<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04007

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceMTSNGNGAHYHAASPSGALSPTHVALDKSKQMATSPHKLMMGVPPAATPKLPSAPNGNSSRQGQTSHEAHHANGTANGSALVVVDAKGKQKQVDPIDAIPLAQLEQELPLEEAGLVSLAALVERIANYGYESFQNLAETLPSLPSSSKRAKIFNTALDVRKQPIKMLVLSRWSKDLADLQKARNIIALLSEQQWQHEDVFAGLTDIRKILPNARMRNADLPTAIDVLQTGTYRRLPASIKDMAVATKPFTDQQALAIVTRLEDALRTRMACREPVPAPLSNYSIRDGKLHFSVPGLFEAQLTASSGGQDSDDDAPFPADDRWWLLDLSFDIAATGSCAESSTRSFPRKPKKAYRERLRVWGDQELAPRSQSAQNEAADEDKSDPLQATGQTAQGTPEEKPAVAGESKETGQPEESAEQNESATVKGPSKRDAPLSRLFAFLQERSLHYQMDILQHQAYELCRLNWGSNLRVETAERPRRLTLHYWTQAQGADGAAQRADSPAAGGSIQITIVDLPDRAGATKTLAMLLDDDSDPTEQTEGRTSPVAVKRRGLQGTWDAHASILADAETSNLVVSSHSLDVESLLSSVIKRHTLALLRNLQRSILVSDHAVSRLLRPEDCTLCVEHTQRQGDEFSTATEATSFSFLQIELRRSNRQRGTSIKQGSVSGVPPLRLSVDPVSGRLLLDAETTQSTTDLGSHSSAQQAATFTASILSTRPTNARLTEASDRINESMEAIFDVLYRLEVFARVEEWERMASYLGLRAVRRLNLRPQDLVKFGPSTSASPEAAPQLFIPLRNSFPGYFLALQPSELAGATIALVYVVQMMEATGAPTLAVQSIEWLDRAKIAAASKAGSDGQVDAAAAGQKRKDAPGGVQVHGSEEDANLSKKDLTMEELGDVHSYCIALVSYFRVEQQLRMQGIPYLHVGSNTSRSSPPVKRQKRLQTVHSGPRSTDARDDGLFDEEEKAGAAAVPGESTEELADDAQPATAETGVAALVPSLCLRANDLFGPARSHLTKPNVSLRIRNWDDSDKCCVQMRIKLRMKSRRFRALHEVVSFAPASDQHTTSPLTWIDFDNETSLLTLSTRDLDNCIPTFYTQWEHVMRVVQLTREVLNVSRAWQQRALRSRISCKKPTGLVELRRFNFDMVIFSYGSIAVDGSERKLLVRVRWQDPKMEMQPYTNMPLTQSGGYILEFGSIPIADVESLDNQIFADADATAEAPQVGAGAARKEEDTVSKWFDDVHASANPHNVMAFELRRTVNVAARTAAMHSTVQPHSERTVWRGFFKLLQDTLALVREMAPLAEKCLTEPDVPEVEIKSATWFRLRFQDRYALDLRLVTRSSLIAGKAPSADSAAKAKNRIAATATAPSNHIGSPATAAAMEFQPIPNIDLVLRK
Length1392
PositionTail
OrganismSporisorium scitamineum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Sporisorium.
Aromaticity0.06
Grand average of hydropathy-0.395
Instability index51.17
Isoelectric point6.32
Molecular weight152626.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04007
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     595.48|     170|     373|     685|     883|       1
---------------------------------------------------------------------------
  560-  679 (136.72/64.55)	ASILADAET.SNLVVSSHSLD..VESLLSSV.IKRHTLALLRNLQR.S..ILV......SDHAVSRL.LRPEDCTlcvehtqRQGDEFSTATEAT.........SFS..FLQI...ELRRSNRQRGTSIKQGSVSGVPplRLSVDPVS...............................................
  709-  883 (262.19/188.05)	ASILSTRPTnARLTEASDRINesMEAIFDVL.YRLEVFARVEEWERMA..SYL......GLRAVRRLNLRPQDLV.......KFGPSTSASPEAAPQLFIPLRNSFPGyFLALQPSELAGATIALVYVVQMMEATGAP..TLAVQSIEWLDRAKIAAASKAGSDGQVDAAAAgQKRKDAPGGV..QVHGSEEDAN
