<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03983

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIVMEDASDSGSRRWTSPHDLHENNGQPNSVRATENNGALADSEKASRQLNGSSKEPGSLDRRPNMTNDHPQKMARAEESTQAPRQPPPELVHITQGFSPYGQLVNRAVQQCWNDLSDLITELADIQVSTQQQPSQLTLPNGKPSGNQSTENVQKKLRLLEFLQNKRAEFIKLLVLSQWSRQAADVSKLIDLQGFIRTRHMAYNAAIQRVADMKRDLVRAQVANPDLATALEVLSTGRVSSMPDLGYKPPKPLTAKGLLRTLRKINRIISTRLILHDSVPAPFHNYRVHDGRVTFIVPKEFEIDLSIAEEDPHSQFYFIDIRFLFSPSSPIPKGRFFNELDLRINNILRTEGLAGCFDFVHNLVLSNKINILFRQAVDLIRGQWSDALRVELLRRTLVVQYWANKPGPKSWLEIGIRSGRQKTSAGERAPRVSHLGLRWIRENKEVDSTDISFDTENLSIESILRSAIALHTSHWLRSAYARFSVEPLFATRSLSLRAQTSTIEPGDCYLNVQLTRSRYLCASVEPVSGNICLRTTPTPLSLLDKDRNADDLVARISRLRCIAAMEEIEANAKMLGWEIVDHRKLKVDIRRLFPPNILRASFFRHRLWQPGWIVAATTSLSGDDWWVLQLKPRPSPNPNLQHLHSSASSEGFLIQSTRVVVGNLVTAHQQLSYSFFANLEHSLAGIIAMHANASWLADLRSLHSFPTAQNLQLGRNLEVPHLSIRFDTSKLPEALRMHPPAGIRKKSYVKETISLSYHGFDPRAKAVIVVAYGRFHAPLRNLGLRTLKLDDSVILQRRGSGFAIRFLVAAGQSIIAELCERVQRLEIVLSVFESLRRNKVKIRTLSLSRLSFVYAPEQDLSASIVVRLSGPDSLADLEPAALRSETTSLFRLRLDISFAESNPHSRIRQSLAAILNQDSYAGIDSVIRLLTFTLPLLRALDRLVTQPSCNPSLTVQVTARGAKTYQFRYSGLRFRFLLTAGYRRDGMIWVLKDIGSSREKREGEEVIASKLQERIYDSKGDGWQGLGNGAVADADKVGNLITELDSCFADVATMASSGDGKDADAGQMSAETKGPGGSTSVDAPGRAAGTNANTSQAPDKPAGPDVIMID
Length1112
PositionTail
OrganismRasamsonia emersonii CBS 393.64
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Rasamsonia.
Aromaticity0.07
Grand average of hydropathy-0.297
Instability index50.53
Isoelectric point9.50
Molecular weight123916.76
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03983
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.85|      35|      36|     455|     489|       1
---------------------------------------------------------------------------
  455-  489 (60.90/36.92)	FDTENLSIE...SILRSAIALHTSHWLRSAYARFSVEP
  491-  528 (56.95/34.06)	FATRSLSLRaqtSTIEPGDCYLNVQLTRSRYLCASVEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.63|      34|      38|     318|     355|       2
---------------------------------------------------------------------------
  318-  355 (50.49/44.96)	FYFIDiRFLFSPSSPIpkgRFFNELDL...RINNILRTEGL
  359-  395 (51.13/31.48)	FDFVH.NLVLSNKINI...LFRQAVDLirgQWSDALRVELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.24|      16|      32|    1062|    1077|       4
---------------------------------------------------------------------------
 1031- 1049 (19.59/10.47)	GAVADAdkvGNLITELDSC
 1062- 1077 (27.92/18.26)	GKDADA...GQMSAETKGP
 1091- 1106 (26.73/17.14)	GTNANT...SQAPDKPAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.69|      29|      43|      13|      52|       5
---------------------------------------------------------------------------
   13-   41 (54.41/48.70)	GSRRWTSPHDLHEN..NGQPNSV.RATENNGA
   54-   85 (43.28/19.08)	GSSKEPGSLDRRPNmtNDHPQKMaRAEESTQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.56|      25|      43|      87|     113|       6
---------------------------------------------------------------------------
   87-  113 (36.18/34.52)	RQPPPELVhITQGfSPYGQLVNRAVQQ
  133-  157 (44.38/29.88)	QQQPSQLT.LPNG.KPSGNQSTENVQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.19|      19|      37|     578|     596|       8
---------------------------------------------------------------------------
  578-  596 (34.74/22.31)	GWEIVDHRKLKVD...IRRLFP
  613-  634 (27.45/16.12)	GWIVAATTSLSGDdwwVLQLKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.11|      50|     167|     758|     813|      10
---------------------------------------------------------------------------
  758-  813 (79.34/66.46)	SYHGFD..........PRAKAVivvayGRF.HAPLRNLGLrTLKLD..DSVILQRRGSGFAIRFLVAAG
  921-  983 (73.77/46.83)	SYAGIDsvirlltftlPLLRAL.....DRLvTQPSCNPSL.TVQVTarGAKTYQFRYSGLRFRFLLTAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.48|      30|     175|     676|     731|      11
---------------------------------------------------------------------------
  676-  710 (48.07/57.97)	SFFANLEHSL.AGIIAMHANASWLADLRslhsfPTA
  853-  883 (47.40/15.34)	SFVYAPEQDLsASIVVRLSGPDSLADLE.....PAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.01|      15|     588|     303|     317|      16
---------------------------------------------------------------------------
  303-  317 (27.55/17.80)	FEIDLSIAEEDPHSQ
  894-  908 (27.46/17.72)	LRLDISFAESNPHSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03983 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDGKDADAGQMSAETKGPGGSTSVDAPGRAAGTNANTSQAPDKPAGPDVIMID
2) MPGIVMEDASDSGSRRWTSPHDLHENNGQPNSVRATENNGALADSEKASRQLNGSSKEPGSLDRRPNMTNDHPQKMARAEESTQAPRQPPPELVHITQG
1060
1
1112
99










Molecular Recognition Features






MoRF SequenceStartStop




NANANA