<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04029

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGATTNIHLIDGFSTIYWRIYTEESGITSHPQEGPANGYTILKHLGRLKHLEAQLRNIGCLASCPRRLGLWVFSPTPTFESLGPVYITDGDVETTKIFVDTTTLKVSASGSIACQELIKGLSSEGQNQQGSQPTPSQRPQQAQTSARRSDGYSSSVAVYSAFISAVTGALSLHLVRTHGALPIGSRTLFTAVDKTGYENPRIDNESLFSSPSLTSLNVQLNAPGTLTISTQTIVQAGITRLCSPRDDISDLFRVQPGTDLWLCPNGAIARLVTANIESQTVPSPGFTTSGDTLAKRRQWKLDVVQWLTNFGLHIDSIDEEPWVEVEVWEPFFARLAGEAWRQNDEPQSALPLKRMLWPARFCFRRTGLSIRSSWPDSSLEEPLEFAERWSSDAGSIKAAPCPQNIPAFEEPQQKDEGLSPTRVDHGESLESLSRMAQYPDLQNTNLVYPTPPEGATANGVHIATQHDPYLGDHDLLSPAVAYETKPIPDSEPSPKVDIGTGHYDASDDDDLFGEMNEKDFGSKGITDADFSFFDDPNMDDMADEMPVDQSQETPQEPVGAIPPEEEADQAHEPTAVIALHEAPKVETVPKPEEPSVPMEDDPEQSDEPMESEGPSEEPPQRPPSQTISPPLSPVEIKKILFSGSRTGDRENFEENHTQQGHYKPVTFERKLGAWDQKYGTMGKFFFSADSATKSSANDLNKIPTVGLPHRARTSISGRYKPVGKAILQTVEDGCERDSSDSTEGSSDEDEVSDDLPYEHGSTGVALPQLKRKRIPSESDIQSAASPAISSVVPDSAAGVKAENTTFLGNFLANFSDWTFTGYFSALQIQQLPVLLRREEQIPIAQLLVDQITQSSLDHSLGGNIGLFTLESEATSFTETFDDVTFLGNIQKLDLKTYTSLQEDTTETSSQSQQPTKDLSKSWISKLSAPHLRVRRGKGYLETLPPAMSFWETFGLEPAHGSKDVSAYCIHPQSATQAADVFLDRFGLSYESCNFGTHSRGDKSTGFDNGLKSWDSESPGYTSMMQALLGLCEELAAELSQSTAPNANNSVVYIINPFPHAAALADICAAFWNLFQQLVADADRRQAKQVNEVVLQIIPMEFVMSRVSMVVPTQTEYVNLAFEVYSRCRPKDAESNPLSCAPAILLAENLPKTLNFRLAPDKVSPLQDGRSLHIAYSKSCDQRWVSAAWSDGTGSLQMSMSYCLRYRNRGSSRSISEVRNEIWATTKHIMDKFQARWKVVLVSTDPMDPDEIDAWANLADQQNKMRPASLELTIVAVHTIPDLTLNTPASPMSMGVLNPHFSSTPVSTPNPNTNIASPDQTGNAPTPSAVYNAPTPTEPSLEPDSEVVLTDICDDSWAVILSHRLNASPHVTELRPALASGYLLRRKGPTDSDGVFSMTVNLLYSLRPAISHESVLGDTLAMYRDMSSLARAWGMRSVQGNTLPWHIATALRAQELLSYVF
Length1464
PositionKinase
OrganismPenicillium brasilianum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.417
Instability index54.29
Isoelectric point4.81
Molecular weight160636.29
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04029
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.18|      39|      55|     299|     337|       1
---------------------------------------------------------------------------
  257-  291 (49.46/25.89)	.RVQPGTDL..WLCPN.....G.AIARLVTAN.IESQtVPSPG.FT
  299-  337 (72.88/41.73)	KRRQWKLDVVQWLTNF.....GLHIDSIDEEPWVEVE.VWEPF.FA
  350-  390 (50.84/26.82)	PQSALPLKRMLWPARFcfrrtGLSIRS....SWPDSS.LEEPLeFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.52|      18|      18|     560|     577|       2
---------------------------------------------------------------------------
  560-  577 (31.91/15.08)	EPVG..AIPPEEEADQAHEP
  579-  598 (22.51/ 8.37)	AVIAlhEAPKVETVPKPEEP
  611-  627 (32.10/15.21)	EPME..SEGPSEEPPQ.RPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     428.08|     141|     158|     628|     777|       3
