<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03984

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDGESFTLPLRPLVEKGGKKDTLPVRIAQINAQRGSFRDVTEESLQAEIEARKERGAELEEEEEEEEKEKAVEEKKPPELDATERHELLYKRRAEIIQFAAQAHMEAIFALDFISLLLSKHMPRQAETSISPHLKQKVPLGSLNVDVIKTPEKSASAQRDTTTVARGWRLESFNAAANKLLKAASRLENEVAAETKYWEEVLAVKEKGWKVCRLPRERQALGVQYGFLEATPTFRDRGLASLRRADDGSLVLDRGLAPSRPRVVRIRVKKNNQVTGCSKLSQFMAAADDSIENRILRSRDILFEEELFHELTREARILASSGVTTRRNLIQFEFSEGEEILFDLVDLDDVPDEADVTYRTPEHDTLAEAVAHAVRILLSYAHRQNLQRRTQIPPPLTTKKRPVPEYQLLRPILAYLQHSSHVQSLRSFLRDLYRILKSAGLKSEYTAAPFASLDLLRKEGHASAVESLVKHFLDPLESRFSGTMANQTSTFNAKVRTNLSGPSLGTEYEFSIRLPNFPHTQPPSRVGLKDEVEAVIRHLITLDLTTFISSISKNASNAKAAAATTPTSDKLLVWEAPFAHHGELVALSPSTQRTKKLSLHLSRTELTLRTSWLGDESVGGVDDGQRQAGKLLYSWTLDDADKPGRKTLEEVIAEASRDEEVKSEA
Length665
PositionHead
OrganismRasamsonia emersonii CBS 393.64
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Rasamsonia.
Aromaticity0.06
Grand average of hydropathy-0.495
Instability index43.36
Isoelectric point6.34
Molecular weight74695.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03984
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.98|      20|      38|     413|     438|       1
---------------------------------------------------------------------------
  413-  432 (36.10/27.37)	LAYLQ...HSSHVQSL.RSFLRDL
  453-  476 (25.88/ 7.70)	LDLLRkegHASAVESLvKHFLDPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.09|      37|     194|      15|      56|       2
---------------------------------------------------------------------------
   15-   56 (58.25/48.05)	EKGGKKDTLPVRIAQINAQRG......SFRDVTEESLQaeieaRKERG
  206-  248 (61.84/40.15)	EKGWKVCRLPRERQALGVQYGfleatpTFRDRGLASLR.....RADDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.38|      21|     289|     347|     375|       3
---------------------------------------------------------------------------
  347-  375 (27.09/30.55)	LDDvpdeADvtyrTPEHDTLAEAVAHAVR
  637-  657 (37.29/19.29)	LDD....AD....KPGRKTLEEVIAEASR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.54|      11|      14|     169|     179|       6
---------------------------------------------------------------------------
  169-  179 (18.58/13.09)	RLESFNAAANK
  186-  196 (17.96/12.41)	RLENEVAAETK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.39|      14|      14|     110|     123|       7
---------------------------------------------------------------------------
  110-  123 (24.75/16.22)	ALDFISLLLSKHMP
  126-  139 (23.64/15.19)	AETSISPHLKQKVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03984 with Med17 domain of Kingdom Fungi
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