<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03992

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceVDPSQSSNPLKRIAWPARYCFKRTRAASSTYFEGVNSPIKDSDDPLQFAEDWLAEAGSRNEKLASRSSALSQAQQNKDMSTPKTDIPDNIESLARIAQYPDLQAASLVYPTPPDGALVQGMIHIGSDMFGTEGSDLAASQTPGERLPVKREEQTSDVIVSGFGPSNGLGVGSGMYDTNDDEDLFGEMNEKDFGSKGISDADFSFFDEPDFGSLDNDRAKGDTQEHQQTSSLSQVPEAKAAPEDIPAEKSLESQGISVEPAETDIGAVAAPKSNLTVDTSVKAPSGPQETLPEDRPPSRSRQTISPPLSPVEIKKILFSNPQSGQPGRGEGSGNPTIDKNARRQSNYDPVAFQQDLAMSDRKYGANGRFFFSEKTNAATAATREDTQIPTVGFPRGQKSRSENHIDHRATGSQQQTPIHSTQPRLRSPSVSSDETTDDTSDDISQRAASPTRFTGLKRKRPASQADNSTTSSSEGLSTAPDVDVTTSKEENSVFLGNFLSAFSDWSLAGYFSTRQNQFSPVLLRKEDQIQLAQLMVDQVTQSSLCHKVDGCMGLPDLEHDALSLRTFLEDTTIMGDIERLDLKTYVSLQDSSHIAANESSRQNTQRKDIKGSITKLPPPHLRIHRGRDFLEVLPPAISFWETFGFEPANGTKNISAYCIYPQNAKEGADAFLDRLGFLYSSCNLGKHVRGDRSKTFENGLGAWHVTLGGNSGYLSTMQSLRTLCEGLGTALSKAPPVRDNFVIYIINPFTHGAALADICSAFLQLFQKYVGDVDRHQARQQLNELVLQVVPMSFISSPSSLVVPTQTEYLNLALEVYNRCPPKDTSSGVMGCAPPVLLAESVPKSINFRLAPERTSPFQEGKCLHLALSRSLDQRWISAAWSDGSGSCQVTLSYCLRTRGSSISRMVSDVRHEIWETTKDIMERTQTRWKIFLVRTEPTDQEDIDAWTGLVERYNQMRSMPVELTILSVNIAPGLRLELPSSQIQLNTMNSQTSSTPVTTPHAGMPSPDQFGGSAATPTSSSQGPANAPTPTDISSIMEPESDAVLIDAADESWGIILSHRLSNSLFMTEYRPALASGYLLRRKGVSESQGVVAMGVNLVYTQRPPASYETVLRETLGMYRDLATLARAKGTLHVQRNTLPWHIATAVKGQELLSYIL
Length1157
PositionKinase
OrganismRasamsonia emersonii CBS 393.64
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Rasamsonia.
Aromaticity0.07
Grand average of hydropathy-0.490
Instability index50.94
Isoelectric point5.28
Molecular weight126452.51
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03992
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     463.38|     138|     142|     292|     433|       1
---------------------------------------------------------------------------
  161-  316 (154.40/84.56)	..........GFG.PSNGLGVGSGMYDTNDDEDLFGE.....MNEKDFGSKGisdaDFsFFDEPDFG.SLDNDRakGDTQ.......EHQQTSSLSQVP.EAKAAPEDIPAEKS...LESQGISVEPaetdigavaapksnltvdtsvkapsgpqetlpEDRPPSRSRQTISPP.LSPVEIKKIL
  318-  461 (215.24/130.02)	SNPQSGQPGRGEG.SGNPTIDKNARRQSNYDPVAFQQDL..AMSDRKYGANG....RF.FFSEKTNA.ATAATR..EDTQIPTVGFPRGQKSRSENHIDHRATGSQQQTPIHSTqprLRSPSVSSDE..............................ttDDTSDDISQRAASPTrFTGLKRKRPA
  462-  549 (93.74/44.86)	SQADNSTTSSSEGlSTAPDVDVTTSKEEN...SVFLGNFlsAFSD..WSLAG.......YFSTRQNQfSPVLLR..KEDQIQLAQLMVDQVTQS..SLCHKVDG.................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.27|      47|     377|     598|     679|       2
---------------------------------------------------------------------------
   67-  115 (77.66/30.27)	SSalSQAQQNKDMSTPKTDIPDNIESLARIAQYPD.LQAASLVYPT....PPDG
  598-  649 (75.61/85.69)	SS..RQNTQRKDIKGSITKLPPPHLRIHRGRDFLEvLPPAISFWETfgfePANG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03992 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FGTEGSDLAASQTPGERLPVKREEQTSDVIVSGFG
2) LASRSSALSQAQQNKDMSTPKTDIPDNIESL
3) RKYGANGRFFFSEKTNAATAATREDTQIPTVGFPRGQKSRSENHIDHRATGSQQQTPIHSTQPRLRSPSVSSDETTDDTSDDISQRAASPTRFTGLKRKRPASQADNSTTSSSEGLSTAPDVDVTTS
4) SFFDEPDFGSLDNDRAKGDTQEHQQTSSLSQVPEAKAAPEDIPAEKSLESQGISVEPAETDIGAVAAPKSNLTVDTSVKAPSGPQETLPEDRPPSRSRQTISPPLSPVEIKKILFSNPQSGQPGRGEGSGNPTIDKNARRQSNYDPVAFQQDLAMS
5) SQIQLNTMNSQTSSTPVTTPHAGMPSPDQFGGSAATPTSSSQGPANAPTPTDISSIMEPE
129
63
360
203
981
163
93
486
358
1040










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEMNEKDF
2) KGISDADFSFFDEP
3) PLQFAEDWLA
4) SNPLKRIAWPARYCFKRTRAASSTYFEGVN
5) SPPLSPVEIKKILFSNP
184
195
45
7
304
192
208
54
36
320