<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03958

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGRLVMEQQKDAGLQDLKKDRSNAQGEDVLHTQDAFNGQNSASQKAAAHGQVNTSEATGLPTPPELDQSWRDGPDNKPMGVLIERLAQQCFTDLGTTLKTMAEVPESTQANGVVPHAVDTSVASLTKKRTLMDFAHNQRDRFIKTLVLSDWARNEQDMARLVDIKVWQERQLGAQVQAISSIGNTKHNMQGAKIPNPNLDGALELLATGTSRMPDLGYLPPKKLSAKQLLRTLQDMNVALATRLNMHEELPYYFNDLSIANGRATFRVADEFEVDLSVGDEDPSTPFWFIDMRFLFSPTPDITDDVSRMELEKRVNIALASESKLQGCYDLLHNFVLTHKINVLRDQASQLLREKWFECLFVEMKKRVLIIQYWSDLAGPKSWFEIGVSTGKQNRKGSKPANAQLSVRWFRRGQEVLDDPPYIDWKTLNVEQVLGTVIAKHTSCDLRNTQNGLVKLAGPNSKLDITLDACADTPEDCSLALGLPGMRTPYIVRKEVVTGKWAISPPTMLAARAERSMNADLKADPAVQLAQMLCGTNQERIGKAADLAGWIAVASRTLAPQNNLKALFGADTVSRSIYNCNRGWSDSWALVATFGLSGDKWWAARMEPKLDARGASTGRIFAEARRISIPSDLVAFPRVARSLLLRIGKLAVAQISLAVVTQDLDSKRIPYKIESTASLTPAERSRGERSSAASAEPAVVLDSASFFDDAKSDPIRKPFKDGAIRLTHHRNIASAPAAAGSRAEVAHCLRLTVRHGVLNHLQEYLLTKPRDADMFMNDRGALALRVRVQFGQPCVSVLQARLKSCKRLDAYLVALARYSFVCTHLSLTRVTFTYPSNPDLSATVRFSINPNVPPSADLKLHPVDFNPHQRVRVIALRTFNLAPLDPKSFTALLYTLRTSISLNTAYSTISALPPLGSLHIHPHHLLAYLWTYSAPLPGAGAQFKIQWRPNVGEKKKGVWHIMTQLSKPNKGSGELSEEVRTGIAEVCLKKGSGRIGNGTSIVVEDELVGEVIRELDRVCREGGEAVAGKKEEETKDVKVETTGRPSVAAQRTGLSTSVKTQGGQQKTAQLKSGGHAGLQQANGSGNGNGHRGSVTNGNGNANGNGRLKQEIIELD
Length1116
PositionTail
OrganismZymoseptoria brevis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.06
Grand average of hydropathy-0.339
Instability index31.72
Isoelectric point9.18
Molecular weight122473.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03958
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.04|      24|      25|     336|     359|       1
---------------------------------------------------------------------------
  336-  359 (42.13/23.90)	FVLTHKINVLRDQASQLLREK.WFE
  362-  386 (40.92/23.03)	FVEMKKRVLIIQYWSDLAGPKsWFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.51|      30|      30|     818|     847|       2
---------------------------------------------------------------------------
  758-  789 (25.19/12.03)	....VLNHLQ..EYLLTKPRDADmfmndrgaLALRVRV
  790-  815 (34.82/19.41)	QFGQPCVSVLQARLKSCKRLDAY........LVA....
  818-  847 (51.51/32.20)	RYSFVCTHLSLTRVTFTYPSNPD........LSATVRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.80|      13|      32|     207|     219|       3
---------------------------------------------------------------------------
  207-  219 (23.91/16.98)	LATGTSRMPDLGY
  241-  253 (23.89/16.96)	LATRLNMHEELPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.01|      15|      18|     959|     976|       5
---------------------------------------------------------------------------
  959-  976 (22.52/18.30)	VWhimTQLSKP..NKGSGEL
  980-  996 (18.49/ 6.93)	VR...TGIAEVclKKGSGRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.08|      15|      19|    1072|    1090|       6
---------------------------------------------------------------------------
 1072- 1090 (24.18/16.03)	KSGGHAGlqqaNGSGNGNG
 1092- 1106 (28.90/11.52)	RGSVTNG....NGNANGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.52|      17|      19|    1023|    1041|       7
---------------------------------------------------------------------------
 1023- 1039 (26.99/16.40)	GGEAVAGKKEEETKDVK
 1044- 1060 (27.52/10.80)	GRPSVAAQRTGLSTSVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     130.53|      20|      24|     509|     528|       8
---------------------------------------------------------------------------
  509-  528 (33.85/17.36)	ML.AARAER.SMNADLKADPAV
  533-  554 (20.64/ 7.88)	MLcGTNQERiGKAADLAGWIAV
  558-  574 (23.64/10.03)	TL.A..PQN.NLKALFGAD.TV
  602-  620 (29.85/14.49)	WW.AARMEP.KLDAR.GASTGR
  621-  640 (22.55/ 9.25)	IF..AEARRiSIPSDLVAFPRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.97|      18|     201|     183|     200|      10
---------------------------------------------------------------------------
  183-  200 (34.54/21.83)	IG..NTKHNMQGAKIPNPNL
  387-  406 (27.44/15.79)	IGvsTGKQNRKGSKPANAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.11|      17|      19|     861|     879|      11
---------------------------------------------------------------------------
  861-  879 (26.39/25.90)	LHPVDfnPHQRVRVI.ALRT
  882-  899 (24.72/15.63)	LAPLD..PKSFTALLyTLRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.58|      12|      21|     906|     917|      12
---------------------------------------------------------------------------
  906-  917 (22.57/12.27)	AYSTISALPPLG
  942-  953 (22.01/11.79)	AQFKIQWRPNVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03958 with Med14 domain of Kingdom Fungi
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