<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03960

Description RNA polymerase II mediator complex component Srb8 like protein
SequenceMDYRPPPGLSRPAPPQRAASGSYAVQQGLRRPPLPSRLQNVRSVSQPGGMVDVPGDGSRVDVRNTAAFLSNSNATTNLPGAINPTAQDDSERPLKRAKIGGHGFRGTGEGGEVATDRAHRTVPGLALPILPAPTTATRRNAKQITTTRPGVDRAARKANGLEPPSIATRVPQPKNVADFSPWHGQHPEDTMSEIVVKQGYFDKAAGPNSTETNSARTTIWPNLSQKNMMGLQTLSYLFTSVMEKRQLLGKCTAPSTFKPPPRVTVTDTKREAWLRDLANPDVPLRKQSRTIPHGIRGKSLMEQCLSKDIPMPRAVWLAKCVGANELRAFRRKGVSGAAAASGESKWVMEWTAHVEQFLEGVIASCGQPDWQAKMDYAVKLATSFYTERLLDRDHYLDWIVSSFAEASMETLPTWLIMVQLYWRDILAFGRRGRQLAEAALENLHQISMRKTSIHDALKHRLKKLIAIMAVTNRGCLVVPRTWEKYKYLLVPRMTGGNTTSHALNVARRNTRLTAPLLQTPQNIQCALLRLYAVLDTTGLKLDLAELAADCIAIVPEVPRLVSAILDWSASMYRTGTDRTYLAARVVAHLRRAHDTDAAIMQLLRSGMSIALDIDNVHRVIAELVRSEAFSTGRYLQWLMTSGALSVNNGVSPATSLLNALPTSTLQPHLLNTRNMLLRRLGLLKNESRQIDEILQRSDPGRWAADVEQQEVATVVDALSVSAKLELALRISSQAVASGKLGHMPLEHFCMVREIIERCDDARALADLAQSAMHCDDTILLATVCDTLNMHAKSLAAIGRLNGSLVQICERYSTVRSQQPLDRAFILALRALSQRFPERAHMVKLLDQDMTICEQQNSMAVCSPASDSIVNMQASTLASDEDIDAVFASGNNMDEQLMQRVFARVVQRLNKTMQPDATAPSKICGWLSQLRAVVVDPVSFDQMAVSHVQACLENAGEDMAPCKIVVALVAGGCMNFDTLVNTAIATKKAASACLAIRLLTSRTAACEGLHSTEAYRYHIQQELYCFEKAEEVMTALVSAMEDSNFPAEDPGVIDLVLRYSVNHHDAAYRALASHSRSTALLANCSRITTKLLSLGNNPAAIDSRLDAKSIIGQATPLSIVQCSAALRLYSIVHPDEAEHVQKAVLEAVVAGSEVWPQLLESAGNETVRGIYGWAKEQVLNNALPLSTSSEHLDEASTFRNVDILDVAIHAAKEQDVSAVIATVTDKLRALEIQISSSDSVSSLKSLLGSLQTLLHLAILYGSPTSESSGSTDRNDSQALIGLLTSLCALLIHPKLQTQTSLLEYIYDVASALSDSLQDTVLSNLAKNVPTKDPRLASILGSTANPDAWLAIVSNPSASMTGGAQGARAGLIRSASGVGTSASGLGIQQLSPQQIQQAQFTGRPLPPNQQQGQAMHLQQAQMQAAQRSPGQQFSPTFAKPGGAAGGNARSAVSGNGVGETKIAPFPLRRWEIMSDATPIVGGNDTSLSLGLFGARKV
Length1495
PositionKinase
OrganismZymoseptoria brevis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.05
Grand average of hydropathy-0.146
Instability index43.83
Isoelectric point8.67
Molecular weight161965.27
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03960
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.22|      16|      24|    1226|    1241|       1
---------------------------------------------------------------------------
 1226- 1241 (25.57/16.83)	LRALEIQISSSDSVSS
 1252- 1267 (27.65/18.86)	LLHLAILYGSPTSESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.52|      15|      94|      28|      42|       2
---------------------------------------------------------------------------
    8-   22 (25.80/12.17)	G..LSRPAPPQRAASGS
   28-   42 (27.90/13.79)	G..LRRPPLPSRLQNVR
   48-   63 (18.82/ 6.78)	GgmVDVPGDGSRV.DVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.63|      28|      97|     311|     340|       3
---------------------------------------------------------------------------
  270-  302 (36.19/18.31)	REAWLRDLANPDvPLRKQSRtipHGIRGKSlME
  313-  340 (47.44/36.08)	RAVWLAKCVGAN.ELRAFRR...KGVSGAA.AA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.19|      23|      74|    1364|    1390|       4
---------------------------------------------------------------------------
 1364- 1390 (34.36/25.38)	GARAGLIRSAsgvgTSASGLGIQQLSP
 1440- 1462 (40.83/20.80)	GAAGGNARSA....VSGNGVGETKIAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.18|      59|      67|    1056|    1117|       5
---------------------------------------------------------------------------
 1056- 1117 (89.16/67.36)	LR.YSVNHHDAAYRalASHSRSTALLANcSRITTKLL.SLGNNPAAIDSRLDAKSIIGQATPLS
 1125- 1185 (93.02/59.05)	LRlYSIVHPDEAEH..VQKAVLEAVVAG.SEVWPQLLeSAGNETVRGIYGWAKEQVLNNALPLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.79|      13|      74|     946|     958|       6
---------------------------------------------------------------------------
  946-  958 (25.64/19.21)	HVQA...CLENAGEDM
 1017- 1032 (18.15/10.99)	HIQQelyCFEKAEEVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.51|      39|      74|     600|     646|       7
---------------------------------------------------------------------------
  600-  646 (60.01/55.13)	MQLLRSGMsialdIDNVHRVIAE.LVRSEAfstGRYL.....QWLMT.SGALSV
  675-  720 (53.50/32.01)	MLLRRLGL.....LKNESRQIDEiLQRSDP...GRWAadveqQEVATvVDALSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.94|      17|      19|    1392|    1408|       8
---------------------------------------------------------------------------
 1392- 1408 (32.60/22.20)	QIQQAQFTGRPLPPNQQ
 1414- 1430 (31.34/20.99)	HLQQAQMQAAQRSPGQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.31|      48|      65|     761|     824|       9
---------------------------------------------------------------------------
  761-  824 (58.42/89.83)	ARALADLAQSaMhcddtillaTVCDTLNmhakSLAAIGRLNGSLVQIceRYSTVRSQQPLDRAF
  839-  886 (83.89/64.58)	AHMVKLLDQD.M.........TICEQQN....SMAVCSPASDSIVNM..QASTLASDEDIDAVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      22|      92|     480|     503|      11
---------------------------------------------------------------------------
  480-  503 (34.17/26.18)	RTWEKYKYlLVPrMTGGNTTSHAL
 1466- 1487 (41.21/22.53)	RRWEIMSD.ATP.IVGGNDTSLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.75|      18|      19|     511|     528|      17
---------------------------------------------------------------------------
  511-  528 (31.82/16.82)	RLTAPLLQTPQNIQCALL
  529-  546 (28.93/14.69)	RLYAVLDTTGLKLDLAEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.13|      14|      19|     179|     192|      18
---------------------------------------------------------------------------
  179-  192 (27.88/12.87)	FSPWHGQHPEDTMS
  201-  214 (21.24/ 8.37)	FDKAAGPNSTETNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03960 with Med12 domain of Kingdom Fungi
Unable to open file!