<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03972

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKTCTTNIHVVEDLAETALLLYRLRDERAGSTQKLKEARNAVSHLRREKVLCAIVEQDIYIFGDVSPEHTLELEDRYELVEEGTVGSQDETTSVNTKDIFLDAVEHAIAFSLAADSAITYVASWTWLYHDAEAENGSDADSGSIIKMHAEYTPTAALLLVPEILPASWLPIGHADEQVESHIILAPRGIPARRIAEARRKVWSDNAWKVNVSEALELDAIRTDNDTVWISVELQDSAGLCCLWPAELCLAPATATNLEFCAMTRRSDWRRWLVGLEEEDAFRNPLAVAEEWFKGAGEREQAVQNAVKASTSDPHSSQTHVSTAANDEEAMTSPPFMQRALDQQTAVSGIYPTPPDGMAQAPQTAHMNLGATPSVAHTDNTMSGVEMTSNTNDHAQSNGSDPDQSLDREDFELNQEDLFGDNSGGIEFGEDAVDDADFNFFDEPDDEPEQGTVASTEMDDESTHEHELEPVIAQDTVNELQPTSDDISTAAAVDSAVSEHLTLPTSDDTAGENVLTAGSDESRFATHTSEPEKALSPFGIRERLLPPPVPASLANTDSNDFARFRRHSTFAPIVFKNSFNLGPKYADTGLVDDEAQRPMIKSKIPNINLPPVKKKSRLLRQEVNMEPRMMDPNSESEEDSYESASSDSDDELPPKLPWDTRKRKRPSDEDRLQPLASSMERMLSDDDPGDDSETTESQHNADTMLEKCLTRASDGGMAVSLRNSSDNYSDCGPKNASDEESGDSSMRKVEELYSLRKEDLIYVAQIVHEQAMSMTRSSVAEQDLFSNGGSDPEKAQCGRISIAKAVESVFPDAAICDLVQLAATRDQAPRPTVPVKTPQGQPRMPQRSDSQIVLGPDYFPLPSPYVRIQRGADNWEMMSTCLSFWETLGLGPTNGPKNVRAFCVFPFNEDLQHLVAQFIGELGTSYENCKLGSYVHLRNVSDASLDSFEDGMAPVEVNEEEESVEGLLKAYATTCAELGKVLSTIGHEESDRTIVVYMLNPFSGRQALQHLCACFWVLFKAYRDNVPKALRNQCGSDIVLQVLPIKLVASFDELVVPEAKEIALLAREVYDRCPPSVSHNSETLSALPILAAPSVELANAAPKRIGFQLAAEPPSDLLHEGSILHLAYACSQDGHWLTVAWIDNTGQHQSTASFCLRGKTFSEVAEGVWDRTREILAARQVTWRVFIVTPDAMDTSLSHCWRSITSRRRPYPLCVTLLSVQLDPILHLSPPAVPLDTQFTWPTADGGFLTPASTPQAGNLTSSPNPGGDSTAPPTPAPSETMTAASIAENDPDAHLTDLTDETWGVLLSPKLAPFTSPFPGQANGALFRRGDPSPGEALPSLGVSVHWTIQVKPSGGVDDGSVKQAELTCREVLKMYRGLSVLTKARGLDGGRRGTEWVAPVHVAMVVRGVEGLEGFLEKDEKGES
Length1428
PositionKinase
OrganismZymoseptoria brevis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.06
Grand average of hydropathy-0.409
Instability index47.50
Isoelectric point4.58
Molecular weight156286.13
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03972
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     260.08|      53|      60|    1232|    1284|       1
---------------------------------------------------------------------------
  655-  706 (87.81/38.16)	PPKLPWD.TRKRKRPSDEDRLQPLASSM.ERMLSDDDPGDDSETTESQHNADTM
 1232- 1284 (97.10/42.94)	PPAVPLD.TQFTWPTADGGFLTPASTPQAGNLTSSPNPGGDSTAPPTPAPSETM
 1294- 1341 (75.17/31.67)	PDAHLTDlTDETWGVLLSPKLAPFTSPFPGQANGALFRRGD......PSPGEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.92|      19|      19|     330|     348|       2
---------------------------------------------------------------------------
  310-  327 (23.67/11.07)	.KASTSDPHSSQTHVSTAA
  330-  348 (33.77/19.32)	EEAMTSPPFMQRALDQQTA
  351-  367 (31.47/17.44)	GIYPTPPDGMAQA..PQTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.18|      18|      21|     469|     488|       3
---------------------------------------------------------------------------
