<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03986

Description Mediator of RNA polymerase II transcription subunit 20
SequenceMPITGVFFIPSTPNAPNALATLSERLRSSYGDEAVPVGRWALEHKLMRDTSSCLPASAHAPNPPPQPRYMQFLSLSHYPNHGFIYASESTDQPDTNAPGLAQQPPRKPSTQSGMIMSTIPLPSCSTLFQHFVRACEPLWCHRHTVTAGGTTYDVGDFRVRIGEVRQTQPMARARGTVVEIEWRGPSIASSPLLSPLPTDGDGSGDYADSAVDLSFIPEDSDIDAEYAQTAELIREFWSRFGVTDKGVQEAILVPDVGRELKAKLHQRRQSGWRELEAKRRQKKNEAAALGRSWGWGWNEQDDDPDAGVDLARQYMEIFRFNR
Length322
PositionHead
OrganismRasamsonia emersonii CBS 393.64
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Rasamsonia.
Aromaticity0.09
Grand average of hydropathy-0.563
Instability index58.97
Isoelectric point5.79
Molecular weight35849.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03986
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.37|      18|      23|     189|     210|       1
---------------------------------------------------------------------------
  193-  210 (33.94/27.92)	LSPLPTDGDGSGDYADSA
  213-  230 (32.43/15.61)	LSFIPEDSDIDAEYAQTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.00|      13|      23|     262|     274|       2
---------------------------------------------------------------------------
  262-  274 (25.06/14.09)	AKLHQRRQSGWRE
  287-  299 (27.94/16.49)	AALGRSWGWGWNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.24|      17|      40|      63|      79|       5
---------------------------------------------------------------------------
   63-   79 (34.89/18.79)	PPPQPRYMQFLSLSHYP
  104-  120 (32.35/16.96)	PPRKPSTQSGMIMSTIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03986 with Med20 domain of Kingdom Fungi
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