKTLI.KDTIRlAFGGIDR..QKKVAimvAYGNLCIPSRAF.......SALIPKE...DRSLVFQKTGTGFalrllapvgYPVLIALLENLQRLECVLSICETLQRKKIEPLSLSLSHICFAYGPNKDLSARLDIgVSQPMSHMEMDPVKLASRVDrLLHLHLGIRFENCNPHrRIQETLASNLNR.PSADVGLDNiaELLSFTLPLMRalDRRMANPS...YN.EGLKMQVIVRSAKSFHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.26|      24|      30|     964|     992|       2
---------------------------------------------------------------------------
  964-  992 (34.38/30.89)	DKLRFQLVASQHLSRSV.WvlKDIGstqNG
  996- 1020 (40.88/22.58)	DEIRRQLQESLYKSRGEgW..RGLG...NG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.68|      20|      28|    1043|    1062|       4
---------------------------------------------------------------------------
 1043- 1062 (37.44/20.83)	GTSLPP....NPLGIQVNSGLPET
 1070- 1093 (33.24/17.70)	GQGRPPdradNNKGMQQQPGAAAT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04036 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVVMDNHKIGGERRASNIHDQMNGVLSGPGNTDQTANSVDLQNGSLHVNGVGKFSDSRQNNKPASMKMVPATSRE
2) VTQLLVKGQGRPPDRADNNKGMQQQPGAAATQNADI
1
1063
77
1098










Molecular Recognition Features






MoRF SequenceStartStop




NANANA