  471-  488 (32.74/22.42)	EPVIAQDT.VNE..LQPTSDD
  490-  510 (21.44/ 6.17)	STAAAVDSaVSEhlTLPTSDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     254.89|      82|     162|     963|    1049|       4
---------------------------------------------------------------------------
  963- 1049 (130.22/115.42)	EESVEGLlkAYAttCAELGKVLST..IGHEESDRTIVVYML..NPFS....G..RQALQHLCA..CFWVLFKAYRDNVPKALrNQCGSDIVLQVLPIKL
 1122- 1215 (124.67/92.70)	EGSILHL..AYA..CSQDGHWLTVawIDNTGQHQSTASFCLrgKTFSevaeGvwDRTREILAArqVTWRVFIVTPDAMDTSL.SHCWRSITSRRRPYPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.57|      20|      22|     162|     183|       5
---------------------------------------------------------------------------
  162-  183 (30.55/26.14)	LVPEILPASwlPIGHADEQVES
  187-  206 (36.02/22.25)	LAPRGIPAR..RIAEARRKVWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.01|      10|      23|     722|     731|       6
---------------------------------------------------------------------------
  722-  731 (17.64/12.51)	SLRNSSDNYS
  747-  756 (17.37/12.20)	SMRKVEELYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      13|      23|     274|     286|      10
---------------------------------------------------------------------------
  274-  286 (24.42/16.98)	WLVGL.EEEDAFRN
  294-  307 (20.47/12.92)	WFKGAgEREQAVQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.86|      22|      25|     389|     413|      12
---------------------------------------------------------------------------
  392-  413 (40.15/26.96)	NTND..HAQSNGSD.PDQSLDREDF
  416-  440 (29.70/10.88)	NQEDlfGDNSGGIEfGEDAVDDADF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.76|      14|      24|     207|     220|      15
---------------------------------------------------------------------------
  207-  220 (23.31/14.62)	DNAW.KVNVSEALEL
  228-  242 (19.44/10.85)	DTVWiSVELQDSAGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03972 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEREQAVQNAVKASTSDPHSSQTHVSTAANDEEAMTSPPFMQRALDQQTAVSGIYPTPPDGMAQAPQTAHMNLGATPSVAHTDNTMSGVEMTSNTNDHAQSNGSDPDQSLDREDFELNQEDLFGDNSGGIEFGEDAVDDADFNFFDEPDDEPEQGTVASTEMDDESTHEHELEPVIAQDTVNELQPTSDDISTAAAVDSAVSEHLTLPTSDDTAGENVLTAGSDESRFATHTSEPEKALSPFGIRERLLPPPVPASLANTDSNDF
2) TPASTPQAGNLTSSPNPGGDSTAPPTPAPSETMTAASIAENDPDAHL
3) YADTGLVDDEAQRPMIKSKIPNINLPPVKKKSRLLRQEVNMEPRMMDPNSESEEDSYESASSDSDDELPPKLPWDTRKRKRPSDEDRLQPLASSMERMLSDDDPGDDSETTESQHNADTMLEKCLTRASDGGMAVSLRNSSDNYSDCGPKNASDEESGDSSMRKVE
299
1252
587
563
1298
752










Molecular Recognition Features






MoRF SequenceStartStop




1) FGIRERL
2) IEFGEDAVDDADFNFFDEPD
3) KKKSR
4) PNINLP
5) REDFELNQEDLFGD
540
428
615
607
410
546
447
619
612
423