<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03951

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWRAFLHQCLMRRIDAAEFKNLSKILSRRCPIAEGTLLDVLLEIRLATGIKWDPLLPLYIDCLCKMGKVQTSTVLTSLLKYSSIHDKPQCPGSETVQSKKALKCYTLMTDIRVIQDAMLSVSTGSTPKSLAEAVGIFSAIIDWIQAVVAWHNNHIDPSQQTGGLMSSPDAVSLFESLGILLTALSGTGKGIEVLSSDFHEALKVKLGQALSAYLPLCMEVSLPLRNRLDSLQKGYNLYGEPPNKSLQSMMDNVNVNALQFEASVMDGPAINSRAGLYIYINAMLMGRPLVDDSMLLNYLTNRYGGHYDVLVEEVITATFDVLSNALYRNESSRTMFLFRSFLVNKLPSFFAAMLAASMVSLPMEMCISHALSRLDPNTFPSFSQMFAMQGSTVLSEVRPEFLFACASHKLIPESSIERLLGENPMQTPPVGYNKDDLMSQINTNQERAEQLVSELESTEGNAGAIVAAITEVMHNLCNQKETMTLKSICNSLSRRPQALDVILLFRSAKQILQPLCTLLDSWHWDEDQGESQPVYDEFGSILLLVLTFKYRYDLRPYDLGITSNDSFVLKLLDCGPSSQKLDDLSEKQNKNLGAWITALFIAEGISEETMSSCSPQEFYLLVTTLFNQSLTACEAGKLEFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWETESDPTVPLKTLQSLVNPSSISGDAREIHKTVLNITARSLDEQLKDIRSRHPNRADIKPILDVLEPCLSFQRTGSCHRSELDSWTTHSPGGLLGSIRSTFQGLVLWSTSPGVSMAPHSYTHRQLVAGIRMLGSARVLTAIVDELKMQTETGNADLALDIAVTMICAPLAESFAIEQSNYHPVDPNKEPLPRCPVLTLRDALSLQHENVPKLSEKDPLRAEVIVRLYRRVNALMTPTSQMPNLDMSNIIQNMQLGVEDHGQMDLEPAGAGHGVGDDDAANLNRMLDNAAAAAAAGLDSGMGQGMDGGLDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1013
PositionTail
OrganismAspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.043
Instability index49.83
Isoelectric point4.95
Molecular weight111525.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03951
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     385.84|     122|     296|     397|     541|       1
---------------------------------------------------------------------------
  407-  534 (195.73/156.12)	LFACASHKL...IPESSIERLLgeNPMQTPPVGYNKDDLMSQINTNQERAEQLVSELESTEgNAGAIVAAITEVMH...NLCNQKETMTLKSICnslSRRPQALDVILLFRSAKQILQ....PLC..TLLDSWHWDEDQG
  635-  768 (190.10/105.83)	LTACEAGKLefdTLKGGFEYLL..EPFLLPSLVVALTWLGNHIWETESDPTVPLKTLQSLV.NPSSISGDAREIHKtvlNITARSLDEQLKDIR...SRHPNRADIKPILDVLEPCLSfqrtGSChrSELDSWTTHSPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.71|      12|      42|     130|     141|       3
---------------------------------------------------------------------------
  130-  141 (21.26/13.13)	STPK..SLAEAVGI
  171-  184 (17.45/ 9.34)	SSPDavSLFESLGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.67|      67|     696|     209|     281|       6
---------------------------------------------------------------------------
  209-  281 (109.45/98.53)	VKLGQALSAYL.PLCMEVSLPLRNRLDSLQKGYNLYGE...PPNKSLQSMMDN..VNVNALqfeasvMDGPAINSRAGL
  900-  972 (101.22/77.13)	VRLYRRVNALMtPTSQMPNLDMSNIIQNMQLGVEDHGQmdlEPAGAGHGVGDDdaANLNRM......LDNAAAAAAAGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.03|      11|     831|      34|      46|       7
---------------------------------------------------------------------------
   34-   46 (16.49/16.17)	RCPIAegTLLDVL
  868-  878 (21.54/12.82)	RCPVL..TLRDAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03951 with Med5 domain of Kingdom Fungi
Unable to open file!