<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03953

Description Transcription mediator complex subunit Med12
SequenceMIPHSSAGVQSWGHPLRAVNSGSGHVDASQAVGPSDSQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDVSPAPGSGGELRSTPGTGGSKPPSLSWRNRPVWSFQAMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYVPESLGSNPTTSRASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWTGNHSEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVSRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTASVQQFLEGVLGACGSAQWKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNTVPVWLLMLGIYWDNIMRYRKRGRRLAELLLVKLRQVTQPEKGGPLQPLVDRLSLYVRRLVLEHTSSVVLPGSWENHKELISSCLNLKDNVHKTIYQNLSERNSRLQLPKNHQDTAERSPQQRVIQLFDSIRSAHDISSASTACLKTIEDKAMLISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSYILSFLADVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTPQPVSSDLCLLKQLPANRLPEHVRNLRNTLLYRAGIPVMEEDSAIEELKISIAQRLPNIFGAELDSAMPTESSQPNPTWAVKSEIGQWIRHGVAGHCRDSPRKFPGVSVAVDPGASALTPDEFYSVREILETFGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVGLLRQDLTRLENKSALAAPSPLSDSIPLALSDVDPSFQEKLNQLLSSGGGMDESTMDTVFYSLMHILESSGSPAKLSANETARYLAYLRPFQPKHFDTMLIRWICGLLKSSTPSISRILPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLAGLRVDLLQLLVPLVSGKSKYADLVTYRFHVAQQEFFMKHPQETLDIICDAVALVNSETGSNPGQPDIAGCATELLDILLTQNPEVTVQYCLQGFIGKHSTSTTVLERALDNLLGFDSLAGPPTMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRNVGNGIVDVMFKAAVEDTRSKGSNWVGFIRERAERALFSIPLFEEHLEAHGHPGTAKSLETAKLYLTIIEKLAYSVPEAGVQSVAPILVEKMDLLLHRLVIMQTNFNNVTMNRHGAATTQILQSRSNFERSLAFWFSAFLRMIVIHRSAFTMPSPAPRPNGLQEQSRLLISILCISLARLPDSVIRLFPAADYFPHPIPSEGYRPCPGILLQTHALDVAASLIDTFPDEARQHCARFLKEKCPPFLQYQNDSRFIYLLGPMSDAAALNSLQAASLPSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPSVTSASLSEGINCVASHLRLQYRGRVMGPYPVRPWELLEDAAPIVGVNDTAVNLKFFDARRVRA
Length1575
PositionKinase
OrganismAspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.136
Instability index50.10
Isoelectric point8.59
Molecular weight173225.88
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03953
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.92|      79|     313|     337|     448|       1
---------------------------------------------------------------------------
  337-  434 (113.59/105.54)	VSRAV.WL.AKCVGANEirafKrkGTSGTLAL..GLEAKWVRDWTASVQQFL...EGV.LGACGSAQWKMKmtyaVSLTARL..FFERLLDhdqylgwflSSLEAAPV
  662-  750 (105.34/64.27)	VGRYLqWLmAKGVTNTP....Q..PVSSDLCLlkQLPANRLPEHVRNLRNTLlyrAGIpVMEEDSAIEELK....ISIAQRLpnIFGAELD.........SAMPTESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.76|      13|     313|     119|     136|       2
---------------------------------------------------------------------------
  119-  134 (21.56/21.20)	PV..WSFqamLSEVPGSN
  157-  171 (22.21/ 6.41)	PVlpWKY...VPESLGSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.49|      28|      36|      23|      55|       9
---------------------------------------------------------------------------
   23-   53 (39.84/20.85)	SGHvDAsQAVGPSDSQFeKLPTP.VPQPQPRQ
   62-   90 (42.65/14.77)	SGG.DA.QELEPPPKRL.RLDLPaAPSARDVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     275.10|      90|    1089|     172|     261|      10
---------------------------------------------------------------------------
  172-  261 (157.73/102.41)	PTTSRASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWTGNHSEDVLNEQTAKQGHYDRTQVSQNESNTARPSLY...AQLK....HRSGLQMLS
 1007- 1041 (32.10/14.38)	PSISRILPPLIGVGCVTIHAFVFLVKKLLQSEKVA..............................................................
 1287- 1358 (85.27/51.64)	.......................SVAPILV.EKM.DLLLHRLVIMQTNFNNVTMNRHGAATTQILQSRSNFERSLAFwfsAFLRmiviHRSAFTMPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.57|      21|    1336|      91|     111|      13
---------------------------------------------------------------------------
   91-  111 (41.31/17.13)	PAPGSGGELRS.TPGT...GGSKPP
 1480- 1504 (31.26/11.38)	PSPAAGGSTPTpTPSSalpGAPSNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03953 with Med12 domain of Kingdom Fungi
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