<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04017

Description Uncharacterized protein
SequenceMIPHSSAGQPWGHPMRTLNGGPGRVDLAQMAGQYDSPSVSSQHSISHSQLQSQPLPPPQPPIRQTPVVDLTAGGFESHDREPPPKRPRLDVSSGSNLGEAGSTMNSVEPRSTPSSAGSRPQLSWRGRPLWSFQAVISEIPGSENRGDGATASKPSSPPPFPAQPWTNVRPERQGNADSKSRDPSPVKKVSTTPYRIETPSAAPIIKGDKVAGFAPWTGNHPEDILNEQTAKQGYYDRTQVSQNESNTARPALYAQLKHRTGLQMLSSVFTAALEKRQNHNAVHAPSTFKPPPRVTLTDNKREAWLRDLANSAVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVREWTTNVQQFVEGVFSVPKSNDWKAKMTYAVGLTARLFFENLLDHDHFLEWFLASFEAASLATVPVWLLMLGIYWNNLMRYRRRGRRLAEILLEKLRQVTAAKLDPLQPLLDRLTRFVKKLVHEHTSSMILPNSWDTYKDQVSSCLNLSNKVDRALFQNIAERNARVQRPRHPKQSAQRSPHQRIIRLLDSIRSAHDITAVSSACLDTIDDRAILVSKLLEWLATPFRHGISRIYVGVRLLRKWKASGVDVDEHILSFLTHADINEKLNMDNVYHAISELVRSQTFSVGRYLQWLMAKGVTNRQPDDTLSAIETPGDIGLIAQIPVGRLPEHVGNLRKTLMARTGFSVSEEGETVANIKILICHRLPGLFRSAMLLDTSLKSLPQNMTWAVKAEIAQWLRRGVVEHTRMKANNLRAMLPGELGHSISALTSEEFYIVRDILETIGDISILADVLKVVSSSNDSTVLASVADTTNCHFDSLSVIGATMDLFRKLVDAYAGIKRYGMPSLDLMFSLIELGLRIPNELNTVAILRQDLSRMENKSVVAACSPVSDHIPDSFGEADPLFREKLDQLLLLGNVMDEPTLDTIFNMLAKHLETGEGKTKLSANDTCRYLAQLRSFQPKHFDMILARWVCGHLRSSDRTILLRILPPLIGVGCVTIRSFLSLAKRLSNSVNSIPNAADLPADLVELLVLHDEDGRYLDLVSYRFQLAQQEFISRNTEQALEIVCDAAACLKTDDQKPALRYINLETSMVTLLRELFVRNPECASRYCLQKIGDQSPAAILVFQKALDLLLGVDSQKANDSVISEVEKLANTTDDFSLPLCQLKLQVLFHADSANEDRSNLVDAMFKTVVADSRAHKLHWIDLVALMSPDAVRQIRERAEKEFFAIPLLEEPVTSQSITSLENAKLYLTIIEELASSISDSGTPSIAPLLVEKMDLLLHKIITLQSGLNNSDENRTATSAGQGRTTFERSLAFWFSALLRMVVIHRASFIQPSPTLKIGSSHEQSRLLISIFCIALSRLPGDVLRHFPGADYFPRQGAVEDCRPCPGILLQTHALDVAASLIDIFPDEIRHQCARFLKERCPPFVPLQNDSRFLYLLGPMSDSHPSSILQSASAPSPAGSASTPTPTSANFPAAGAAAQPTPSSQCGVLSENANCIANRLRLQSRGRIVGPYPIRPWELLEDAAPFVGVNDTAVNLGYFDARRVRV
Length1586
PositionKinase
OrganismPenicillium brasilianum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.200
Instability index47.95
Isoelectric point8.77
Molecular weight175828.33
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04017
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     768.94|     225|     231|     777|    1006|       1
---------------------------------------------------------------------------
  777-  959 (255.75/185.52)	................................................LRRGV.....VEHTRMKANN........................LRAMLPGELGHSISALTSEEFY.IVRDILETIGDISILAD.....VLKVVSSSN..DSTVLASVADTTNCHFD.SLSVIGATMDLFRKLV.DAYAGIKRYGM.PSL...D.........LMFSLIELGL.RIPNEL...NTVAILRQ..DLSRMENKS..VVAACSPVSDHI..PDSFGEADPLFREkLDQlllLGNVMDE
  960- 1195 (281.35/194.26)	PTLDTIFNMLAKHLETGEGKTKLSANDTCRYLAQLRSFQPKHFDMI.......larwvCGHLRSSDRT.......................iLLRILPPLIG..VGCVTIRSFLsLAKRLSNSVNSIPNAADlpadlVELLVLHDE..DGRYLDLV..SYRFQLA.QQEFISRNTEQALEIVcDAAACLKTDDQkPALryiN.........LETSMVTL.L.R...ELfvrNPECASRY..CLQKIGDQSpaAILVFQKALDLLlgVDSQKANDSVISE.VEK...LANTTDD