 1098- 1247 (196.57/101.66)	........................EHVMRVVqLTREVLNVSRAWQQRAlrSRIsckkptGLVELRRFNF...DMV.......IFSYGSIAVDGSERKLLVRVRWQDPK..MEMQPYTNMPLTQSGGYILEFGSIP........IADVESLDNQIFADADATAEAPQVGAGAA.RKEEDTVSKWfdDVHASANPHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     361.19|      89|     851|     423|     525|       2
---------------------------------------------------------------------------
    7-   47 (15.69/17.87)	...............................................................GAHYHAASPS...GALSPTHVALdksKQMATSPHklmmgvpPAA
  437-  525 (152.64/80.60)	LFAFLQERSLHYQMDILQHQAYELCRLNWGS......NLRVETAERPRRL.TLHYWTQAQGADGAAQRADSPA.AGGSIQITIVDL...PDRAGATK.......TLA
 1005- 1066 (68.70/31.17)	LFGP..ARS.H.....LTKPNVSLRIRNWDDsdkccvQMRIKLRMKSRRFrALHEVV..SFAPASDQHTTSP...................................
 1295- 1376 (124.16/62.99)	EMAPLAEKCL.TEPDV...PEVEIKSATW.........FRLRFQDR.YAL.DLRLVTRSSLIAGKAPSADSAAkAKNRIAATATAP...SNHIGSPA.......TAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.32|      14|     374|      48|      61|       4
---------------------------------------------------------------------------
   48-   61 (25.94/13.91)	TPKLPSAPNGNSSR
  395-  408 (21.24/ 9.97)	TPEEKPAVAGESKE
  423-  436 (22.14/10.72)	TVKGPSKRDAPLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.03|      40|      66|      94|     136|       5
---------------------------------------------------------------------------
   94-  136 (57.57/51.99)	DPIDAIPLAQLEQELP.LEEAGLVsLAALVERiaNYGYES.FQNL
  162-  203 (60.45/42.64)	QPIKMLVLSRWSKDLAdLQKARNI.IALLSEQ..QWQHEDvFAGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.97|      18|      22|     910|     930|       6
---------------------------------------------------------------------------
  910-  930 (27.41/22.59)	VEQQLRMQGIpylHVG..SNTSR
  935-  954 (26.56/13.15)	VKRQKRLQTV...HSGprSTDAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.40|      13|     148|     378|     391|       7
---------------------------------------------------------------------------
  378-  391 (20.86/13.74)	DEDkSDPL.QATGQT
  529-  542 (21.54/ 9.67)	DDD.SDPTeQTEGRT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04007 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYLHVGSNTSRSSPPVKRQKRLQTVHSGPRSTDARDDGLFDEEEKAGAAAVPGESTEELADDAQPAT
2) MTSNGNGAHYHAASPSGALSPTHVALDKSKQMATSPHKLMMGVPPAATPKLPSAPNGNSSRQGQTSHEAHHANGTANGSALVVV
3) QVDAAAAGQKRKDAPGGVQVHGSEEDANLSKKDL
4) RLRVWGDQELAPRSQSAQNEAADEDKSDPLQATGQTAQGTPEEKPAVAGESKETGQPEESAEQNESATVKGPSK
919
1
856
356
986
84
889
429










Molecular Recognition Features






MoRF SequenceStartStop




1) FPADDRWWLLD
2) KAKNRIA
316
1353
326
1359