<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03976

Description RNA polymerase II mediator complex component Srb8
SequenceMPGCIVTRCHITSQYTALSSCDGHWAVIIRYGTVSAAAAKQKPEGAPTARRRVFSSPHIPAAVIYRQHWAPHSNPITSAAFNSPFTRFRNAGTLPNPFRDVQSLQCPDVQRSERRHASDVPAMIPHSSSGVQPWVNQSRIPSGSRAGDSTGSVALSSAALPDKPSMAAAPPNGHQTVIDLTSNDSTTPESEHPSKRPRLDTNVSGPAGDGKTRSAELRSASASGTPRPATVPGRGRPACSFQELVSETYGAGFSSGNLTPGSQTTKPASPPPFPIRPWKYASSQQSGSGTAVANESTPEREVQTTPYRLEVPSIAPILKGDKFADFSPWTGNHPEDLLSEQTTKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQVLSSVFAAALEKRQAHNKVASASTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLSKWIPIGRAVWLAKCVGANEIRAFKRKGTSGSLALGLEVKWVRDWTTAVQQFLEGVVSSCGKEDWKMKMTYSVRLTARLFFENLLDQDCYLDWYLSSLENATLDTLPIWLLMLGIYWDHLVRFRKRARRLVELLLEKLRQAITTEPKELFRPLVDRVSVLVRRLCREQTSSVVLPRSWDRYHDVVSSCLHLDDPTENSILQSLHTRNARVRQAKDWRKAAQRSPQQQVIQLLDAARSAHDVSALSDACLGTMADREALVSELLEWTGTPFREGLVRVYIAVRLLRKWKRLGIDVDAHIFSFLAKSRDKFRLQMANIYHVVVELVRSQTFSVGRYLQWLVARGAIERYRQQELQRASSEGEYGSTSQSSTTTSLPGDIELLSQLPVSRLPQHLRNLRDTLLARAGLSLSEEDVTRTVKADIKQRLPAVFRTELSEDDAMVCHTDPSHLSWSVKSEIGQWVRRGVSEHYKDGSQFVADKSSASSVEISSLTPDEFFTVRSTLENFGDLSMLADVLSDAANSDDVLVLASAVDTANRHFDCFSVIGALNDLFKSFFEAFARVKQSGLPLYDLVFSLVELGHRLPNEVNAVVVLRQELARADLSDHMAETLNDTNPSFNDDLEQFLSSGNSMDENTLAMVFQKLSQQLELCDDQGKFSTSTICRYLVQLRSFNPKHFDLLLIRWIEGLLKSSTRPKLSNILAPLVGVGCVTLPAFSAMMKKLMLSESTRSAIPHLAELQLDLLELFVPDANGPSADLLSYRFRMAQEEFLSKHSDEALGIIQNTAACLATQAAQPGLDSVRASLENYTIPLLRHLLVRHPESITQRCVHTLLEHYPATVDVVRRTLNLLLGFNAQPGENNTLAEAEEAINMTNNFSLPFCQLKLQLLFNMEGGEEVKSGIVDIMFKAAVADVRAGQTYWLDLVALMSQDAVQQIRQRAEKGFFSVAQSDSSLEGDSPVERSNLRETARVYLTIIDGLAYSIPEVGVPSVTPLLVEKMNSLLQRLVQTQINIRSLSENRNGTMADQVARSLSVCEENFIFWFTAMLRMITIHRAAFDAPAPSASQRPNSLLDQSRLLITIFCIALSRSPLGMASHPHAGICPSPSTTSAQQSRAGNSLQTYALDVAASLIDTLPDDARQQCARFLRERCPPFLHVHNEPRLMYLLGPVPDFSTTSSSQPVSAPSPATSGPTSSLTPTATPASGSSSIPPSTNAGSMVPTGPVEDPNSLANRLRIQHRGRVVGPYPLRPWEMLEEAAPVAGVNDTAVDLGYFGARRVRD
Length1722
PositionKinase
OrganismRasamsonia emersonii CBS 393.64
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Rasamsonia.
