<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03984

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDGESFTLPLRPLVEKGGKKDTLPVRIAQINAQRGSFRDVTEESLQAEIEARKERGAELEEEEEEEEKEKAVEEKKPPELDATERHELLYKRRAEIIQFAAQAHMEAIFALDFISLLLSKHMPRQAETSISPHLKQKVPLGSLNVDVIKTPEKSASAQRDTTTVARGWRLESFNAAANKLLKAASRLENEVAAETKYWEEVLAVKEKGWKVCRLPRERQALGVQYGFLEATPTFRDRGLASLRRADDGSLVLDRGLAPSRPRVVRIRVKKNNQVTGCSKLSQFMAAADDSIENRILRSRDILFEEELFHELTREARILASSGVTTRRNLIQFEFSEGEEILFDLVDLDDVPDEADVTYRTPEHDTLAEAVAHAVRILLSYAHRQNLQRRTQIPPPLTTKKRPVPEYQLLRPILAYLQHSSHVQSLRSFLRDLYRILKSAGLKSEYTAAPFASLDLLRKEGHASAVESLVKHFLDPLESRFSGTMANQTSTFNAKVRTNLSGPSLGTEYEFSIRLPNFPHTQPPSRVGLKDEVEAVIRHLITLDLTTFISSISKNASNAKAAAATTPTSDKLLVWEAPFAHHGELVALSPSTQRTKKLSLHLSRTELTLRTSWLGDESVGGVDDGQRQAGKLLYSWTLDDADKPGRKTLEEVIAEASRDEEVKSEA
Length665
PositionHead
OrganismRasamsonia emersonii CBS 393.64
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Rasamsonia.
Aromaticity0.06
Grand average of hydropathy-0.495
Instability index43.36
Isoelectric point6.34
Molecular weight74695.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03984
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.98|      20|      38|     413|     438|       1
---------------------------------------------------------------------------
  413-  432 (36.10/27.37)	LAYLQ...HSSHVQSL.RSFLRDL
  453-  476 (25.88/ 7.70)	LDLLRkegHASAVESLvKHFLDPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.09|      37|     194|      15|      56|       2
---------------------------------------------------------------------------
   15-   56 (58.25/48.05)	EKGGKKDTLPVRIAQINAQRG......SFRDVTEESLQaeieaRKERG
  206-  248 (61.84/40.15)	EKGWKVCRLPRERQALGVQYGfleatpTFRDRGLASLR.....RADDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.38|      21|     289|     347|     375|       3
---------------------------------------------------------------------------
  347-  375 (27.09/30.55)	LDDvpdeADvtyrTPEHDTLAEAVAHAVR
  637-  657 (37.29/19.29)	LDD....AD....KPGRKTLEEVIAEASR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.54|      11|      14|     169|     179|       6
---------------------------------------------------------------------------
  169-  179 (18.58/13.09)	RLESFNAAANK
  186-  196 (17.96/12.41)	RLENEVAAETK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.39|      14|      14|     110|     123|       7
---------------------------------------------------------------------------
  110-  123 (24.75/16.22)	ALDFISLLLSKHMP
  126-  139 (23.64/15.19)	AETSISPHLKQKVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03984 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TEESLQAEIEARKERGAELEEEEEEEEKEKAVEEKKPPELDATER
41
85










Molecular Recognition Features






MoRF SequenceStartStop




1) FTLPLRPLVEK
2) LPVRIAQIN
3) QRQAGKLLYSWTLDDADK
4) RKTLEEVIAEASRDEEVKSEA
6
23
625
645
16
31
642
665