 1199- 1424 (231.84/156.21)	PLCQLKLQVLFHADSANEDRSNLVDAMFKTVVADSRAHKLHWIDLValMSPDA.....VRQIRERAEKeffaiplleepvtsqsitslenakLYLTIIEELASSIS..DSGTPS.IAPLLVEKM.DL.LLHK.....IITLQSGLNnsDENRTATSAGQGRTTFErSLAFWFSA..LLRMVV.IHRASFIQPS..PTL...KigssheqsrLLISIFCIALsRLPGD........VLRHfpGADYFPRQG..AVEDCRP..................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.60|      67|      69|     534|     601|       2
---------------------------------------------------------------------------
  534-  601 (105.66/76.58)	LFQNIAERNARVQRPRHPKQSAqRSPHQRIIRLLD..SIRSAHDITAVSSACLDTIDDRAILVSKLLEWL
  605-  673 (107.94/73.60)	FRHGISRIYVGVRLLRKWKASG.VDVDEHILSFLThaDINEKLNMDNVYHAISELVRSQTFSVGRYLQWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.71|      14|      69|     211|     224|       3
---------------------------------------------------------------------------
  173-  186 (22.98/12.99)	QGNADSKSRDPSPV
  211-  224 (28.73/18.39)	AGFAPWTGNHPEDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.61|      20|      69|      14|      50|       4
---------------------------------------------------------------------------
   14-   36 (28.65/45.67)	PMRTLNGGPGrVDLAqmAGQYDS
   58-   77 (37.96/13.90)	PQPPIRQTPV.VDLT..AGGFES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.25|      21|      35|     370|     390|       5
---------------------------------------------------------------------------
  370-  390 (38.39/27.19)	AVGLEAKWVREWTTNVQQFVE
  408-  428 (36.86/25.78)	AVGLTARLFFENLLDHDHFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.37|      14|      39|     111|     124|       6
---------------------------------------------------------------------------
  111-  124 (27.36/12.72)	STPSSAGSRPQLSW
  152-  165 (31.00/15.42)	SKPSSPPPFPAQPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.82|      24|      40|     301|     325|       8
---------------------------------------------------------------------------
  301-  325 (37.99/23.85)	REAWLRDlANSAVPLRRLSRTIPHG
  344-  367 (41.83/22.39)	RAVWLAK.CVGANEIRAFKRKGTSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.64|      16|      35|     706|     724|      10
---------------------------------------------------------------------------
  706-  724 (23.81/15.20)	RLPehvGNLRKTLMARTGF
  743-  758 (27.83/11.15)	RLP...GLFRSAMLLDTSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04017 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MIPHSSAGQPWGHPMRTLNGGPGRVDLAQMAGQYDSPSVSSQHSISHSQLQSQPLPPPQPPIRQTPVVDLTAGGFESHDREPPPKRPRLDVSSGSNLGEAGSTMNSVEPRSTPSSAGSRPQLSWRGR
2) PWTGNHPEDILNEQTAKQGYYDRTQVSQNESNTARPALY
3) QAVISEIPGSENRGDGATASKPSSPPPFPAQPWTNVRPERQGNADSKSRDPSPVKKVSTTPYRIETPSAAPIIKGDKVAGF
4) SILQSASAPSPAGSASTPTPTSANFPAAGA
1
215
133
1487
127
253
213
1516










Molecular Recognition Features






MoRF SequenceStartStop




NANANA