Aromaticity0.07
Grand average of hydropathy-0.264
Instability index50.60
Isoelectric point8.33
Molecular weight190192.63
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03976
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     641.48|     183|     198|     663|     860|       1
---------------------------------------------------------------------------
  545-  656 (149.46/84.92)	...............................SSLENATLDTL................P..........................IWLL....MLGIYWD.HLVRFRKRARRLVELLLEKLRQAITtepkELFRPL...VDR.VSVLV.............RRLCRE.......QTSSVV.LP.RS.....WDRYHDVVSSCL..HLDD..pTENSILQ....SLHTRN
  663-  860 (278.33/202.81)	K.DWRkaaQRSPQQQVIQL.LDAARSAH.DVSALSDACLGTMadrEALVSELLEWTgtPfREGLVRVY...............IAVRLLRKWKRLGIDVDAHIFSFLAKSRDKFRLQMANIYHVVV....ELVRSQTFSVGRYLQWLVARGAIEryrqqELQRASSEGeYGSTSQSSTTTSLP.GD.....IELLSQLPVSRLPQHLRN...LRDTLLARAGLSLSEED
  866- 1049 (213.68/125.96)	KaDIK...QRLPAVFRTELsEDDAMVCHtDPSHLS..........WSVKSEIGQWV....RRGVSEHYkdgsqfvadkssassVEISSLTPDEFFTVRSTLENFGDLSMLADVLS.DAANSDDVLV......LASAVDTANRHFDCFSVIGALN.....DLFKSFFEA.FARVKQS....GLPlYDlvfslVELGH.....RLPNEVNAvvvLRQE.LARADLS.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.58|      33|      60|     142|     174|       2
---------------------------------------------------------------------------
  142-  169 (39.62/19.95)	..................................SGSRAGD.STGSVALSSAALPDK...........PSMAAA
  170-  231 (34.06/15.90)	PPNGHqtvidltsndsttpesehpskrprldtnvSGP.AGDgKTRSAELRSASASGT...........PRPATV
  232-  277 (31.27/13.87)	PGRGR...........pacsfqelvsetygagfsSGNLTPG.SQTTKPASPPPFPIR...........P.....
  282-  315 (20.63/ 6.13)	..................................SSQQSGS.GT...AVANESTPERevqttpyrlevPSI..A
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.11|      21|     199|    1358|    1378|       4
---------------------------------------------------------------------------
 1358- 1378 (40.88/24.94)	RAG...QTYWLD....LVALMSQDAVQQ
 1557- 1584 (29.23/15.84)	RAGnslQTYALDvaasLIDTLPDDARQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.26|      54|    1413|      76|     133|      10
---------------------------------------------------------------------------
   41-  104 (82.68/60.29)	Q....KPEGAPTARRRVFSSP.HIPAAVIYRQH..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................waphsnpITSAAFNSPFTrfrNAGTLPNPFRDVQSL
  105-  133 (33.65/19.24)	Q....CPDVQRSERRHASDVPaMIPHSSSGVQP..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1495- 1520 (30.37/13.06)	.................................wvnqsripsgsragdstgsvalssaalpdkpsmaaappnghqtvidltsndsttpesehpskrprldtnvsgpagdgktrsaelrsasasgtprpatvpgrgrpacsfqelvsetygagfssgnltpgsqttkpaspppfpirpwkyassqqsgsgtavanestperevqttpyrlevpsiapilkgdkfadfspwtgnhpedllseqttkqghydrtqvsqnesntarpslyaqlkhrsglqvlssvfaaalekrqahnkvasastfkppprvtltdnkreawlrdlanpsvplrrlsrtiphgirgkvlldqclskwipigravwlakcvganeirafkrkgtsgslalglevkwvrdwttavqqflegvvsscgkedwkmkmtysvrltarlffenlldqdcyldwylsslenatldtlpiwllmlgiywdhlvrfrkrarrlvellleklrqaittepkelfrplvdrvsvlvrrlcreqtssvvlprswdryhdvvssclhlddptensilqslhtrnarvrqakdwrkaaqrspqqqviqlldaarsahdvsalsdaclgtmadrealvsellewtgtpfreglvrvyiavrllrkwkrlgidvdahifsflaksrdkfrlqmaniyhvvvelvrsqtfsvgrylqwlvargaieryrqqelqrassegeygstsqsstttslpgdiellsqlpvsrlpqhlrnlrdtllaraglslseedvtrtvkadikqrlpavfrtelseddamvchtdpshlswsvkseigqwvrrgvsehykdgsqfvadkssassveissltpdefftvrstlenfgdlsmladvlsdaansddvlvlasavdtanrhfdcfsvigalndlfksffeafarvkqsglplydlvfslvelghrlpnevnavvvlrqelaradlsdhmaetlndtnpsfnddleqflssgnsmdentlamvfqklsqqlelcddqgkfststicrylvqlrsfnpkhfdlllirwiegllksstrpklsnilaplvgvgcvtlpafsammkklmlsestrsaiphlaelqldllelfvpdangpsadllsyrfrmaqeeflskhsdealgiiqntaaclatqaaqpgldsvraslenytipllrhllvrhpesitqrcvhtllehypatvdvvrrtlnlllgfnaqpgenntlaeaeeainmtnnfslpfcqlklqllfnmeggeevksgivdimfkaavadvragqtywldlvalmsqdavqqirqraekgffsvaqsdsslegdspversnlretarvyltiidglaysipevgvpsvtpllvekmnsllqrlvqtqinirslsenrngtmadqvarslsvceenfifwftamlrmitIHRAAFDAPAP...SASQRPNSLLDQSRL
 1521- 1548 (31.56/14.23)	LitifCIALSRSPLGMASH.....PH.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AGICPSP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.51|      13|      15|     431|     445|      11
---------------------------------------------------------------------------
  431-  445 (16.20/16.57)	LSRTIPHGiRGkVLL
  449-  461 (27.31/15.81)	LSKWIPIG.RA.VWL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03976 with Med12 domain of Kingdom Fungi
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