<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04032

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRVIDGFSNIYWRIYTEEQNATNTLADAPNNGHTILKHISRLKELELRLRSLGCLVLSYPRRLGLLIFSATSEFEHLLPLLANEGRDEPNRLLIGSTILKVWTSGSVTAGDLVKSLCPESQTPGVNSSTGSQRLQNGSMPPRRVDTSGGSAAIYASFISAVTAAFSLQLIRQNNAIPLGPRTLYNAVECDLYEGLDIVNNDPTSVSVLTTLQAQLTSVGKLTITLQTIAQTGLTRLSQPRDPLELSDVSPGTDLWLAPNGSIARLVTLSPVAGNTPNSLANSEGIGHDRASTKRWKSNALEWLSYFGLPVDCVEEENWVEVEVWEPFYAKLSGEAARPNEENPRIPLKRLLWPAIYCFRRTKSSISEPCDMMEGISPFACDPLEFAEKWCFTEIPKAILEPSVKLVPDHQDRQTNDQGTLSPGLPGFPDGIESLSRASLYPELQTASLVYPTPPDGAAGTGPSHPVSSDVFVEDLDHGSSFALNQTKPRLDSQPITRNRSDPDVTMGFGPSAGLVVGSGLYDTNGDDDLFGDMNERDFGTKGITDEDFSFFDEPGFENMGNNPPDDDIDGISDFVDPIKPEDIAHPEPDAPQSHEPPVEETYVRQPSPDEQKPLLPCEQPVPHDTAALPSPHDEQVQTISPPLSPVEVKKFLFPEPDAHDETSVKTGQPPSFYSPIKFKQNLSSWDQKYGAEGKFWFMSSGASRIKDSPSLSGDIPTVGLPRGRGRLNHAGIYLKARDAQGSPSSEMVQESPSSLGSSSETGDDSDDSGAENIMSPAVLSARKRKRARSNSGTSLALSSEKPPTTVDQDMSTPRTDDSVFLGNFLSTFADWSMTGFFSSTENQVFPVLTSRETQVQVAQLFVDQVTQSSLDHKLDGNFGVSCLQNQPFFLRGLLEGTEFLGGVEKLDLNGFVTLQETNSLSPPASNGPVVARQTPQRRDAGKGLIVKLSPPHLRVRRGKDFLETLPPAVSFWETFGLEPAHGPKNISAYCIHPNIAGKAADAFLERLGVIYSSCNLGNHARGDKSDAFEQGLRAWDVTSSGQSGYHSVMQHLKAICEELGTALLNGPPSKDNIVVYIINPFLHAASLVDICFAFWSLFRRYIADADKQQTKQFDELVLQVIPMSFVASPESLVVPPQPEYLSLALEVYSRCPPKPVQSSLLSCAPPVLIAEPLPGSIGFRLVSERSSPLQEGKCLHIACSRSQDQRWVSVAWSDNTGALQRSMSYCVRFRNSIAPRTIFTVRNEIWAATIDIMEKNQARWRVIIVSTENVDQDEHDTWLNFADQYNKIKSVPIELTVLSVNTTPDLFLSSPLPQIPMSIFNQHPSATPVTTPNPGIFSPDQLGNAPTPPGAGNFPANASTPTDALLEAEGESMLTDICDESWGIVLSHRLNSTLHLTEYRPALVSGYLLRRKGTSDSDGAFAMNVNLLYTQRPSSANETLLREILGMYRDLATLARARGTRIVQSSTLPWHIATAVRAQEILSYVL
Length1496
PositionKinase
OrganismAspergillus rambellii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.314
Instability index50.52
Isoelectric point4.98
Molecular weight163543.77
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04032
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     666.30|     144|     144|     460|     603|       1
---------------------------------------------------------------------------
  266-  440 (132.45/59.87)	LAPNgSIA..R...................lvtlSP...VAGNTPNSLANSEGIGHDrastkrwksnaLEWLSYFGLpvdcveeenwvevevwepfyaklsgeaarpNEENPR.I....PLKRllwpaiycfRRtkssiS......EPcDMMEGI.SPFA....CDPL..EFAEKWCF.TEI..P..................................KAILEPSVKLV..PDHQDRQTNDQ.GTLSP..GLPGFPDG
  441-  587 (234.47/111.83)	IESL.SRAslYPElQTASLV.Y.......P....TPPDGAAGTGPSHPVSSDVFVED...........LDHGSSFAL..............................NQTKPR.LD.SQPITR.........NR.....S......DP.DVTMGF.GPSAGLVVGSGLYDTNGDDDLF.GDM..NERD............................FGTKGITDEDFSFFDEPGFENMGNNPP.DDDID..GISDFVDP
  588-  731 (136.57/61.96)	IKPE.DIA..HPE.PDAPQS.H.......E....PPVEETYVRQPSP......................D......................................EQKPL.LPcEQPVPH.........DT.....AalpsphDE.QVQTIS.PP.........LSPVEVKKFLF.PEP..DAHDetsvktgqppsfyspikfkqnlsswdqkYGAEG....KF.WFMSSGASRIKDSPSlSGDIPtvGL.....P
  732-  874 (162.81/75.33)	RGRG.RLN..HAG.......iYlkardaqG....SPSSEMVQESPSSLGSSSETGDD...........SD..DSGAE..............................NIMSPAvLS.ARKRKR.........AR.....S......NS.GTSLALsSEKPPTTVDQDMSTPRTDDSVFlGNFlsTFAD............................WSMTGF....FSSTENQVFPVLTSR...ETQVQ..VAQLFVDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     276.46|      88|     172|    1115|    1217|       2
---------------------------------------------------------------------------
 1115- 1217 (133.39/81.95)	ADKQQTKQfdelvlQVIpmsfVASPESLVVPPQPEYLSLAlEVYSRCPPKPVQSSLLS..CAPPVLIAEPLPGSIGFRLVSERSSPLQ.....EGKC.LHIACsrsqDQRW
 1263- 1335 (107.00/44.35)	MEKNQARW......RVI....IVSTENVDQDEHDTWLNFA.DQYNKIKSVPIELTVLSvnTTPDLFLSSPLP.QIPMSIFNQHPS..........................
 1349- 1392 (36.07/ 8.76)	..............................................................PDQLGNAPTPPGAG.NFPANASTPTDalleaEGESmLTDIC....DESW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     461.93|     149|     892|      32|     197|       3
---------------------------------------------------------------------------
   32-  197 (218.01/199.69)	TNTLADAPNNGHTILKHISRLKElelrlRSLGCLV.LSYPR...RLG...LLIFSATSEFEHLLPLLANEGRDEPNRLLIGSTILKVWTSGSVTAGDLVKSLCpesqTPGvNSSTG..SQRLQNGsMPPRRVDTSGGSAaiYASFISAVtAAFSLQLirqNNAIPLGPRTLYNAV
  927- 1084 (243.92/171.53)	TNSLSPPASNGPVVARQTPQRRD.....AGKGLIVkLSPPHlrvRRGkdfLETLPPAVSFWETFGLEPAHGPKNISAYCIHPNIAGKAADAFLERLGVIYSSC....NLG.NHARGdkSDAFEQG.LRAWDVTSSGQSG..YHSVMQHL.KAICEEL...GTALLNGPPSKDNIV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04032 with Med13 domain of Kingdom Fungi
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