<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03994

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGSSVEEWRKLLHQCLIRRIDANEFKTLAKLLARRAPLAEASLLDVVLESRAVANAQWDPLVPLYVDTLTKLGTVRIPTVLQSLLKHSSIGEQQQQQQQQQQSAAAPDNKQKSRGQHLSTTLMTDTRIIQDAMIALSTGSVPISATDAARIFTAVADWILEVVRWHTSHVNEDQQTGGLMGSPDAISLFESLGILLAALSATEKGLEALSSDNSEAFKIKLGQALTAYLPLCAGVSVPLRNRLDSLQKGFELYGEPNSKSLDVPMMDGVNVNALQFEASVMDGPVINSRAGLYIYLNAMGHHEVLIQELITASFDVLSNAMYRNESSRTMFVFRSFLVNKLPPFLASMAAASMEPIQMEVCISHALNRLDPNAFPSFSQMFEMHGNTVLSDVRQEFLFACALHRLIPESSIERLLGENPMQTLPVGGKYIKDELVSQITADHERADQLIAEMEAMEGNAAAIVGAVTEVIHSLCNQKETVTLKTICNSLSRRPQVLDVILLFRSPKTILQPLCSLLDAWRWDEDQGENQPVYDEFGSVLLLVLAFKYRYDLSQYDLGISNSQSFVLKLLDRGSSSQKLDDLGEKQHKNLGAWISALFIAEGISEETMSSCSPQEFYLLVSTLFSQSIGACEAGKLEFDTLKGGFEYLLEPFLLPSLVIALTWLGNYIWESETDPTIPLKVLHSLVKPNSISGEAEAIHRTVLYITARTLEEQLKDVRTRHPGRSDIKPILDALEPYLSFQRTGSSHRAELESWTSHSGGLTGSIRNTFHSLVLWSTNPEISMSPHSYTHRQLLAGVRILGATRVLPALIEELKLQTEAGSGDLAIDIAATLICSPMAESFAVDQAIYRPVDPNKEALPRCPILTLRDALVFQHENVPKIAEKDPLRAEVIVRLYRRVNALLAPPSHVNNLDVSNIIDNMNLEGGVGGHDQMDLGSADPQMTGTGMGGSEENIDRMLNEAAAAAGGVNNGAPPQGVGLDGAGSGPGTGMDTSIDDMLNAADMGVGNPEFLDLDMEGMF
Length1017
PositionTail
OrganismRasamsonia emersonii CBS 393.64
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Rasamsonia.
Aromaticity0.06
Grand average of hydropathy-0.066
Instability index41.80
Isoelectric point4.96
Molecular weight111293.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03994
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.07|      29|      40|     923|     962|       1
---------------------------------------------------------------------------
  923-  946 (20.61/21.93)	.................GGVgghdqmDLGSADPQ...MTGTGMG
  947-  983 (41.54/32.37)	GSEENIDRMLNeaaaaaGGV......NNG.APPQgvgLDGAGSG
  987- 1014 (41.93/25.03)	GMDTSIDDMLN.............aaDMGVGNPE...FLDLDME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.16|      18|      40|      27|      44|       2
---------------------------------------------------------------------------
   27-   44 (28.52/18.71)	TLAKLLARRAPLAEASLL
   68-   85 (28.64/18.81)	TLTKLGTVRIPTVLQSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.76|      28|      36|     339|     372|       3
---------------------------------------------------------------------------
  345-  372 (48.13/37.04)	LASMAAAS.MEPIQMEVCISHALNRLDPN
  380-  408 (45.63/21.49)	MFEMHGNTvLSDVRQEFLFACALHRLIPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     197.23|      46|     344|     485|     530|       4
---------------------------------------------------------------------------
  421-  464 (42.18/27.72)	QTLPV.....GGKYIKDELVSQITADHERADQ.....lIAemeamegNAAAIVG
  465-  493 (42.57/28.05)	AVTEVI..........HSLCN.......QKETVTLKT.IC.......NSLSRRP
  494-  536 (69.37/50.90)	QVLDVILLFRSPKTILQPLCSLLDAWRWDEDQGENQP.VY.......DEFG...
  537-  566 (43.11/28.52)	SVLLLVLAFK...............YRYDLSQ.YDLG.IS.......NSQSFVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.72|      19|      36|     744|     762|       5
---------------------------------------------------------------------------
  742-  760 (35.08/23.91)	TGSSHRA..ELESWTSHSGGL
  761-  779 (18.67/ 9.01)	TGSIRNTfhSLVLWSTNPE..
  783-  793 (15.98/ 6.57)	..SPH.......SYT.HRQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.82|      30|      68|     243|     274|       7
---------------------------------------------------------------------------
  199-  229 (42.26/28.03)	LSATEKGLEALSSDNSEAFKIKL..GQALTAyL
  243-  274 (46.56/39.41)	LDSLQKGFELYGEPNSKSLDVPMmdGVNVNA.L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.18|       9|      18|     818|     828|      10
---------------------------------------------------------------------------
  818-  828 (10.41/13.22)	AGSgdLAIDIA
  837-  845 (15.78/ 9.21)	AES..FAVDQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03994 with Med5 domain of Kingdom Fungi
Unable to open file!