<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03968

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMPFMETPTSVENTCKWKTFLRNARVRRMKAQLLTVSLRELQRRYPLDAKAIAAQLVSFRARPSGMNDPLFYSYATLFLREKLITSADLLLALFDSSVARSGRSGNPISTRTFGQPCYEERMFTIMTQIHLSTELPSSAIDVHSLVHAVVKWLHHVCEYEMGRQLEGAGIDTMHPCSLGAYEALGSLAISILGNQGIRNVAKQSWWKAGRAQVVEEMQNYDANILQWMQSQVAGRLRALTGMPPYIKTDGKGRPVLTDDQILEAIPEVPTMNSRAGLFLWLNAALTARPLTDDMTVLGYLHARYPGNVQSLVVDLLVASFDNLTNAMLRKEIRQNVKVIRSFICNKLPTLIAMLCGSIGEQITPEACIQMALIPGGLISMTPLPPISNGATDIEESLKGTRLEFLQACALHGLVAESTIAAILRGPIALPRVTKYSKETLVAQCANNPSRLAPLIDDLNGMQGNAGAISGCVVETISNLCMSKDTMSLKTVCNELIKRIAYMDVVMQYTQPQMLLLPLCNLLNEWMHDQDQTEFTPSYEEFASILLLTLATMHRYEIRWPDIGVLEESFIARLLDDMSGSKPPSELPDEQGSQLAKWIEGLFAVDDSGETSGIGDDVMRQCSPQNFYLLVPTLFEQSVLACRSNALAINTFKGGLELLLEPFLLPSLIMGLGWLVEHSWDDHNDVDLLLQVLEKLLKPSSTSQETQAMHRTILSMVATPWHDSLQELQRRQPDKKKFAELSALLTPHLSNQRTLSCRRSELNDWIQNEGALKARVQQSLRELIRWASTSTNPPDPPPRYAHRLFVVACQALSPEKLLSVILGEITATDFSTIPTALDVCASMICAPTALSAATHQPGSAIALSPVTTLRNHIRHLVSEPQDLLTRPQRNAEALVQLSRRIESQLSIAQMPALTIPLQMQDQAADQMMQDLGLDIAAAGDGNSNAIGAGASGSIDLGPEFAGLSGISQSQAQELVELANADGASGSAAGGMDLGDQGVFGGLLDLNSGTQGDGSGGQESSQGGMNNDDDIFAGLDMIGDFEMD
Length1041
PositionTail
OrganismZymoseptoria brevis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.06
Grand average of hydropathy-0.058
Instability index49.57
Isoelectric point5.10
Molecular weight113806.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03968
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.78|      25|      32|     979|    1003|       1
---------------------------------------------------------------------------
  938-  964 (34.90/18.70)	DGNSnaigA..GASGSIDLGPE..FAGLSGI
  979- 1003 (47.75/28.37)	DGAS....G..SAAGGMDLGDQGVFGGLLDL
 1010- 1034 (39.14/21.89)	DGSG....GqeSSQGGMN.NDDDIFAG.LDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      18|      32|     240|     258|       2
---------------------------------------------------------------------------
  240-  258 (31.18/26.02)	GMPPYIKTDGKGRPvLTDD
  275-  292 (32.89/22.15)	GLFLWLNAALTARP.LTDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     290.04|      76|     223|     317|     392|       3
---------------------------------------------------------------------------
  317-  392 (133.88/96.26)	ASFDN......LTNA.MLRKEIR.QNVKVIR.SFICNKLPTLIAMLCGSIGEQITP.EACIQMALIPGGLISMTPLPPISNGATDI
  490-  533 (59.78/38.16)	..................................VCNELIKRIAYM..DVVMQYTQ.P...QMLLLP..LCNLLNEWMHDQDQTEF
  535-  616 (96.38/66.85)	PSYEEfasillLTLAtMHRYEIRwPDIGVLEeSFI.ARL..LDDM.SGSKPPSELPdEQGSQLAKWIEGLFAVDDSGETSGIGDDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     280.49|      95|     683|      36|     147|       4
---------------------------------------------------------------------------
   36-  147 (137.31/129.11)	SLRELQRRYPlDAKAIA...AQLV.......SFRARPSGMNDPLFYSYAtlfLREKLITSADLLlalfdssVARSGRSGNPIStrtfGQPCYEERMFTIMTQIhLSTE.................LPsSAIDV.HSLVHA
  722-  844 (143.18/90.46)	SLQELQRRQP.DKKKFAelsALLTphlsnqrTLSCRRSELNDWIQNEGA...LKARVQQSLREL.......IRWASTSTNPPD....PPPRYAHRLFVVACQA.LSPEkllsvilgeitatdfstIP.TALDVcASMICA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03968 with Med5 domain of Kingdom Fungi
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