<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04024

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMLSDMASHDQWRTFVQRCLAHRVDVDEFKDLSKLMQSRSPLKENDLMDLLLEARAASRIAWDPLLPVYIDGLCKVGQVKTASALRRLLAHSSIRQKSESKPKMSTLMTDIKVIQDVMLSISAGAIPKRIAEAAELFGATVEWIMAIVEWHNTSVSQHAGGLMSCPDAVSLFESLGILLAALSGTSKGLETLSSDHHQELKTKLGQALTSYLPLCVDVSLPLRHRLDALQKEFNLYGEQPSKQLDHSAIEGMNVNALQFEASVMNGPLINTRAGLYVYINSMLVGRPLVDDSILINYLTNRYEGHQEALVVDITTAAFDVLCNGVHRNESSRTMFLFRTFLVNKLPAFFVALTAASMVPIPMEMCITQALSRLDPNSFPSFSQMFSMQGSSVLSDARQEFLFACASHRLIQESSIERLLGENPMQTVPVGGPYQKDDLVSQINNRPERAEQLIGEIESMEGNAGAIVGAITEVMFNLCNQKETMTLKNICNSLSRRPQTLDVILLFRTTKQVLQPLCTLLDSWRWDEDQGENQPVYDEFGSILLLVLVFKYRYDLSPADMGISSNDSFLLKLLDRGSCSQKLTELSEKQNKDLGSWIGALFIAEGINEETMSTCSPQEFYMLVATLFDQSLGACESGKLDFETLKGGFEYLLEPFLLPSLVVALTWLGNHIWQSETEPEIPLKTLFSLIKPNSISGEAQAIHKTVLHITARPLEEQLKDVRTRHQARQNIDKISDIKPILDALDPYLSFRRVGSCLRSELEVWAAPAAGGFPGSIRGTLQALTLWSASSEISLQPHSYTHRQLLAGIRILGSARVLGALIDELKQQTEAGSGDLALDIAATMICAPMPESFAVDQNICHPVDPTKESLPRCAILTLRDALSLQHENVPKISEKDPLRAQVIVRLWRRVGLLAAPPSRVSNIDVSNIIQNMELGVEGQGRMNLDATGGGVGDAGVGDDDPGNIDQMLDKAAAAAAAGMDGGVGQDMELDGGVGGMDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1021
PositionTail
OrganismPenicillium brasilianum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.039
Instability index45.61
Isoelectric point4.94
Molecular weight112059.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04024
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     607.57|     212|     300|     339|     638|       1
---------------------------------------------------------------------------
  339-  586 (297.33/297.34)	FLvnkLPAFFVALTaasmvPIPMEmcITQalSRLDPNsFPsFSQMFSM.QGSSVLSDArQeflfacASHRLIQESSiERLLGENPMQTVPVGGPYQKDDLVSQINN.....RPERAEQLIG.....EIESMEG.NAGAIVGAITEVMfnlcnqkETMTLKNICNSLSRRP......QTLDVILLFRTTKqVLqplCTLLDSWRWDEDQGENQPVYDEFGSILLLVLVFKYRYDLS...PADmgiSSNDSF....LLKLLDRGSCS.QKLTELSE
  654-  891 (310.24/289.89)	FL...LPSLVVALT.....WLGNH..IWQ..SETEPE.IP.LKTLFSLiKPNSISGEA.Q......AIHKTVLHIT.ARPLEEQLKDVRTRHQARQNIDKISDIKPildalDPYLSFRRVGsclrsELEVWAApAAGGFPGSIRGTL.......QALTLWSASSEISLQPhsythrQLLAGIRILGSAR.VL...GALIDELKQQTEAGSGDLALDIAATMICAPMPESFAVDQNichPVD...PTKESLprcaILTLRDALSLQhENVPKISE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     101.26|      25|      41|     932|     956|       2
---------------------------------------------------------------------------
  932-  949 (26.38/13.03)	..............GVEGQGR.MN..LD..ATGGGVG
  950-  975 (28.19/14.44)	DAGVGDD..........DPGN.IDqmLDkaAAAAAAG
  977-  991 (23.47/10.76)	DGGVGQ...............dME..LD....G.GVG
  992- 1019 (23.22/10.56)	GMDAIDDvlnaadmAVGNPEF.LD..LD..MEG....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04024 with Med5 domain of Kingdom Fungi
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