---------------------------------------------------------------------------
  628-  777 (215.27/146.86)	SQTISP..PLSPVEIK..KILFSGSRTGdreNFeENHTQQGHYKPVTFErKLGAWDQKYGTMGKFFFSADSATKSSAnDLNKIPTVGL..PHRARTSISGRYKPVgkAILQTVE..DGCERDS..SDSTEGSSDEDEVSDDLPyEHGSTGVALPQLKRKR
  789-  939 (212.81/118.75)	SPAISSvvPDSAAGVKaeNTTFLGNFLA...NF.SDWTFTGYFSALQIQ.QLPVLLRREEQIPIAQLLVDQITQSSL.DHSLGGNIGLftLESEATSFTETFDDV..TFLGNIQklDLKTYTSlqEDTTETSSQSQQPTKDLS.KSWISKLSAPHLRVRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.72|      45|    1124|     172|     217|       4
---------------------------------------------------------------------------
  133-  178 (52.84/27.86)	..QGSQPTPSqrpqqaQT..SARRSDGY.SSSVAVYSAFISAVTGALSLHL
  180-  224 (75.84/44.65)	RTHGALPIGS......RTLFTAVDKTGYENPRIDNESLFSSPSLTSLNVQL
  225-  256 (44.04/19.24)	NAPGTLTIST......QTIVQA.GITRLCSPRDDISDLF............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     297.73|      94|     845|     392|     512|       6
---------------------------------------------------------------------------
  406-  512 (145.74/122.78)	PQNIPAFEEPQQKDEGLSPTrvdhgeSLE.SLSRMAQYPDLqntNLVYPTPPEGATANGVHIA....TQHDP........YLGDHDllSPAVAYETkPIPdSEPSPKVDIGTGHYDASDD
 1252- 1358 (151.99/75.48)	PDEIDAWANLADQQNKMRPA......SLElTIVAVHTIPDL...TLNTPASPMSMGVLNPHFSstpvSTPNPntniaspdQTGNAP..TPSAVYNA.PTP.TEPSLEPDSEVVLTDICDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.00|      61|     939|      21|      86|       7
---------------------------------------------------------------------------
   21-   86 (102.42/75.68)	YWRIYTEESGITS........HPQEGPANGYTILKHLGrlkhLEAQLRNIGCLASCPRRLGL......WVfSPTPTFESL
  953- 1027 (100.59/60.83)	FWETFGLEPAHGSkdvsayciHPQSATQAADVFLDRFG....LSYESCNFGTHSRGDKSTGFdnglksWD.SESPGYTSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.97|      11|      15|    1059|    1069|       8
---------------------------------------------------------------------------
 1059- 1069 (20.87/11.89)	NPFPHAAALAD
 1076- 1086 (19.10/10.24)	NLFQQLVADAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04029 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQNTNLVYPTPPEGATANGVHIATQHDPYLGDHDLLSPAVAYETKPIPDSEPSPKVDIGTGHYDASDDDDLFGEMNEKDFGSKGITDADFSFFDDPNMDDMADEMPVDQSQETPQEPVGAIPPEEEADQAHEPTAVIALHEAPKVETVPKPEEPSVPMEDDPEQSDEPMESEGPSEEPPQRPPSQTISPPLSPVEIKKILFSGSRTGDRENFEENHTQQGHYKPVTFERKL
2) MGVLNPHFSSTPVSTPNPNTNIASPDQTGNAPTPSAVYNAPTPTEPSLEPDSE
3) PCPQNIPAFEEPQQKDEGLSPTRVDHGESLESLSRMA
4) VEDGCERDSSDSTEGSSDEDEVSDDLPYEH
444
1297
404
734
675
1349
440
763










Molecular Recognition Features






MoRF SequenceStartStop




1) QLKRKRI
2) VEIKKILFS
772
638
778
646