<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03978

Description RNA polymerase III transcription factor subunit
SequenceMADRHGDRTAPFYSIPPRQIVGVEHPGVVKNVDRAIATLHGNDGIAKVGPVSGHTETERRDAKTLLRSLRDNVGKYTIEPVGRVERTHVFRGIPDFVFSTASSPFTQKFREHILPFDSLLTIIQCAVEKMKGFDISMSKGEVRNVDIIPPPSFSVGDVPFQYTYRQNPTVKQSVDTTGKITTVNTQQSSKVLTHLVPYDIPVVPSKPRENCPPISSLDKTLQETIAALEALFAERPAWTRRGLRNSLKSNEQRYCLRHAIAYVGYIFRSGPWRDAIVKLGHDPRSSPDYRIYQTFVFRILPREPELARDGGGGRRHTLPRPSETVNDPSKDGTSNTHLFTGKPPLPLDGKIWMVCDLVDPILRQILMPENPPPNFLRSTCDWICDGWYGNGTLAKARTIIRAKIHAMTQQNRVPDDSEFMRILSFPDHADADDNLAAFHLDPETATSREMQLATEVRATIKGAPNWKAAGMDHRQRTARNQPHTPTATAVEIAGTDDTAAAAAAAAAEAKEVRWEDEDEAEAARRLVEEEEESEGEEEAIEREEIAAAVAAEEAQQQQQQQLRPKLDEANSDEEMMADEDEEEEEEEEEEEEDEEEEEEEDDDEDQELDPENMDLEKGEEDDEDEV
Length626
PositionTail
OrganismRasamsonia emersonii CBS 393.64
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Rasamsonia.
Aromaticity0.06
Grand average of hydropathy-0.755
Instability index59.14
Isoelectric point4.68
Molecular weight70363.08
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell
transcription factor TFIIIC complex	GO:0000127	IEA:InterPro

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW

GO - Biological Process
transcription initiation from RNA polymerase III promoter	GO:0006384	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03978
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.46|      20|      20|     585|     604|       1
---------------------------------------------------------------------------
  585-  604 (35.04/13.21)	EEEEEEEEDEEEEEEEDDDE
  606-  625 (31.42/11.25)	QELDPENMDLEKGEEDDEDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.70|      19|      54|      93|     111|       2
---------------------------------------------------------------------------
   93-  111 (34.97/18.64)	IPDFVFSTASSPFTQKFRE
  148-  166 (37.72/20.58)	IPPPSFSVGDVPFQYTYRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      78.36|      15|      61|     507|     521|       3
---------------------------------------------------------------------------
  487-  501 (17.76/ 7.24)	ATAVEIAGTDDTAAA
  507-  521 (26.41/14.50)	AEAKEVRWEDEDEAE
  527-  538 (17.03/ 6.63)	VEEEE...ESEGEEE
  570-  583 (17.17/ 6.75)	.NSDEEMMADEDEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.84|      23|      27|     262|     284|       4
---------------------------------------------------------------------------
  262-  284 (44.04/24.08)	YVGYIFRSGPWRDAIVKLGHDPR
  292-  314 (41.80/22.52)	YQTFVFRILPREPELARDGGGGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.25|      21|      81|     387|     408|       7
---------------------------------------------------------------------------
  387-  408 (33.45/25.53)	WYGNGTLAKARTiIRAKIHAMT
  466-  486 (39.80/26.16)	WKAAGMDHRQRT.ARNQPHTPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03978 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNLAAFHLDPETATSREMQLATEVRATIKGAPNWKAAGMDHRQRTARNQPHTPTATAVEIAGTDDTAAAAAAAAAEAKEVRWEDEDEAEAARRLVEEEEESEGEEEAIEREEIAAAVAAEEAQQQQQQQLRPKLDEANSDEEMMADEDEEEEEEEEEEEEDEEEEEEEDDDEDQELDPENMDLEKGEEDDEDEV
2) RDGGGGRRHTLPRPSETVNDPSKDGTSNTHLFT
433
308
626
340










Molecular Recognition Features






MoRF SequenceStartStop




1) QLRPKLDEA
561
569