<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03957

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSTSDGERSPKRQRLESYSPASPQPTVDTRHFVPPQTPPPSVRMSPSWTAQTLPAQPTGSGTSTTFPTPPSTAGYLGHMAGRGAGSEGGGESGHQTPAGEDEGYARRDHDGDAEMTDRPESGNDGVSSVDAEHRRTDHEREGAGGDITAPVPGAGVLYKLSTAPIAISRPHPSQDLIQLYDLKRIQAAVARRDPVTGEKINVLRKSYANKVKKLGLEGLNKAQSNLHELEGLLDPMWNNDAGNGATLWENHCEPMRMDKADVQEDLLNKLDDALRMKPGRLPAKEHEQWKSMLGLDEAIAPAVATKGGNTPNAAKLSGTSAFAKTSPGTGARNSAPASPRSLSRPDRSNKRRRYDDTSYEGYQQGFEDDGYSTGGVDDTGRRGSGVKRQKRKDFASSANSPAFTNGSGSNGMVGVRSS
Length418
PositionHead
OrganismZymoseptoria brevis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.05
Grand average of hydropathy-0.927
Instability index56.13
Isoelectric point7.18
Molecular weight44613.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03957
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.94|      18|      19|     143|     160|       1
---------------------------------------------------------------------------
  143-  160 (32.33/19.59)	AGGDITAPVPGAGV..LYKL
  163-  182 (28.61/16.52)	APIAISRPHPSQDLiqLYDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.96|      16|      20|      80|      99|       2
---------------------------------------------------------------------------
   80-   95 (27.81/15.97)	AGRGAGSEGGGESGHQ
  109-  124 (28.15/ 7.31)	HDGDAEMTDRPESGND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.17|      17|      18|     219|     236|       3
---------------------------------------------------------------------------
  220-  236 (30.00/23.04)	NKAQSNLHEL.EGLLDPM
  238-  255 (28.17/15.61)	NNDAGNGATLwENHCEPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.58|      19|      19|     302|     320|       4
---------------------------------------------------------------------------
  302-  320 (31.45/15.85)	AVATKGGNTPNAAKLSGTS
  323-  341 (33.13/17.09)	AKTSPGTGARNSAPASPRS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03957 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APAVATKGGNTPNAAKLSGTSAFAKTSPGTGARNSAPASPRSLSRPDRSNKRRRYDDTSYEGYQQGFEDDGYSTGGVDDTGRRGSGVKRQKRKDFASSANSPAFTNGSGSNGMVGVRSS
2) LLNKLDDALRMKPGRLPAKEHEQWKSMLGLDEA
3) MSTSDGERSPKRQRLESYSPASPQPTVDTRHFVPPQTPPPSVRMSPSWTAQTLPAQPTGSGTSTTFPTPPSTAGYLGHMAGRGAGSEGGGESGHQTPAGEDEGYARRDHDGDAEMTDRPESGNDGVSSVDAEHRRTDHEREGAGGDITAPVPGA
300
266
1
418
298
154










Molecular Recognition Features






MoRF SequenceStartStop




1) LIQLYDLKRIQ
2) TVDTRHFV
3) VKRQKRKDFASSA
4) YLGHMAGR
176
26
386
75
186
33
398
82